Long-term effect of medium-chain trigly-ceride on hepatic enzymes catalyzing lipogenesis and cholesterogenesis in rats.

Takase, Sachiko; Morimoto, Ayami; Nakanishi, Masayoshi; Muto, Yasutoshi

doi:10.3177/jnsv.23.43

Cited by 49 publications

(11 citation statements)

References 17 publications

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“…High dietary levels of MCT have been shown to raise tissue levels of palmitic and oleic acid [13], a factor which may well explain this finding. Overall, there was a tendency for oleic acid to reach a specific levels inadipose tissue.…”

Section: Discussionmentioning

confidence: 56%

Influence of Dietary Fat on the Lipid Composition of Perirenal Adipose Tissue in Rats

et al. 1990

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The influence of dietary fat on the composition of perirenal adipose tissue was studied in Wistar rats fed three experimental semisynthetic, isocaloric diets containing different qualities of fat (olive oil, butter and medium chain triglycerides + corn oil). Under these experimental conditions, the saturation index reflects the percentage of fatty acids supplied by each diet; this index was highest in animals fed the diet containing butter and lowest in the group in which olive oil was the dietary fat source. The amount of linoleic acid (the major component of the diunsaturation index) supplied by the diet is directly paralleled by levels of this fatty acid in perirenal adipose tissue, whereas the monounsaturation index in adipose tissues, considered an indicator of the dietary supply of monounsaturated fatty acids in the rat, failed to show a clearly proportional relationship between intake and perirenal adipose tissue levels.

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Section: Discussionmentioning

confidence: 56%

Influence of Dietary Fat on the Lipid Composition of Perirenal Adipose Tissue in Rats

et al. 1990

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“…Why MLCT consumption does not affect serum cholesterol levels needs to be determined. One possible explanation is that the activity of 3-hydroxy-3-methylglutaryl-CoA, a key enzyme in cholesterol synthesis, is reduced after MLCT administration [32]. In addition, LDL receptor activity in mononuclear cells is higher with MLCT than trilaurin consumption [33].…”

Section: Discussionmentioning

confidence: 98%

Medium‐ and Long‐Chain Triacylglycerols Reduce Body Fat and Blood Triacylglycerols in Hypertriacylglycerolemic, Overweight but not Obese, Chinese Individuals

Zhang

Liu

Wang

et al. 2010

Lipids

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In contrast to the consumption of long-chain triacylglycerols (LCT), consumption of medium- and long-chain triacylglycerols (MLCT) reduces the body fat and blood triacylglycerols (TAG) level in hypertriacylglycerolemic Chinese individuals. These responses may be affected by BMI because of obesity-induced insulin resistance. We aimed to compare the effects of consuming MLCT or LCT on reducing body fat and blood TAG level in hypertriacylglycerolemic Chinese subjects with different ranges of BMI. Employing a double-blind, randomized and controlled protocol, 101 hypertriacylglycerolemic subjects (including 67 men and 34 women) were randomly allocated to ingest 25-30 g/day MLCT or LCT oil as the only cooking oil for 8 consecutive weeks. Anthropometric measurements of body weight, BMI, body fat, WC, HC, blood biochemical variables, and subcutaneous fat area and visceral fat area in the abdomen were measured at week 0 and 8. As compared to subjects with BMI 24-28 kg/m(2) in the LCT group, corresponding subjects in the MLCT group showed significantly greater decrease in body weight, BMI, body fat, WC, ratio of WC to HC, total fat area and subcutaneous fat area in the abdomen, as well as blood TAG and LDL-C levels at week 8. Based upon our results, consumption of MLCT oil may reduce body weight, body fat, and blood TAG and LDL-C levels in overweight hypertriacylglycerolemic Chinese subjects but may not induce these changes in normal or obese hypertriacylglycerolemic subjects.

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“…The slight cholesterol-lowering effect of MCT, identified by many researchers, could be accounted for by a decrease in the intestinal absorption of cholesterol and a slowing of its synthesis from acetylCoA in the liver (3,31,43). Furthermore, several authors have suggested that modest weight losses, as little as 10% of initial weight are sufficient to control common complications of obesity, including hypercholesterolemia (2).…”

Section: Discussionmentioning

confidence: 99%

Effects of medium-chain fatty acids on body composition and protien metabolism in overweight rats

Simón

Fernández‐Quintela

Portillo

et al. 2000

J. Physiol. Biochem.

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The lack of efficiency of classical treatments for obesity has led to propose alternative strategies. In order to obtain information about the effects of dietary fatty acid composition on body fat and protein metabolism, overweight female rats were fed on isoenergetic diets, using either medium-chain (MCT) or long-chain (LCT) triglycerides as a lipid source. After 23 days, the MCT group had mildly decreased body weight but greatly reduced adipose tissue depots. All fat depots were significantly diminished. MCT-fed rats showed a decrease in some hormones involved in energy balance, such as leptin and triiodothyronine. Feeding MCT resulted in improvements in nitrogen balance. Muscle protein content was similar in both treatments despite an increase in protein degradation in the MCT group. The present data clearly show that a diet with MCT as lipid fuel depresses weight gain and fat stores, relative to a standard LCT diet.

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Long-term effect of medium-chain trigly-ceride on hepatic enzymes catalyzing lipogenesis and cholesterogenesis in rats.

Cited by 49 publications

References 17 publications

Influence of Dietary Fat on the Lipid Composition of Perirenal Adipose Tissue in Rats

Influence of Dietary Fat on the Lipid Composition of Perirenal Adipose Tissue in Rats

Medium‐ and Long‐Chain Triacylglycerols Reduce Body Fat and Blood Triacylglycerols in Hypertriacylglycerolemic, Overweight but not Obese, Chinese Individuals

Effects of medium-chain fatty acids on body composition and protien metabolism in overweight rats

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