Long-term effects of ambient air pollutants to blood lipids and dyslipidemias in a Chinese rural population

Mao, Shuyuan; Chen, Gongbo; Liu, Feifei; Li, Na; Wang, Chongjian; Liu, Yisi; Liu, Suyang; Lu, Yuanan; Xiang, Hao; Lee, Hyewon; Li, Shanshan

doi:10.1016/j.envpol.2019.113403

Cited by 79 publications

(55 citation statements)

References 44 publications

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“…A randomized, double‐blind, cross‐sectional trial found that PM 2.5 exposure resulted in significant changes in serum metabolites, including hormones, glucose, amino acids, and lipids (Li et al, 2017). Further studies have shown that exposure to PM 2.5 can cause dyslipidemia, including increases in LDL particles (LDL‐P), lipoprotein‐cholesterol (LDL‐C), TG‐rich particle concentrations (TRLP), TC, and TG and a decrease in HDL‐C (Mao et al, 2020; McGuinn et al, 2019). The multiethnic cross‐sectional study (MESA) based on atherogenic air pollution found that the number of HDL particles decreased by 0.64 μmol/L (95% CI, −0.82 to 0.71) for every 5 μg/m 3 increase in PM 2.5 concentration.…”

Section: Underlying Mechanisms Of Pm25‐induced Asmentioning

confidence: 99%

Progress in research on effect of PM_2.5 on occurrence and development of atherosclerosis

Tian

Zhao

et al. 2020

J of Applied Toxicology

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Fine particulate matter ≤2.5 μm (PM2.5) air pollution is regarded as one of the prominent risk factors that contributes to morbidity and mortality globally, among which cardiovascular disease (CVD) has been strongly associated with PM2.5 exposure and is a leading cause of death. Atherosclerosis (AS), the common pathological basis of many CVDs, is a progressive syndrome characterized by the accumulation of lipids and fibrous plaque in the arteries. Recent epidemiological and toxicological studies suggest that PM2.5 may also contribute to the development of AS, even at levels below the current air quality standards. In this paper, the complete pathological process of atherosclerotic plaque from occurrence to rupture leading to CVD was elaborated. Then, the growing epidemiological evidence linking PM2.5 to AS in humans was reviewed and summarized. Furthermore, the potential mechanisms of PM2.5‐mediated AS were discussed, including oxidative stress, inflammation, endothelial dysfunction, abnormal lipid metabolism, disturbance of the autonomic nervous system, and abnormal coagulation function. This paper aimed to provide a comprehensive view of the effect of PM2.5 on the occurrence and development of AS for better prevention and mitigation of adverse health impacts due to PM2.5 air pollution.

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Section: Underlying Mechanisms Of Pm25‐induced Asmentioning

confidence: 99%

Progress in research on effect of PM_2.5 on occurrence and development of atherosclerosis

Tian

Zhao

et al. 2020

J of Applied Toxicology

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“…Our patient cohort also showed that circulating levels of TG were higher in people living in PM 2.5 heavily polluted regions than in those living in low polluted areas. According to the data from a cohort study of 39,057 individuals in Henan, China, ambient air pollutants were associated with blood lipid levels, and higher pollution linked to dyslipidaemia [55].…”

Section: Discussionmentioning

confidence: 99%

D-Limonene Inhibits the Occurrence and Progression of LUAD by Suppressing Lipid Metabolism Dysregulation Induced by PM2.5 Exposure

