Long–Term Comparison of Fibrin Tissue Glue and Vicryl Suture in Conjunctival Autografting for Pterygium Surgery

Çağatay, Halil Hüseyin; Gökçe, Gökçen; Ekinci, Metin; Koban, Yaran; Daraman, Özlem; Ceylan, Erdinç

doi:10.3810/pgm.2014.01.2729

Cited by 20 publications

(22 citation statements)

References 27 publications

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“…249 There were three cohort studies, 243,245,249 three comparative studies 242,244,247 and two reviews of patient records. 246,248 The following fibrin sealants were used: unspecified fibrin glue in eye surgery, [242][243][244] Tiseel, 245 Beriplast, 247 aerosolised fibrin glue 248 and platelet-enriched fibrin glue sealant. 249 Comparator interventions were standard care [245][246][247][248][249] or sutures in eye surgery.…”

Section: Quantity Of Observational Studies and Regulatory Body Reportsmentioning

confidence: 99%

“…249 Comparator interventions were standard care [245][246][247][248][249] or sutures in eye surgery. [242][243][244] Sample sizes ranged from 40 243 to 529 246 participants.…”

Section: Quantity Of Observational Studies and Regulatory Body Reportsmentioning

confidence: 99%

“…Three observational studies were in eye surgery, [242][243][244] three in upper GI tract surgery, [245][246][247] one in plastic/ reconstructive surgery 248 and one in vascular surgery. 249 There were three cohort studies, 243,245,249 three comparative studies 242,244,247 and two reviews of patient records. 246,248 The following fibrin sealants were used: unspecified fibrin glue in eye surgery, [242][243][244] Tiseel, 245 Beriplast, 247 aerosolised fibrin glue 248 and platelet-enriched fibrin glue sealant.…”

Section: Quantity Of Observational Studies and Regulatory Body Reportsmentioning

confidence: 99%

“…There were an additional 93 reports, reviews or notifications about harms from the use of these products from the MHRA, EMA and FDA websites. After screening and applying the eligibility criteria, eight observational studies were included [242][243][244][245][246][247][248][249] (Table 18). Three observational studies were in eye surgery, [242][243][244] three in upper GI tract surgery, [245][246][247] one in plastic/ reconstructive surgery 248 and one in vascular surgery.…”

Section: Quantity Of Observational Studies and Regulatory Body Reportsmentioning

confidence: 99%

“…After screening and applying the eligibility criteria, eight observational studies were included [242][243][244][245][246][247][248][249] (Table 18). Three observational studies were in eye surgery, [242][243][244] three in upper GI tract surgery, [245][246][247] one in plastic/ reconstructive surgery 248 and one in vascular surgery. 249 There were three cohort studies, 243,245,249 three comparative studies 242,244,247 and two reviews of patient records.…”

Section: Quantity Of Observational Studies and Regulatory Body Reportsmentioning

confidence: 99%

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The use of fibrin sealant during non-emergency surgery: a systematic review of evidence of benefits and harms

