2020
DOI: 10.1016/j.fct.2019.110865
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Long-term effects of low doses of Chlorpyrifos exposure at the preweaning developmental stage: A locomotor, pharmacological, brain gene expression and gut microbiome analysis

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Cited by 38 publications
(16 citation statements)
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“…Interestingly, enhanced anxiety was observed in adult offspring to Mthfr deficiency dams ( Sadigurschi and Golan, 2018 ). GABA has also been implicated in the effects of exposure to CPF on anxiety, while perinatal CPF increased anxiety in female mice, but reduced anxiety in zebrafish larvae ( Braquenier et al, 2010 ; Venerosi et al, 2010 ; Richendrfer et al, 2012 ; Perez-Fernandez et al, 2020 ), although the underlying mechanism is unknown. The GABAergic pathway and parvalbumin interneurons undergo dramatic developmental maturation at the first postnatal week ( Rivera et al, 1999 ; Huang et al, 2007 ) that may affect USV development.…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, enhanced anxiety was observed in adult offspring to Mthfr deficiency dams ( Sadigurschi and Golan, 2018 ). GABA has also been implicated in the effects of exposure to CPF on anxiety, while perinatal CPF increased anxiety in female mice, but reduced anxiety in zebrafish larvae ( Braquenier et al, 2010 ; Venerosi et al, 2010 ; Richendrfer et al, 2012 ; Perez-Fernandez et al, 2020 ), although the underlying mechanism is unknown. The GABAergic pathway and parvalbumin interneurons undergo dramatic developmental maturation at the first postnatal week ( Rivera et al, 1999 ; Huang et al, 2007 ) that may affect USV development.…”
Section: Discussionmentioning
confidence: 99%
“…Sub-chronic and chronic exposure of mice to glyphosphates increased anxiety and depression-like behaviors and altered the gut microbiota composition, decreasing the Corynebacterium, Firmicutes, Bacteroidetes and Lactobacillus in particular [165]. Analysis of low dose Chlorpyrifos exposure at the late postnatal pre-weaning stage of rats indicated changes in neurotransmission parameters and induction of gut microbiota dysbiosis at both genus and species levels [167]. Given these connections, it is thus conceivable that pesticide-induced gut microbiota dysbiosis could play at least an indirect role in AD pathogenesis.…”
Section: Dysfunction Of the Brain-gut Axismentioning
confidence: 99%
“…Evidence for this notion is provided by, for example, a recent report using an AD-like pathology with amyloid and neurofibrillary tangles (ADLPAPT) transgenic mouse model of AD [162], whereby transplantation of fecal microbiota from wild-type mice into ADLPAPT mice ameliorated plaque and NFT formation, reduced glial activation, and alleviated cognitive impairment [163]. A number of reports have now indicated that a wide range of pesticides, such as the fungicide propamocarb [164], glyphosate herbicides [165], carbamate insecticide Aldicarb [166], and Chlorpyrifos [167,168] are all known to alter gut microbiota and cause varying degrees of dysbiosis. Exposure of propamocarb to mice at 3-300 mg/L through drinking water for a duration of 28 days changed the microbiota in the cecal and fecal contents at phylum or genus levels [164].…”
Section: Dysfunction Of the Brain-gut Axismentioning
confidence: 99%
“…It was observed that exposed mice gut microbiota showed an increment in Proteobacteria phylum and a decrement in Bacteroidetes phylum, suggesting that these phyla are mainly affected by CPF exposure [ 52 ]. Still, long-term exposure seems to amplify spontaneous vertical activity and female activity after acute stress in Wistar rats [ 53 ]. The host’s genetic profile can change the gut microbial response to CPF exposure.…”
Section: Organophosphate Pesticides (Opps)mentioning
confidence: 99%