Long‐term clinical response to treatment and maintenance of localized aggressive periodontitis: a cohort study

Abstract

Aim To evaluate long-term clinical response to periodontal therapy and maintenance in localized aggressive periodontitis (LAP). Materials and Methods One hundred forty-one African-Americans diagnosed with LAP, aged 5–25 years, were enrolled. Patients underwent periodontal mechanical debridement plus one week of amoxicillin/metronidazole. Mechanical therapy was repeated as needed and clinical parameters were recorded at baseline, 3, 6, 12, 18, and 24 months, and 2 additional annual follow-up visits after treatment. Radiographs from primary dentition of patients with LAP in permanent dentition, and additional healthy siblings (HS) were analyzed retrospectively. Results Periodontal therapy significantly improved probing depth and clinical attachment level up to 4 years (mean reductions: 2.18 ± 1.03 and 2.80 ± 1.43 mm, respectively). Percentage of affected sites was reduced at all timepoints and maintained up to 4 years. Noncompliance with antibiotics/appointments negatively affected the treatment response. Ninety percent of LAP patients in permanent dentition and 32% of HS presented radiographic bone loss in primary dentition. Conclusions Mechanical debridement with one-week of systemic antibiotics along with proper periodontal maintenance was effective in the treatment and successful maintenance of LAP for up to 4 years. LAP in permanent dentition may be preceded in the primary dentition. Clinicaltrials.gov #NCT01330719.

Non‐Surgical Therapy Reduces Presence of JP2 Clone in Localized Aggressive Periodontitis

“…These correlations presented here provide further evidence for implication of the JP2 genotype as an associated pathogen in LAgP disease, attesting for the first time the effectiveness of this non‐surgical treatment protocol for this population at 12 months after therapy. In fact, long‐term clinical benefits and 4‐year maintenance of this treatment protocol has been previously reported for all patients with LAgP in another trial 36 . It is noteworthy that this is a one‐time regimen of antibiotics for treatment of this population at baseline, and the patients are followed by regular maintenance after this treatment.…”

“…In fact, longterm clinical benefits and 4-year maintenance of this treatment protocol has been previously reported for all patients with LAgP in another trial. 36 It is noteworthy that this is a one-time regimen of antibiotics for treatment of this population at baseline, and the patients are followed by regular maintenance after this treatment. Thus, significant reduction of this pathogen in the long term with one-time antibiotic use is of extreme clinical benefit for this disease.…”

Clinical Characteristics of Localized Aggressive Periodontitis in Primary Dentition

“…A retrospective analysis of permanent dentition cases of our studied population showed that out of 23 cases of LAP in permanent dentition that previous radiographs could be obtained from their primary dentition ages, onset of bone loss at primary dentition was observed in 20 of them (87%), affecting them as early as 5 years of age. 14 Thus, treatment of this disease at early stages could prevent the progression of disease into permanent teeth, as suggested previously. 13,15,16 …”

Periodontal regeneration with enamel matrix derivative in the management of generalized aggressive periodontitis: A case report with 11-year follow-up and literature review

“…In fact, several authors documented clinical improvement in PD, PAL, and BOP. [1718] Mongardini et al . compared the effectiveness between FMDP and conventional treatment in 16 patients with AgP (referred as early-onset periodontitis) and ascertained small but significant differences in periodontal indexes over an 8-month period.…”