Long-term biodiversity intervention shapes health-associated commensal microbiota among urban day-care children

Roslund, Marja I.; Puhakka, Riikka; Nurminen, Noora; Oikarinen, Sami; Siter, Nathan; Grönroos, Mira; Cinek, Ondřej; Kramná, Lenka; Jumpponen, Ari; Laitinen, Olli H.; Rajaniemi, Juho; Hyöty, Heikki; Sinkkonen, Aki; Cerrone, Damiano; Hui, Nan; Mäkelä, Iida; Saarenpää, Mika; Soininen, Laura; Sun, Yan; Vari, Heli K.

doi:10.1016/j.envint.2021.106811

Cited by 57 publications

(49 citation statements)

References 108 publications

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“…The diversity of Proteobacteria and Gammaproteobacteria has been observed to be higher among healthy people compared to people with immune-mediated diseases such as atopy and allergies 4 , 7 , 25 . The diversity of Gammaproteobacteria on skin has successfully been altered via biodiversity intervention with an impact to immune regulation 12 , 13 . The elevation in the diversity of proteobacterial taxa on the skin of participants working in the green wall offices of this study makes sense because Proteobacteria are a common part of plant microbiomes.…”

Section: Discussionmentioning

confidence: 99%

“…These calculations and the subsampling of the samples were done according to the smallest sequence count (3893) in the samples. Contaminant OTUs were removed as in Roslund et al 13 . Abundant bacterial taxa (relative abundance of > 0.01%) were selected for further analyses.…”

Section: Methodsmentioning

confidence: 99%

“…Nature-derived microbes that have a commensal relationship with humans contribute to the development and regulation of the human immune system 1 , 4 , 6 – 8 . The skin microbiome can be altered via skin contact to microbial sources and hands are a common route of microbial transmission 9 – 13 . Indoors, humans affect and are exposed to microbial communities by touching indoor surfaces 14 .…”

Section: Introductionmentioning

confidence: 99%

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Indoor green wall affects health-associated commensal skin microbiota and enhances immune regulation: a randomized trial among urban office workers

Cerrone¹,

Grönroos²,

Luukkonen³

et al. 2022

Sci Rep

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Urbanization reduces microbiological abundance and diversity, which has been associated with immune mediated diseases. Urban greening may be used as a prophylactic method to restore microbiological diversity in cities and among urbanites. This study evaluated the impact of air-circulating green walls on bacterial abundance and diversity on human skin, and on immune responses determined by blood cytokine measurements. Human subjects working in offices in two Finnish cities (Lahti and Tampere) participated in a two-week intervention, where green walls were installed in the rooms of the experimental group. Control group worked without green walls. Skin and blood samples were collected before (Day0), during (Day14) and two weeks after (Day28) the intervention. The relative abundance of genus Lactobacillus and the Shannon diversity of phylum Proteobacteria and class Gammaproteobacteria increased in the experimental group. Proteobacterial diversity was connected to the lower proinflammatory cytokine IL-17A level among participants in Lahti. In addition, the change in TGF-β1 levels was opposite between the experimental and control group. As skin Lactobacillus and the diversity of Proteobacteria and Gammaproteobacteria are considered advantageous for skin health, air-circulating green walls may induce beneficial changes in a human microbiome. The immunomodulatory potential of air-circulating green walls deserves further research attention.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Indoor green wall affects health-associated commensal skin microbiota and enhances immune regulation: a randomized trial among urban office workers

Cerrone¹,

Grönroos²,

Luukkonen³

et al. 2022

Sci Rep

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“…At the same time, an increase in immunomodulatory cytokines and regulatory T cells was observed. The biodiversity intervention was continued up to 2 years and shaped the potentially immunoregulative human microbiota also in long‐term 47 …”

Section: Natural Elements Back To Everyday Lifementioning

confidence: 99%

Biodiversity for resilience—What is needed for allergic children

Haahtela

2022

Pediatric Allergy Immunology

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What is needed for our children facing unprecedented challenges of modern time? Biodiversity, both for immunological and psychological well‐being and resilience. That is also the keyword for the children with allergies and asthma. The cultural evolution with advanced technology and medicine along with major move to urban environment has profoundly changed our lifestyle and surroundings. We are increasingly disconnected from our evolutionary home, soil, natural waters, and air we used to breathe. The ecosystem of human body and mind has been tested, survived, and evolved closely in relation with other ecosystems. For balance and tolerance, immune regulatory circuits need training by microbes, biogenic chemicals, and close relation to natural environment throughout life. This is addressed by the biodiversity hypothesis of tolerance/resilience for health, supported by the pioneering real‐world interventions and a few controlled studies. No need to go “back to nature,” but we must take natural elements back to our everyday life to breathe, eat, drink, and touch. The change for better is plausible and cost‐effective, as shown by the Finnish and other European initiatives, but needs contribution of the whole society.

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“…The microbial contents of the powder were analyzed as triplicates before autoclaving using Illumina MiSeq. 16S rRNA gene metabarcoding with read length 2 × 300 bp using a v3 sequencing reagent kit, as in Hui et al 57 and Roslund et al 58,59 (see Table S1). The raw sequences are publicly available in sequence read as BioProject ID (PRJNA753286).…”

Section: Plant and Soil-based Powdermentioning

confidence: 99%

Effect of inactivated nature‐derived microbial composition on mouse immune system

González-Rodríguez

Nurminen

Kummola

et al. 2021

Immunity Inflam & Disease

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Introduction:The hygiene hypothesis suggests that decrease in early life infections due to increased societal-level hygiene standards subjects one to allergic and autoimmune diseases. In this report, we have studied the effect of sterilized forest soil and plant-based material on mouse immune system and gut microbiome.Methods: Inbred C57Bl/6 mice maintained in normal sterile environment were subjected to autoclaved forest soil-derived powder in their bedding for 1 h a day for 3 weeks. Immune response was measured by immune cell flow cytometry, serum cytokine enzyme-linked immunoassay (ELISA) and quantitative polymerase chain reaction (qPCR) analysis. Furthermore, the mouse gut microbiome was analyzed by sequencing. Results: When compared to control mice, mice treated with soil-derived powder had decreased level of pro-inflammatory cytokines namely interleukin (IL)−17F and IL-21 in the serum. Furthermore, splenocytes from mice treated with soil-derived powder expressed less IL-1b, IL-5, IL-6, IL-13, and tumor necrosis factor (TNF) upon cell activation. Gut microbiome appeared to be stabilized by the treatment.Conclusions: These results provide insights on the effect of biodiversity on murine immune system in sterile environment. Subjecting mice to soil-based plant and microbe structures appears to elicit immune response that could be beneficial, for example, in type 2 inflammation-related diseases, that is, allergic diseases.

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Long-term biodiversity intervention shapes health-associated commensal microbiota among urban day-care children

Cited by 57 publications

References 108 publications

Indoor green wall affects health-associated commensal skin microbiota and enhances immune regulation: a randomized trial among urban office workers

Indoor green wall affects health-associated commensal skin microbiota and enhances immune regulation: a randomized trial among urban office workers

Biodiversity for resilience—What is needed for allergic children

Effect of inactivated nature‐derived microbial composition on mouse immune system

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