Our understanding of the frequency of large earthquakes at timescales longer than instrumental and historical records is based mostly on paleoseismic studies of fast-moving plate-boundary faults. Similar study of intraplate faults has been limited until now, because intraplate earthquake recurrence intervals are generally long (10s to 100s of thousands of years) relative to conventional paleoseismic records determined by trenching. Long-term variations in the earthquake recurrence intervals of intraplate faults therefore are poorly understood. Longer paleoseismic records for intraplate faults are required both to better quantify their earthquake recurrence intervals and to test competing models of earthquake frequency (e.g., time-dependent, time-independent, and clustered). We present the results of U-Th dating of calcite veins in the Loma Blanca normal fault zone, Rio Grande rift, New Mexico, United States, that constrain earthquake recurrence intervals over much of the past ∼550 ka-the longest direct record of seismic frequency documented for any fault to date. The 13 distinct seismic events delineated by this effort demonstrate that for >400 ka, the Loma Blanca fault produced periodic large earthquakes, consistent with a time-dependent model of earthquake recurrence. However, this time-dependent series was interrupted by a cluster of earthquakes at ∼430 ka. The carbon isotope composition of calcite formed during this seismic cluster records rapid degassing of CO 2 , suggesting an interval of anomalous fluid source. In concert with U-Th dates recording decreased recurrence intervals, we infer seismicity during this interval records faultvalve behavior. These data provide insight into the long-term seismic behavior of the Loma Blanca fault and, by inference, other intraplate faults.earthquake | fault | geochronology | seismic | hazard R ecent increases in the rate of seismicity associated with subsurface wastewater injection have generated substantial interest in the seismic cycles of intraplate faults (1-4). Unfortunately, increasing seismicity in the continental interior has outpaced our understanding of the processes that govern natural earthquake recurrence on these faults. The seismic cycles of plate boundary faults are much better known, although the exact nature of their earthquake recurrence distributions remains much debated (5, 6). At the heart of this debate lies a fundamental question: Are seismogenic faults ever controlled by a stress-renewal process that can be approximated by elastic rebound theory? The latter states that stress buildup will be accommodated elastically until shear stress on the fault reaches a threshold value that will allow failure.If seismogenic faults are governed by a renewal process, then elastic rebound theory predicts that earthquakes will be produced quasiperiodically (7) (i.e., occur at regular intervals and therefore be "time-dependent") with steady tectonic loading. However, an alternative view posits that spatial and temporal variations in fault strength and/or mechan...