Long-term biological fate of polyurethane aortic prostheses

Marinescu, Voinea; Păuşescu, E; Cărnaru, S

doi:10.1136/thx.26.1.108

Cited by 7 publications

(2 citation statements)

References 3 publications

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“…(47) In 1971, Marinescu et al found that when dogs lived years with polyurethane prosthetics, the graft degraded, and a neovessel formed. (48) This then-unseen result spawned ten years of research into polyurethane grafts. (49–54) However, further study found the grafts were not degrading, but eroding.…”

Section: Designs and Progressmentioning

confidence: 99%

Quickening: Translational design of resorbable synthetic vascular grafts

Stowell

Wang

2018

Biomaterials

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Traditional tissue-engineered vascular grafts have yet to gain wide clinical use. The difficulty of scaling production of these cell- or biologic-based products has hindered commercialization. In situ tissue engineering bypasses such logistical challenges by using acellular resorbable scaffolds. Upon implant, the scaffolds become remodeled by host cells. This review describes the scientific and translational advantages of acellular, synthetic vascular grafts. It surveys in vivo results obtained with acellular synthetics over their fifty years of technological development. Finally, it discusses emerging principles, highlights strategic considerations for designers, and identifies questions needing additional research.

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Section: Designs and Progressmentioning

confidence: 99%

Quickening: Translational design of resorbable synthetic vascular grafts

Stowell

Wang

2018

Biomaterials

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“…The use of polyurethanes in medical devices continues to increase, due to their high-quality physical properties and excellent bio-and hemocompatibility. [1][2][3][4][5] Water-dispersible drug-polyurethane systems can be obtained by means of bonding of the drug to polymer matrix. [6][7][8] Recently, there has been an increasing interest in producing nanoscale fibers by employing electrospinning technology for obtaining biocide materials.…”

Section: Introductionmentioning

confidence: 99%

Electrospun/electrosprayed polyurethane biomembranes with ciprofloxacin and clove oil extract for urinary devices

Macocinschi¹,

Filip²,

Vlad³

et al. 2015

Journal of Bioactive and Compatible Polymers

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Polyurethane–eugenol solutions in N,N-dimethyl formamide were electrospun/electrosprayed onto polyurethane–ciprofloxacin biomembranes to obtain drug delivery systems for urinary devices. Following electrospinning/electrospraying, particle-fiber morphology was evidenced by scanning electronic microscope analysis. Contact angle determinations along with surface free energy calculations, moisture diffusion test, and diffusion coefficient determinations were done for polyurethane–ciprofloxacin biomembranes. Determination of bioactive ciprofloxacin release kinetics evidences non-Fickian/anomalous/diffusion mechanism, coupling Fickian diffusion with the relaxation of the polymeric chains within the matrix network. A slight increase in n values for electrospun/electrosprayed coated samples evidenced a behavior closer to a case II transport mechanism with zero-order kinetics. The biological activity of the electrospun/electrosprayed polyurethane membrane samples tested against Staphylococcus aureus, Sarcina lutea, Bacillus cereus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa showed comparable antibacterial activity with standard ciprofloxacin.

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Small‐caliber polyurethane and polytetrafluoroethylene grafts: A comparative study in a canine aortoiliac model

Stanley

Burkel

Graham

1990

J. Biomed. Mater. Res.

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In vivo stability of a new small-caliber polyurethane graft (n8) was assessed in a canine aortoiliac model and compared to that of a conventional expanded polytetrafluoroethylene (ePTFE) graft (n8). Six months following implantation, marked aneurysmal dilatation to 230 +/- 80% (mean +/- SD) of the original diameter occurred in polyurethane grafts, while dilatation to 110 +/- 8% of the original diameter occurred in ePTFE grafts (p less than 0.005). Interval patency was 75% for each graft type. Luminal thrombus affected 59% of polyurethane graft surfaces compared to 22% of ePTFE graft surfaces (p less than 0.01). Qualitative examination of representative sections of polyurethane conduits demonstrated thick inner capsules with numerous small islands of graft material surrounded by macrophages and bands of mature fibrous tissue, in contrast to the thinner neointima and limited anastomotic pannus ingrowth observed in ePTFE grafts.

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Long-term biological fate of polyurethane aortic prostheses

Cited by 7 publications

References 3 publications

Quickening: Translational design of resorbable synthetic vascular grafts

Quickening: Translational design of resorbable synthetic vascular grafts

Electrospun/electrosprayed polyurethane biomembranes with ciprofloxacin and clove oil extract for urinary devices

Small‐caliber polyurethane and polytetrafluoroethylene grafts: A comparative study in a canine aortoiliac model

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