Long-Term Course of Haemoglobin and Ferritin Values in High-Frequency Donors of Whole Blood and Double Erythrocyte Apheresis

Pehlic, Vildana; Volken, Thomas; Holbro, Andreas; Jirout, Zuzana; Drexler, Beatrice; Buser, Andreas; Infanti, Laura

doi:10.1159/000509026

Cited by 7 publications

(5 citation statements)

References 25 publications

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“…34 who donated more often tend to be older, which otherwise associates with higher ferritin levels, as shown in Figure 2 and previous research. 36,37 The large amount of data from many individual donors enabled us to not only compare ferritin levels from regular donors to nondonors, or from frequent to less-frequent donors, but to establish linear associations of donation numbers with (log-)ferritin levels in a real-life observational setting.…”

Section: Discussionmentioning

confidence: 99%

Donation‐induced iron depletion is significantly associated with low hemoglobin at subsequent donations

et al. 2021

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Background: Blood donation is associated with a loss of hemoglobin (Hb)-bound iron. Hb levels recover relatively fast by using stored iron. However, it takes more time to replenish iron stores, potentially resulting in iron deficiency.Study design: Hb and ferritin levels were measured in 5056 new, first-time, and repeat whole blood donors. We investigated whether increasing numbers of donations are associated with lower ferritin levels. Furthermore, we tested whether low ferritin levels are associated with low-Hb deferral at the subsequent donation attempt by performing logistic regression adjusted for age and stratified by sex. Results: Whereas mean Hb levels are relatively stable, ferritin levels significantly decrease with increasing numbers of donations and were approximately 50% lower for donors with >50 donations compared with those with 2-10 donations. Despite the poor correlation of ferritin and Hb levels, cross-sectional, iron-deficient donors (ferritin <15 ng/ml) had 21.8 (8.5-55.6) higher odds in men, 10.1 (6.1-16.5) in premenopausal women, and 11.7 (5.2-26.4) in postmenopausal women for Hb deferral at a subsequent visit.Discussion: To conclude, repeated donations may induce iron deficiency, which corresponds with an over tenfold increased risk of having insufficiently restored Hb levels at a subsequent donation attempt. Longer donation intervals and/or higher dietary or supplemental iron intake are warranted to prevent accumulated iron depletion and subsequent low-Hb deferral in whole blood donors.

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Section: Discussionmentioning

confidence: 99%

Donation‐induced iron depletion is significantly associated with low hemoglobin at subsequent donations

et al. 2021

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“…The phenomenon of iron depletion after blood donation is well known. One donation of two‐unit RBC is associated with an iron loss of roughly 320 to 420 mg 6,28,29 . Literature reports lots of donors delayed blood donation after 2 RBC due to iron deficiency 30,31 .…”

Section: Discussionmentioning

confidence: 99%

“…27 The phenomenon of iron depletion after blood donation is well known. One donation of two-unit RBC is associated with an iron loss of roughly 320 to 420 mg. 6,28,29 Literature reports lots of donors delayed blood donation after 2 RBC due to iron deficiency. 30,31 Sherman et al 10 reported that Hb was still significantly lower than baseline levels at 16 weeks after 2-RBC (400 mL) without iron supplementation.…”

Section: Discussionmentioning

confidence: 99%

Investigation on the feasibility of large‐volume autologous red blood cells donation: A pilot trial in a small cohort of Chinese

Chen

Wang

et al. 2023

J of Clinical Apheresis

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Background: Preoperative autologous blood donation (PAD) is used for elective surgical procedures with a predictable blood loss. But a downward trend in PAD is due to the fact that patients with preoperative whole blood donation or two-unit red cell apheresis cannot avoid receiving allogenic blood during intensive surgery. To improve the clinical application of PAD, this study explores the feasibility of large-volume autologous red blood cells (RBCs) donation by a pilot trial in a small cohort of Chinese.Methods: This was a single-center, prospective study and 16 male volunteers were enrolled from May to October in 2020. Each volunteer donated 627.25 ± 109.74 mL (mean ± SD) RBC with apheresis machine or manually, and received 800 mg of intravenous iron in four divided doses. Blood pressure, oxygen saturation (SpO 2 ), respiratory rate and heart rate were monitored throughout the procedure. The RBC count, hemoglobin (Hb) concentration, hematocrit (Hct), reticulocyte count, erythropoietin (Epo), serum iron, total iron binding capacity (TIBC), transferrin saturation, transferrin, and ferritin were dynamically detected and analyzed before and 8 weeks after blood donation.Results: There was no differences in SpO 2 , systolic and diastolic blood pressure before and after blood collection (P ≥ .05). The heart rate and respiratory rate after donation were slightly lower than those before (P < .05). The level of RBC, Hb concentration and Hct fell to a nadir on Day 3 (pre-donation vs post-

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“…In contrast, a study of plasma donors found that iron deficiency was rare and not more common in high-frequency donors [26]. Recent findings indicating that with 24-week intervals between double red cell donations, young men maintain stable hemoglobin and ferritin over several years [27 ▪▪ ], which may be attributable to stringent minimum weight and hemoglobin eligibility criteria.…”

Section: Prevalence Of Iron Deficiency In Blood Donorsmentioning

confidence: 96%

Iron status of blood donors

Spencer

Mast

2022

Current Opinion in Hematology

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Purpose of reviewThis review examines recent research on the prevalence and importance of iron deficiency in blood donors, and on efforts to mitigate it. Recent findingsPremenopausal females, teenagers, and high-frequency donors are at the highest risk for donation-induced iron deficiency, in both high-resource and low-resource settings. The physiology relating iron stores to hemoglobin levels and low hemoglobin deferral is well elucidated in blood donor populations, yet the clinical effects attributable to iron loss in the absence of anemia are challenging to identify. Expanded adoption of ferritin testing is improving donor management but may cause decreases in the blood supply from temporary donor loss. The potential for personalized donor management is emerging with development of computational models that predict individual interdonation intervals that aim to optimize blood collected from each donor while minimizing low hemoglobin deferrals. SummaryMeasures to reduce iron deficiency are available that can be deployed on a standardized or, increasingly, personalized basis. Blood centers, regulators, and donors should continue to evaluate different tactics for addressing this problem, to obtain a balanced approach that is optimal for maintaining adequate collections while safeguarding donor health.

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Long-Term Course of Haemoglobin and Ferritin Values in High-Frequency Donors of Whole Blood and Double Erythrocyte Apheresis

Cited by 7 publications

References 25 publications

Donation‐induced iron depletion is significantly associated with low hemoglobin at subsequent donations

Donation‐induced iron depletion is significantly associated with low hemoglobin at subsequent donations

Investigation on the feasibility of large‐volume autologous red blood cells donation: A pilot trial in a small cohort of Chinese

Iron status of blood donors

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