Long term course of tear gland function in patients with keratoconjunctivitis sicca and Sjogren's syndrome

Kruize, A.A.; Bijsterveld, O. P. Van; Hené, Ronald J.; Wilde, P.C.M. de; Feltkamp, T. E. W.; Kater, L.; Bijlsma, J. W. J.

doi:10.1136/bjo.81.6.435

Cited by 24 publications

(15 citation statements)

References 15 publications

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“…Although our findings agree with previous work, 6,8 some studies have discriminated KCS from SS based on Schirmer scores. 29 Thus, while tear flow may prove useful in a broad separation of AD dry eye from NDE subjects, standard practice suggests the combination of several tests, including biomarker quantitation, are performed to increase the sensitivity and selectivity required for adequate differential diagnosis. 6,23,24 Age may have been a factor in our results.…”

Section: Discussionmentioning

confidence: 99%

Tear Lipocalin and Lysozyme in Sjögren and Non-Sjogren Dry Eye

Caffery

Joyce

Boone

et al. 2008

Optometry and Vision Science

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Our data demonstrate a biochemical distinction between the Sjögren's group compared with both KCS and control groups, in that both tear lipocalin and total tear protein were significantly reduced. Although correlations were not found between protein measurements and tear flow, a combination of tests including Schirmer I and quantitation of tear film biomarkers may allow for the identification of SS patients without the need for invasive testing.

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Section: Discussionmentioning

confidence: 99%

Tear Lipocalin and Lysozyme in Sjögren and Non-Sjogren Dry Eye

Caffery

Joyce

Boone

et al. 2008

Optometry and Vision Science

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“…Lactoferrin is a single-chain polipeptide with important bacteriostatic activity, 20 which also represents an index of lachrymal gland function. Its determination in tears has been conducted in the past by techniques, 21,22 currently abandoned. In this work, we have shown a low but significant lactoferrin decrease in mild EDE patients vs controls without observing changes in the lysozyme content; data would suggest an initial impairment of the lachrymal gland function, not yet detected by the Schirmer test.…”

Section: Discussionmentioning

confidence: 99%

“…For patients, the inclusion criteria were a Schirmer test I value higher than 10 mm/5 min, a tear film break-up time (TFBUT) value p10 s, mild subjective symptoms of ocular discomfort as evaluated by an OSDI questionnaire 11 (score [12][13][14][15][16][17][18][19][20][21][22][23][24], and use of tear substitutes only, for treatment, which were suspended for at least 3 days before tear collection.…”

Section: Subjectsmentioning

confidence: 99%

Tear proteomics in evaporative dry eye disease

Versura

Nanni

Bavelloni

et al. 2010

Eye

143

114

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Purpose: To analyze tear protein variations in patients suffering from dry eye symptoms in the presence of tear film instability but without epithelial defects. Methods: Five microlitres of non-stimulated tears from 60 patients, suffering from evaporative dry eye (EDE) with a break-up time (BUT) o10 s, and from 30 healthy subjects as control (no symptoms, BUT 410 s) were collected. Tear proteins were separated by mono and bi-dimensional SDS-PAGE electrophoresis and characterized by immunoblotting and enzymatic digestion. Digested peptides were analyzed by liquid chromatography coupled to electrospray ionization quadrupole-time of flight mass spectrometry followed by comparative data analysis into Swiss-Prot human protein database using Mascot. Statistical analysis were performed by applying a t-test for independent data and a MannWhitney test for unpaired data (Po0.05). Results: In EDE patients vs controls, a significant decrease in levels of lactoferrin (data in % ± SD): 20.15 ± 2.64 vs 24.56 ± 3.46 (P ¼ 0.001), lipocalin-1: 14.98±2.70 vs 17.73±2.96 (P ¼ 0.0001), and lipophilin A-C: 2.89±1.06 vs 3.63±1.37 (P ¼ 0.006) was revealed, while a significant increase was observed for serum albumin: 9.45 ± 1.87 vs 3.46 ± 1.87 (P ¼ 0.0001). No changes for lysozyme and zinc a-2 glycoprotein (P ¼ 0.07 and 0.7, respectively) were shown. Proteomic analysis showed a downregulation of lipophilin A and C and lipocalin-1 in patients, which is suggested to be associated with post-translational modifications. Conclusions: Data show that tear protein changes anticipate the onset of more extensive clinical signs in early stage dry eye disease.

