Long-term change in alcohol-consumption status and variations in fibrinogen levels: the coronary artery risk development in young adults (CARDIA) study

Okwuosa, Tochi M.; Klein, Oana L.; Chan, Cheeling; Schreiner, Pamela J.; Liu, Kiang

doi:10.1136/bmjopen-2013-002944

Cited by 7 publications

(3 citation statements)

References 27 publications

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“…Other researchers have proposed that low fibrinogen levels in individuals with moderate alcohol intake were associated with reduced cardiovascular mortality. 35 , 36 Interestingly, in our study population, among the patients with AUD, those with the highest fibrinogen levels had the lowest alcohol consumption levels at admission. In addition, compared with those with low fibrinogen levels, those with higher fibrinogen levels had a lower prevalence of other markers of poor prognosis, like HCV infection, or presence of ARLD.…”

Section: Discussionmentioning

confidence: 56%

Markers of Inflammation and Mortality in a Cohort of Patients With Alcohol Dependence

et al. 2015

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Inflammation and intestinal permeability are believed to be paramount features in the development of alcohol-related liver damage. We aimed to assess the impact of 3 surrogate markers of inflammation (anemia, fibrinogen, and ferritin levels) on mid-term mortality of patients with alcohol dependence.This longitudinal study included patients with alcohol dependence admitted for hospital detoxification between 2000 and 2010. Mortality was ascertained from clinical charts and the mortality register. Associations between markers of inflammation and all-cause mortality were analyzed with mortality rates and Cox proportional hazards regression models.We also performed a subgroup analysis of mortality rates in patients with anemia, based on their mean corpuscular volume (MCV).We included 909 consecutive patients with alcohol dependence. Patients were mostly male (80.3%), had a median age of 44 years (interquartile range [IQR]: 38–50), and upon admission, their median alcohol consumption was 192 g/day (IQR: 120–265). At admission, 182 (20.5%) patients had anemia; 210 (25.9%) had fibrinogen levels >4.5 mg/dL; and 365 (49.5%) had ferritin levels >200 ng/mL. At the end of follow-up (median 3.8 years [IQR: 1.8–6.5], and a total of 3861.07 person-years), 118 patients had died (12.9% of the study population). Cox regression models showed that the presence of anemia at baseline was associated with mortality (hazard ratio [HR]: 1.67, 95% confidence interval [CI]: 1.11–2.52, P < 0.01); no associations were found between mortality and high fibrinogen or high ferritin levels.A subgroup of patients with anemia was analyzed and compared to a control group of patients without anemia and a normal MCV. The mortality ratios of patients with normocytic and macrocytic anemia were 3.25 (95% CI: 1.41–7.26; P < 0.01) and 3.39 (95% CI: 1.86–6.43; P < 0.01), respectively.Patients with alcohol dependence admitted for detoxification had an increased risk of death when anemia was present at admission. More accurate markers of systemic inflammation are needed to serve as prognostic factors for poor outcomes in this subset of patients.

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Section: Discussionmentioning

confidence: 56%

Markers of Inflammation and Mortality in a Cohort of Patients With Alcohol Dependence

et al. 2015

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“…There is also data that suggests that the consumption of alcohol at a younger age does reduce the risk of CVD at a later age [98][99][100][101] by modulating certain biomarkers for CVD.…”

Section: Effect Of Age On the Relationship Between Alcohol Consumptiomentioning

confidence: 99%

The relationships between alcohol, wine and cardiovascular diseases –A review

Stockley¹

2016

NUA

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Abstract.The relationship between alcohol consumption and the risk of cardiovascular disease has now been studied for over fifty years, and confirmed in multiples case-controlled and cohort studies, and subsequent meta-analyses of these studies. Sound experimental and clinical studies of plausible biological mechanisms support that there is a causal relationship between alcoholic beverages and cardiovascular disease. While beer, wine and spirits all contain alcohol, they are not necessarily equal in their effects on cardiovascular health, such as the incidence and mortality of coronary heart disease, stroke and all-cause mortality. Hence this review evaluates the available evidence, and details the biological mechanisms and attributes a percentage reduction in harm where possible.

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“…Several epidemiological studies have shown J-shape relations between alcohol consumption and all-cause mortality and cardiovascular events in women [4][5][6]. Alcohol drinking similarly has effects on the lipid profile [7][8][9], glycometabolism [10,11], and coagulation fibrinolysis system [12][13][14] in both sexes.…”

Section: Introductionmentioning

confidence: 99%

Endothelial function is preserved in light to moderate alcohol drinkers but is impaired in heavy drinkers in women: Flow-mediated Dilation Japan (FMD-J) study

et al. 2020

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Light to moderate alcohol consumption has protective effects on all-cause death and coronary artery disease in women. It is thought that light to moderate alcohol consumption has a beneficial effect on vascular function in women. We measured flow-mediated vasodilation (FMD) in 702 women aged 17–86 years who provided information on alcohol consumption. We divided the subjects into four groups: non-drinkers (0 g/week), light drinkers (>0 to 140 g/week), moderate drinkers (>140 to 280 g/week) and heavy drinkers (>280 g/week). There was no significant difference in FMD among the four groups. Multivariate regression analysis revealed that alcohol consumption in non-drinkers and light drinkers was not an independent predictor of FMD (β = −0.001, P = 0.98). We compared 50 moderate drinkers and 50 non-drinkers matched for age and medical histories and 22 heavy drinkers and 22 non-drinkers in matched pair analysis. There was no significant difference in FMD between moderate drinkers and non-drinkers (8.2±4.3% vs. 8.1±3.5, P = 0.91), while FMD in heavy drinkers was significantly lower than that in non-drinkers (5.9±2.5% vs. 8.9±3.5%, P = 0.002). These findings suggest that heavy alcohol consumption is associated with endothelial dysfunction but that light to moderate alcohol consumption is not associated with endothelial dysfunction in women. Clinical trial registration information This study was approved by principal authorities and ethical issues in Japan (University Hospital Medical Information Network UMIN000012952, 01/12/2009). www.umin.ac.jp/.

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Long-term change in alcohol-consumption status and variations in fibrinogen levels: the coronary artery risk development in young adults (CARDIA) study

Cited by 7 publications

References 27 publications

Markers of Inflammation and Mortality in a Cohort of Patients With Alcohol Dependence

Markers of Inflammation and Mortality in a Cohort of Patients With Alcohol Dependence

The relationships between alcohol, wine and cardiovascular diseases –A review

Endothelial function is preserved in light to moderate alcohol drinkers but is impaired in heavy drinkers in women: Flow-mediated Dilation Japan (FMD-J) study

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