Long-Term Effects of Anterior Thalamic Nucleus Deep Brain Stimulation on Spatial Learning in the Pilocarpine Model of Temporal Lobe Epilepsy

Ferreira, Elenn Soares; Vieira, Laís Gabrielle; Moraes, Daniela Macêdo de; Amorim, Beatriz Oliveira; Malheiros, Jackeline Moraes; Hamani, Clement; Covolan, Luciene

doi:10.1111/ner.12688

Cited by 18 publications

(10 citation statements)

References 41 publications

(55 reference statements)

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“…This may be because animals in the aforementioned previous studies underwent ANT-DBS during the chronic phase, while in the present study, animals underwent ANT-DBS immediately after the successful induction of SE. In a recent study, the animals also underwent ANT-DBS during SE and the silent period [48]. In contrast to the present study, neuronal rescue was also observed 4 months after SE.…”

Section: Discussioncontrasting

confidence: 93%

The Role of Hippocampal Neurogenesis in ANT-DBS for LiCl-Pilocarpine-Induced Epileptic Rats

Tang¹,

He²,

Feng³

et al. 2020

Stereotact Funct Neurosurg

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Purpose: Abnormal neurogenesis in the hippocampus after status epilepticus (SE) has been suggested as a key pathogeny of temporal lobe epilepsy. This study aimed to investigate the effect of deep brain stimulation of the anterior thalamic nucleus (ANT-DBS) on hippocampal neurogenesis in LiCl-pilocarpine-induced epileptic rats and to analyze its relationship with postoperative spontaneous recurrent seizures (SRS) and anxiety. Method: SE was induced by a systemic LiCl-pilocarpine injection in adult male rats. Rats in the DBS group underwent ANT-DBS immediately after successful SE induction. SRS was only recorded during the chronic stage. An elevated plus maze was used to evaluate the level of anxiety in rats 7, 28, and 60 days after SE onset. After the elevated plus-maze experiment, rats were sacrificed under anesthesia in order to evaluate hippocampal neurogenesis. Doublecortin (DCX) was used as a marker for neurogenesis. Results: During the chronic stage, SRS in rats in the DBS group were significantly decreased. The level of anxiety was increased significantly in rats in the DBS group 28 days after SE, while no significant differences in anxiety levels were found 7 and 60 days after SE. The number of DCX-positive cells in the hippocampus was significantly increased 7 days after SE and was significantly decreased 60 days after SE in all rats in which SE was induced. However, the number of DCX-positive cells in the DBS group was significantly lower than that in the other groups 28 days after SE. Conclusions: ANT-DBS may suppress SRS and increase the postoperative anxiety of epileptic rats by influencing hippocampal neurogenesis.

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Section: Discussioncontrasting

confidence: 93%

The Role of Hippocampal Neurogenesis in ANT-DBS for LiCl-Pilocarpine-Induced Epileptic Rats

Tang¹,

He²,

Feng³

et al. 2020

Stereotact Funct Neurosurg

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“…The reduction of hippocampal ADK expression reported here is in line with a previously proposed role of adenosine as a potential candidate to underlie the neuroprotective, anti-inflammatory [29], and seizure suppressing roles of ANT-DBS in the pilocarpine model of temporal lobe epilepsy (TLE) [30]. The rationale behind that study was based on the well-characterized role of endogenous adenosine as seizure suppressor and seizure terminator [25,62].…”

Section: Discussionsupporting

confidence: 84%

“…ANT-DBS was paired with each PTZ-kindling injection, started 2 h prior to each PTZ injection and continued for 30 min after the injection. This stimulation schedule matched a previous study conducted by our group using pilocarpine to induce status epilepticus (SE) [30]. At the end of experiments, correct electrode placement was validated in all DBS animals (Fig.…”

Section: Surgical Procedures and Ant Stimulation Parametersmentioning

confidence: 83%

Deep brain stimulation of the anterior thalamus attenuates PTZ kindling with concomitant reduction of adenosine kinase expression in rats

et al. 2022

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“…Similar results were observed when DBS was applied to other brain targets (e.g., hippocampus) ( 159 ). Despite its seizure-modulating actions, AN DBS does not alter neo-Timm expression in the pilocarpine model of epilepsy ( 177 ).…”

Section: Alternative Epilepsy Treatments With or Without Effect On Momentioning

confidence: 99%

Is Mossy Fiber Sprouting a Potential Therapeutic Target for Epilepsy?

et al. 2018

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Mesial temporal lobe epilepsy (MTLE) caused by hippocampal sclerosis is one of the most frequent focal epilepsies in adults. It is characterized by focal seizures that begin in the hippocampus, sometimes spread to the insulo-perisylvian regions and may progress to secondary generalized seizures. Morphological alterations in hippocampal sclerosis are well defined. Among them, hippocampal sclerosis is characterized by prominent cell loss in the hilus and CA1, and abnormal mossy fiber sprouting (granular cell axons) into the dentate gyrus inner molecular layer. In this review, we highlight the role of mossy fiber sprouting in seizure generation and hippocampal excitability and discuss the response of alternative treatment strategies in terms of MFS and spontaneous recurrent seizures in models of TLE (temporal lobe epilepsy).

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Long-Term Effects of Anterior Thalamic Nucleus Deep Brain Stimulation on Spatial Learning in the Pilocarpine Model of Temporal Lobe Epilepsy

Cited by 18 publications

References 41 publications

The Role of Hippocampal Neurogenesis in ANT-DBS for LiCl-Pilocarpine-Induced Epileptic Rats

The Role of Hippocampal Neurogenesis in ANT-DBS for LiCl-Pilocarpine-Induced Epileptic Rats

Deep brain stimulation of the anterior thalamus attenuates PTZ kindling with concomitant reduction of adenosine kinase expression in rats

Is Mossy Fiber Sprouting a Potential Therapeutic Target for Epilepsy?

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