Edwards¹,

Crawford²,

Velthoven³

et al. 2016

Health Technol Assess

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BackgroundFibrin sealants are used in different types of surgery to prevent the accumulation of post-operative fluid (seroma) or blood (haematoma) or to arrest haemorrhage (bleeding). However, there is uncertainty around the benefits and harms of fibrin sealant use.ObjectivesTo systematically review the evidence on the benefits and harms of fibrin sealants in non-emergency surgery in adults.Data sourcesElectronic databases [MEDLINE, EMBASE and The Cochrane Library (including the Cochrane Database of Systematic Reviews, the Database of Abstracts of Reviews of Effects, the Health Technology Assessment database and the Cochrane Central Register of Controlled Trials)] were searched from inception to May 2015. The websites of regulatory bodies (the Medicines and Healthcare products Regulatory Agency, the European Medicines Agency and the Food and Drug Administration) were also searched to identify evidence of harms.Review methodsThis review included randomised controlled trials (RCTs) and observational studies using any type of fibrin sealant compared with standard care in non-emergency surgery in adults. The primary outcome was risk of developing seroma and haematoma. Only RCTs were used to inform clinical effectiveness and both RCTs and observational studies were used for the assessment of harms related to the use of fibrin sealant. Two reviewers independently screened all titles and abstracts to identify potentially relevant studies. Data extraction was undertaken by one reviewer and validated by a second. The quality of included studies was assessed independently by two reviewers using the Cochrane Collaboration risk-of-bias tool for RCTs and the Centre for Reviews and Dissemination guidance for adverse events for observational studies. A fixed-effects model was used for meta-analysis.ResultsWe included 186 RCTs and eight observational studies across 14 surgical specialties and five reports from the regulatory bodies. Most RCTs were judged to be at an unclear risk of bias. Adverse events were inappropriately reported in observational studies. Meta-analysis across non-emergency surgical specialties did not show a statistically significant difference in the risk of seroma for fibrin sealants versus standard care in 32 RCTs analysed [n = 3472, odds ratio (OR) 0.84, 95% confidence interval (CI) 0.68 to 1.04;p = 0.13;I2 = 12.7%], but a statistically significant benefit was found on haematoma development in 24 RCTs (n = 2403, OR 0.62, 95% CI 0.44 to 0.86;p = 0.01;I2 = 0%). Adverse events related to fibrin sealant use were reported in 10 RCTs and eight observational studies across surgical specialties, and 22 RCTs explicitly stated that there were no adverse events. One RCT reported a single death but no other study reported mortality or any serious adverse events. Five regulatory body reports noted death from air emboli associated with fibrin sprays.LimitationsIt was not possible to provide a detailed evaluation of individual RCTs in their specific contexts because of the limited resources that were available for this research. In addition, the number of RCTs that were identified made it impractical to conduct independent data extraction by two reviewers in the time available.ConclusionsThe effectiveness of fibrin sealants does not appear to vary according to surgical procedures with regard to reducing the risk of seroma or haematoma. Surgeons should note the potential risk of gas embolism if spray application of fibrin sealants is used and not to exceed the recommended pressure and spraying distance. Future research should be carried out in surgery specialties for which only limited data were found, including neurological, gynaecological, oral and maxillofacial, urology, colorectal and orthopaedics surgery (for any outcome); breast surgery and upper gastrointestinal (development of haematoma); and cardiothoracic heart or lung surgery (reoperation rates). In addition, studies need to use adequate sample sizes, to blind participants and outcome assessors, and to follow reporting guidelines.Study registrationThis study is registered as PROSPERO CRD42015020710.FundingThe National Institute for Health Research Health Technology Assessment programme.

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Section: Quantity Of Observational Studies and Regulatory Body Reportsmentioning

confidence: 99%

“…249 Comparator interventions were standard care [245][246][247][248][249] or sutures in eye surgery. [242][243][244] Sample sizes ranged from 40 243 to 529 246 participants.…”

Section: Quantity Of Observational Studies and Regulatory Body Reportsmentioning

confidence: 99%

Section: Quantity Of Observational Studies and Regulatory Body Reportsmentioning

confidence: 99%

Section: Quantity Of Observational Studies and Regulatory Body Reportsmentioning

confidence: 99%

Section: Quantity Of Observational Studies and Regulatory Body Reportsmentioning

confidence: 99%

See 3 more Smart Citations

The use of fibrin sealant during non-emergency surgery: a systematic review of evidence of benefits and harms

Edwards¹,

Crawford²,

Velthoven³

et al. 2016

Health Technol Assess

View full text Add to dashboard Cite

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Comparison of efficacy of three surgical methods of conjunctival autograft fixation in the treatment of pterygium

et al. 2014

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Our aim primarily was to compare the recurrence rate with three techniques of conjunctival fixation (suture versus fibrin glue versus autologous in situ blood coagulum) over bare sclera following pterygium excision. Ninety eyes of 90 patients with primary pterygium were randomly divided into three groups: group I (30 eyes) underwent autografting and fixation with 8-0 vicryl sutures, group II (30 eyes) with fibrin glue and group III (30 eyes) with autologous in situ blood coagulum. The patients were reviewed on 2nd day, weeks 1 and 4, and at every 3 months till 12 months after surgery. Rate of recurrence was similar (p = 0.585) across the three groups. Time taken for surgery for Group 1 was more as compared to group 2 (p < 0.001) and group 3 (p < 0.001). Also, group 2 cases took significantly more time as compared to group 3 (p < 0.001). Postoperative patient discomfort (foreign body sensation, epiphora, pain and irritation) was more in suture-assisted autografting as compared to the other two groups. However, at some points along the time line, patient discomfort was significantly more in group III as compared to group II. Complications like graft retraction, graft displacement and cyst formation were seen in a few patients but were not statistically significant across the three groups. All three techniques were found to be useful methods and were associated with similar rate of recurrence.

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Self-made cryopreservative fibrin glue applied in pterygium surgery: a novel practical technique

et al. 2017

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Long–Term Comparison of Fibrin Tissue Glue and Vicryl Suture in Conjunctival Autografting for Pterygium Surgery

Cited by 20 publications

References 27 publications

The use of fibrin sealant during non-emergency surgery: a systematic review of evidence of benefits and harms

The use of fibrin sealant during non-emergency surgery: a systematic review of evidence of benefits and harms

Comparison of efficacy of three surgical methods of conjunctival autograft fixation in the treatment of pterygium

Self-made cryopreservative fibrin glue applied in pterygium surgery: a novel practical technique

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