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“…Bortsett fra den økte lymfomrisikoen er prognosen med henblikk på mortalitet og alvorlig morbiditet relativt god. Når det gjelder eksokrin funksjon, spesielt spytt-og tåreproduksjon ser det ut til å vaere et stabilt forløp for de fleste [51][52][53] . Dette kan henge sammen med at det største tapet av funksjon antaglig skjer i et svaert tidlig stadium av sykdommen 54 .…”

Section: Mortalitet Og Kreftrisikounclassified

Sjögrens syndrom

Brun¹,

Jönsson²

2009

Nor J Epidemiol

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ENGLISH SUMMARYBrun JG, Jonsson R. Sjögren's syndrome. Nor J Epidemiol 2008; 18 (1): 67-72.Sjögren's syndrome has been defined as a chronic inflammatory and lymphoproliferative disease with autoimmune features characterized by a progressive mononuclear cell infiltration of exocrine glands, notably the lacrimal and salivary glands (autoimmune exocrinopathy). Estimates of prevalence and incidence have varied widely according to case finding methods and criteria used. The recent American-European Consensus Group criteria has attained a wide acceptance internationally. According to these criteria the prevalence of Sjögren's syndrome is between 0.1-0.6%, and the incidence between 3 and 6 per 100.000 per year. The female:male ratio is 9:1. In addition to gender, autoimmune disease among first degree relatives and previous births have been identified as risk factors. Large population-based prospective studies are needed to identify life style risk factors. There is no strong evidence for a specific genetic component in SS and therefore a need for national and international collaborative efforts on association studies in large patient populations. Except for an increased risk of non-Hodgkin lymphoma mortality is not increased. Some predisposing factors for lymphoma have been identified. Exocrine function is decreased but usually stable, except for pasients with intitially low salivary flow or high focus scores. Secondary Sjögren's syndrome may occur in 10-30% of patients with other inflammatory systemic diseases. INNLEDNINGSjögrens syndrom er antaglig den hyppigste autoimmune revmatiske systemsykdommen etter revmatoid artritt. Sykdommen kan forekomme alene (primaer Sjögren) eller sekundaert til annen systemsykdom. Sjögrens syndrom kan defineres som en kronisk inflammatorisk og lymfoproliferativ sykdom med autoimmune trekk, karakterisert ved progressiv mononuklaer celleinfiltrasjon i eksokrine kjertler, saerlig spytt-og tårekjertler (autoimmun eksokrinopati). De viktigste kliniske aspektene er tørre øyne (keratokonjunctivitis sicca) og munntørrhet (xerostomia) 1 . KLINISKE FORHOLDPasientene har ofte en rekke andre symptomer relatert til tørrhet i slimhinner og hud, blant annet nasale skorper og neseblødning, heshet/taleproblemer, svelgbesvaer, halitose, tannproblemer, redusert lukt-og smakssans, residiverende hevelser i parotiskjertler, tørrhoste og dyspareuni. I tillegg er det vanlig med ledd-og muskelsmerter, utmattelse ("fatigue") og uspesifikke perifere nevrologiske symptomer. Mindre hyppig forekommende kan man se ikke-erosive artritter, Raynauds fenomen, hudvaskulitter, lymfadenopati, serositt, pulmonal fibrose, sentralnervøse symptomer og renal tubulaer acidose [1][2][3][4][5][6] . Komorbiditet i form av thyreoidealidelser er vanlig og kan forekomme hos opp mot en tredjedel av pasientene 7,8 .Behandling omfatter forskjellige former for lokalbehandlig for å lette tørrhetssymptomer. Pilokarpin peroralt kan stimulere til økt spyttproduksjon. Pasienter med artralgi eller mild artritt kan behandles med ikke-steroide ant...

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Long term course of tear gland function in patients with keratoconjunctivitis sicca and Sjogren's syndrome

Abstract: Aims-To assess the course of tear gland function of patients with keratoconjuncti-

Cited by 24 publications

References 15 publications

Tear Lipocalin and Lysozyme in Sjögren and Non-Sjogren Dry Eye

Tear Lipocalin and Lysozyme in Sjögren and Non-Sjogren Dry Eye

Tear proteomics in evaporative dry eye disease

Sjögrens syndrom

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