Long-Term Clinical and Biochemical Follow-up in Medullary Thyroid Carcinoma

Abstract

The chance to achieve biochemical cure in MTC is clearly dependent on the primary tumor size. The chance for long-term biochemical cure in a pT4-tumor is almost nil even after multiple and extended reoperations, whereas a pT1 tumor can be cured in up to 67% of the patients. Long-term survival, however, can be achieved even in pT4 tumor patients in almost 50%.

Retrospective analysis of 140 cases of medullary thyroid carcinoma followed-up in a single institution

“…Specific survival at 5 and 10 years in the present cohort was 79.3 and 73.6%, respectively, which was similar to previous reports (16,19,20,22,23). Another possible adverse prognostic factor identified in the present study was age >45 years.…”

“…Of the 140 patients included in the present study, only 11% represented familial cases, which indicates a prevalence significantly lower than that reported by others (6,(16)(17)(18)(19). However, the present study only included patients with MTC confirmed by histology, which may have underestimated the total number of familial cases.…”

“…The present cohort consisted of a considerable number of MTC patients followed-up in a single institution (and therefore, with uniform criteria for collecting data) and with a median follow-up time similar to other published studies (6,16). However, the current study presents certain limitations: i) It is a retrospective analysis that included patients referred from other institutions; thus, it was not possible to retrieve certain information for these patients.…”

Validity of 6^th edition of UICC TNM classification system for medullary thyroid carcinoma: A proposal for intraoperative evaluation of T category

“…In such circumstances, 10-and 20-year disease-free survival rates of our MTC series were 89 and 82.5%, respectively, and cause-specific survival rates were 96.6 and 91.7%, respectively [18]. These survival rates were better than those reported in Western countries [3,4,[10][11][12][13][14][19][20][21][22][23]. In our series, extrathyroid extension, lymph node metastasis, and a large tumor size were regarded as prognostic factors, while gender, age, and RET gene mutations (except for MEN 2B) did not affect patients' prognoses [18].…”

Cáncer medular de tiroides: Experiencia quirúrgica en 10 años

“…En nuestra serie a todos los pacientes con diagnóstico pre operatorio de CMT se les realizó TT asociada a disección cervical, cuya extensión se determinó según el tamaño del tumor y la presencia de linfonodos sospechosos en la ecografía preoperatoria, como se expuso en los resultados. Respeto a las características anátomo-patológicas de nuestra serie, el tamaño tumoral promedio fue de 1,8 cm, lo que es menor a lo reportado por otros grupos 3,15,27 , lo mismo ocurrió con la incidencia de compromiso linfonodal presente sólo en 20,8% de nuestros pacientes al momento del diagnóstico, el cual es reportado por distintas series entre 30-60% de los casos 3,15,27 . Dichas diferencias podrían explicarse por el diagnóstico precoz de nuestros pacientes, ya que 78,5% de ellos se presentó en etapa I y II.…”