Long-term benefits of targeted micronutrition with the holoBLG lozenge in house dust mite allergic patients

Bergmann, Karl‐Christian; Raab, Jennifer; Krause, Linda; Becker, Sylvia; Kügler, Sebastian; Zuberbier, Torsten; Roth‐Walter, Franziska; Jensen‐Jarolim, Erika; Krämer, Matthias; Graessel, Anke

doi:10.1007/s40629-021-00197-z

Cited by 11 publications

(13 citation statements)

References 37 publications

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“…Here, holoBLG supplementation resulted in a 60% reduction of the TNSS ( 369 ). Moreover, a long-lasting effect was apparent, as even 7 to 8 months later these patients had lower total symptom score and a perceived higher well-being on re-exposure in the allergen exposure chamber, indicating a long-lasting nature of the induced immune resilience ( 370 ).…”

Section: Clinical Studies: Balancing Micronutrient Requirements As a ...mentioning

confidence: 99%

Iron-Deficiency in Atopic Diseases: Innate Immune Priming by Allergens and Siderophores

Roth‐Walter

2022

Front. Allergy

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Although iron is one of the most abundant elements on earth, about a third of the world's population are affected by iron deficiency. Main drivers of iron deficiency are beside the chronic lack of dietary iron, a hampered uptake machinery as a result of immune activation. Macrophages are the principal cells distributing iron in the human body with their iron restriction skewing these cells to a more pro-inflammatory state. Consequently, iron deficiency has a pronounced impact on immune cells, favoring Th2-cell survival, immunoglobulin class switching and primes mast cells for degranulation. Iron deficiency during pregnancy increases the risk of atopic diseases in children, while both children and adults with allergy are more likely to have anemia. In contrast, an improved iron status seems to protect against allergy development. Here, the most important interconnections between iron metabolism and allergies, the effect of iron deprivation on distinct immune cell types, as well as the pathophysiology in atopic diseases are summarized. Although the main focus will be humans, we also compare them with innate defense and iron sequestration strategies of microbes, given, particularly, attention to catechol-siderophores. Similarly, the defense and nutritional strategies in plants with their inducible systemic acquired resistance by salicylic acid, which further leads to synthesis of flavonoids as well as pathogenesis-related proteins, will be elaborated as both are very important for understanding the etiology of allergic diseases. Many allergens, such as lipocalins and the pathogenesis-related proteins, are able to bind iron and either deprive or supply iron to immune cells. Thus, a locally induced iron deficiency will result in immune activation and allergic sensitization. However, the same proteins such as the whey protein beta-lactoglobulin can also transport this precious micronutrient to the host immune cells (holoBLG) and hinder their activation, promoting tolerance and protecting against allergy. Since 2019, several clinical trials have also been conducted in allergic subjects using holoBLG as a food for special medical purposes, leading to a reduction in the allergic symptom burden. Supplementation with nutrient-carrying lipocalin proteins can circumvent the mucosal block and nourish selectively immune cells, therefore representing a new dietary and causative approach to compensate for functional iron deficiency in allergy sufferers.

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Section: Clinical Studies: Balancing Micronutrient Requirements As a ...mentioning

confidence: 99%

Iron-Deficiency in Atopic Diseases: Innate Immune Priming by Allergens and Siderophores

Roth‐Walter

2022

Front. Allergy

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“…87,88 In a real-life situation, several comorbidities, a vegan lifestyle, and so on may reduce the observed efficacy of the food for special medical purposes lozenge. We do not expect that the findings are restricted to female gender, as in an observational trial with house dust mite allergic rhinoconjunctivitis patients, 56 also in men a significant improvement of the symptoms could be recorded, indicating that supplementation in men will similarly calm their immune system.…”

Section: Discussionmentioning

confidence: 92%

“…Three months' supplementation with the holoBLG lozenge had a long-lasting impact, and by 7 to 8 months after the cessation of supplementation, a sustained long-term reduction by 40% of the total symptom score compared with prior supplementation was reported. 56 Here, we went one step further and performed a randomized, double-blind, placebo-controlled trial as a proof of concept, in which we paid particular attention to immune and iron parameters.…”

Section: Discussionmentioning

confidence: 99%

Ameliorating Atopy by Compensating Micronutritional Deficiencies in Immune Cells: A Double-Blind Placebo-Controlled Pilot Study

Bartosik¹,

Jensen²,

Afify³

et al. 2022

The Journal of Allergy and Clinical Immunology: In Practice

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“…In another clinical trial, whey spiked with micronutrients was packed in a lozenge to exploit specifically beta-lactoglobulin as a carrier for iron, vitamin A, and zinc, in order to bring these micronutrients via the lymph system to the immune cells. Consumption of this holoBLG lozenge for 3 months led to an amelioration of allergic symptoms in patients with allergic rhinitis to house dust mites, reducing total nasal symptoms by 60%, and they reported greater perceived wellbeing measurable even up to 8 months after cessation of holoBLG supplementation ( 248 , 249 ) (NCT04477382, NCT04872868, and NCT05455749). Similarly, also in a double-blind, placebo-controlled pilot trial, 6-month supplementation with this holo-BLG lozenge significantly ameliorated symptoms by about 40% over placebo in grass and birch pollen allergic women ( 45 ) (NCT03816800).…”

Section: Dietary Intervention For Disease Prevention and Amelioration...mentioning

confidence: 99%

Lack of iron, zinc, and vitamins as a contributor to the etiology of atopic diseases

et al. 2023

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Micronutritional deficiencies are common in atopic children suffering from atopic dermatitis, food allergy, rhinitis, and asthma. A lack of iron, in particular, may impact immune activation with prolonged deficiencies of iron, zinc, vitamin A, and vitamin D associated with a Th2 signature, maturation of macrophages and dendritic cells (DCs), and the generation of IgE antibodies. In contrast, the sufficiency of these micronutrients establishes immune resilience, promotion of regulatory cells, and tolerance induction. As micronutritional deficiencies mimic an infection, the body’s innate response is to limit access to these nutrients and also impede their dietary uptake. Here, we summarize our current understanding of the physiological function of iron, zinc, and vitamins A and D in relation to immune cells and the clinical consequences of deficiencies in these important nutrients, especially in the perinatal period. Improved dietary uptake of iron is achieved by vitamin C, vitamin A, and whey compounds, whereas zinc bioavailability improves through citrates and proteins. The addition of oil is essential for the dietary uptake of beta-carotene and vitamin D. As for vitamin D, the major source comes via sun exposure and only a small amount is consumed via diet, which should be factored into clinical nutritional studies. We summarize the prevalence of micronutritional deficiencies of iron, zinc, and vitamins in the pediatric population as well as nutritional intervention studies on atopic diseases with whole food, food components, and micronutrients. Dietary uptake via the lymphatic route seems promising and is associated with a lower atopy risk and symptom amelioration. This review provides useful information for clinical studies and concludes/emphasizes that a healthy, varied diet containing dairy products, fish, nuts, fruits, and vegetables as well as supplementing foods or supplementation with micronutrients as needed is essential to combat the atopic march.

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Long-term benefits of targeted micronutrition with the holoBLG lozenge in house dust mite allergic patients

Cited by 11 publications

References 37 publications

Iron-Deficiency in Atopic Diseases: Innate Immune Priming by Allergens and Siderophores

Iron-Deficiency in Atopic Diseases: Innate Immune Priming by Allergens and Siderophores

Ameliorating Atopy by Compensating Micronutritional Deficiencies in Immune Cells: A Double-Blind Placebo-Controlled Pilot Study

Lack of iron, zinc, and vitamins as a contributor to the etiology of atopic diseases

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