Zhu¹,

Li²,

Feng³

et al. 2021

Preprint

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Background: PM2.5 exposure is associated with lung adenocarcinoma (LUAD), but the mechanism is unclear. The lack of understanding impedes our effort on prevention. This study examined a possible mechanism of lung cancer caused by PM2.5 exposure, and aimed to find a potential intervention for people living in PM2.5 polluted regions.Methods: PM2.5 was collected near South-North elevated way in Shanghai city. Lung adenocarcinoma cells, pulmonary epithelial cell and mice were exposed to PM2.5 or D-limonene for 48h and two month separately. Cell morphology, abilities of invasion, migration and proliferation, pulmonary fibrosis level were assessed. Lipid metabolism changes were also studied in 11,564 lung cancer patients.Results: PM2.5 exposure induced accumulation of lipid droplets in LUAD cells which was accompanied by increased malignant cellular behaviors and disrupted lipid metabolism. PM2.5 exposure of LUAD led to cleaved N-SREBP1 translocation from the cytoplasm to nucleus, which upregulated the expression of FASN and ACACA. These changes increased lipid accumulation in LUAD. D-limonene, a natural monoterpene, was found to inhibit the changes in lipid metabolism through upregulating the expression of miR-195, a reported tumor suppressor that inhibited the expression of SREBP1, FASN and ACACA specifically induced by PM2.5 exposure. Same changes were also observed in normal lung epithelial cells and normal lung tissue from mice after PM2.5 exposure, and the changes were inhibited by D-limonene treatment. Furthermore, in a cohort of 11,564 lung cancer patients, significant lipid metabolism disorders were observed in high, compared to low, PM2.5 polluted areas, and a small human intervention trial showed that serum miR-195 was upregulated after oral intake of D-limonene.Conclusion: Our study reveals a potential intervention target for LUAD that is related to PM2.5 exposure-induced lipid metabolism disturbance and that D-limonene may inhibit the disruption through the upregulation of miR-195, which suggests a novel low-cost preventive intervention for people living in PM2.5 polluted regions.

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“…A randomized study of 24,845 participants selected from across China found a 10-μg/m 3 increase in PM1 and PM2.5 was associated with a 5% increase in odds for HTN (OR:1.05; 95% CI 1.01-1.10) (Yang et al, 2019). Another approach using data from the Henan Rural Cohort Study found each 1-μg/m 3 increment of PM2.5 was associated with increased TC and LDL-C, and decreased TG and HDL-C (Mao et al, 2019). The 33 Communities Chinese Health Study produced similar associations between particulates and blood lipids (Yang et al, 2018).…”

Section: Cardiometabolic Effects Of Trace Metalsmentioning

confidence: 99%

The Rise of ST-Elevation Myocardial Infarction in Women of Northeast China

Wang¹,

Newsome²

2021

Gerontology and Geriatric Medicine

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The women of China’s Liaoning province display some morbidities in ways that defy medical explanation. Women have higher rates of hypertension, hypercholesterolemia, and metabolic syndrome than men, an anomaly for all three conditions. Most of these patients also suffer from Type 2 Diabetes Mellitus (T2DM) while there was a negative association between being female and T2DM for the rest of China. Each of these conditions can exist independently, but the increase in both their rates and congruence is a recent phenomenon. Stranger still is that Liaoning women are now presenting in hospital emergency departments with ST-Elevation Myocardial Infarction (STEMI), while diabetics predominantly suffer more benign Non-STEMI (NSTEMI) events. Confounding factors in any attempt to study this phenomenon include trace metals like manganese that have been shown to reduce systolic blood pressure in Asian men and raise it in Asian women. Some of the phenomenon may also be associated with the gene for Apolipoprotein 5, but its recent nature suggests other factors besides lipid profiles. Trace metals in the air, water, and diet of Liaoning province, or any urban environment, could play a role.

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Long-term effects of ambient air pollutants to blood lipids and dyslipidemias in a Chinese rural population

Cited by 79 publications

References 44 publications

Progress in research on effect of PM_2.5 on occurrence and development of atherosclerosis

Progress in research on effect of PM_2.5 on occurrence and development of atherosclerosis

D-Limonene Inhibits the Occurrence and Progression of LUAD by Suppressing Lipid Metabolism Dysregulation Induced by PM2.5 Exposure

The Rise of ST-Elevation Myocardial Infarction in Women of Northeast China

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Long-term effects of ambient air pollutants to blood lipids and dyslipidemias in a Chinese rural population

Cited by 79 publications

References 44 publications

Progress in research on effect of PM2.5 on occurrence and development of atherosclerosis

Progress in research on effect of PM2.5 on occurrence and development of atherosclerosis

D-Limonene Inhibits the Occurrence and Progression of LUAD by Suppressing Lipid Metabolism Dysregulation Induced by PM2.5 Exposure

The Rise of ST-Elevation Myocardial Infarction in Women of Northeast China

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Progress in research on effect of PM_2.5 on occurrence and development of atherosclerosis

Progress in research on effect of PM_2.5 on occurrence and development of atherosclerosis