Long-term effects of overfeeding during lactation on insulin secretion — the role of GLUT-2

Cunha, Alessandra Cordeiro de Souza Rodrigues; Pereira, Renata O.; Pereira, Mario José dos Santos; Soares, Vivian de Melo; Renovato-Martins, Mariana; Teixeira, Michelle Teixeira; Souza, Edison; Moura, Aníbal Sanchez

doi:10.1016/j.jnutbio.2008.05.002

Cited by 53 publications

(24 citation statements)

References 54 publications

(63 reference statements)

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“…Our findings also indicated that overfed females presented glucose intolerance, corroborating the findings reported by Plagemann et al, 5 Balonan, Sheng, 31 and Cunha et al, 32 who, when analyzing other maternal overfeeding models, observed that Table 2. Evaluation of organs weight, histometry, and sperm parameters in rats of the normal litter group (NL) compared with the small litter group (SL).…”

Section: Discussionsupporting

confidence: 92%

“…On the other hand, several studies have demonstrated that obesity in females is associated with metabolic alterations 5,31,32 as well as reproductive disorders, 33,34 reducing not only the quality of life of the animals, but also maternal health and that of their descendants, When analyzing females, overfed precociously significant increases in body weight and in food consumption are noted, corroborating the findings reported by Cunha et al, 32 who demonstrated an increase in milk consumption in Wistar females from small litter, inducing excess weight in their offspring. In addition, SL females also presented increased perigonadal fat when compared with NL females.…”

Section: Discussionmentioning

confidence: 99%

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Effect of postnatal overfeeding on the male and female Wistar rat reproductive parameters

Costa

Andreazzi

Bolotari

et al. 2019

J Dev Orig Health Dis

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Overweight/obesity has become a worldwide epidemic, and factors such as a sedentary lifestyle and inadequate eating habits directly contribute to the development of this condition. Studies indicate that rapid weight gain at critical development stages, such as the lactation period, is associated with the development of obesity, cardiovascular diseases, and diabetes in the long term. In addition to metabolic changes during adulthood, overweight/obesity may influence reproductive function of the population. In this context, the present study aimed to evaluate postnatal overfeeding effects on male and female Wistar rat reproductive parameters. Postnatal overfeeding was induced by applying the litter reduction method for both sexes. Forty animals were used, divided into four groups: two with normal litters (NL♂ and NL♀) and two with small litters (SL♂ and SL♀). The males were euthanized at 90 days of age, on the same date the females were mated. Females were also euthanized after the 20-day gestation. Metabolic and reproductive variables were analyzed. Regarding males, SL animals showed increased body weight, adiposity, and decreased relative weight of the seminal vesicle, prostate, and epididymis as well as changes in the ITT and OGTT glycemic tests. Concerning females, SL animals presented increased body weight, relative perigonadal fat weight, glucose intolerance as well as modify the vaginal opening and increased weight of female pup. The litter reduction method was efficient in leading to metabolic and reproductive alterations in male and female Wistar rat.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Effect of postnatal overfeeding on the male and female Wistar rat reproductive parameters

Costa

Andreazzi

Bolotari

et al. 2019

J Dev Orig Health Dis

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“…We observed in OF group at 7 months of age an impaired glucose tolerance and insulin resistance. Similar data have been reported in young OF mice at weaning 60 , and in adult OF rats 6 , 14 . Aging in humans and in animal studies has also been associated with the loss of insulin sensitivity 61 .…”

Section: Discussionsupporting

confidence: 89%

“…Notably, in humans, overnutrition during the perinatal period has been linked to obesity and the associated comorbidities. In rodents, reducing the litter size after birth decreases competition for milk during the suckling period and therefore induces over-nourishment in the postnatal period, which in turn leads to increased body weight and fat content at weaning 6 . Furthermore, transient postnatal overfeeding (OF) provokes metabolic (e.g., hyperphagia, overweight, insulin resistance, higher total and visceral fat mass, altered lipid profile) and cardiovascular (e.g., hypertension, cardiac dysfunction) disorders in adulthood, often associated with increased oxidative stress (OS) 7 – 15 .…”

Section: Introductionmentioning

confidence: 99%

Transient postnatal overfeeding causes liver stress-induced premature senescence in adult mice

Yzydorczyk

Chehade

et al. 2017

Sci Rep

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Unbalanced nutrition early in life is increasingly recognized as an important factor in the development of chronic, non-communicable diseases at adulthood, including metabolic diseases. We aimed to determine whether transient postnatal overfeeding (OF) leads to liver stress-induced premature senescence (SIPS) of hepatocytes in association with liver structure and hepatic function alterations. Litters sizes of male C57BL/6 mice were adjusted to 9 pups (normal feeding, NF) or reduced to 3 pups during the lactation period to induce transient postnatal OF. Compared to the NF group, seven-month-old adult mice transiently overfed during the postnatal period were overweight and developed glucose intolerance and insulin resistance. Their livers showed microsteatosis and fibrosis, while hepatic insulin signaling and glucose transporter protein expressions were altered. Increased hepatic oxidative stress (OS) was observed, with increased superoxide anion production, glucose-6-phosphate dehydrogenase protein expression, oxidative DNA damage and decreased levels of antioxidant defense markers, such as superoxide dismutase and catalase proteins. Hepatocyte senescence was characterized by increased p21WAF, p53, Acp53, p16INK4a and decreased pRb/Rb and Sirtuin-1 (SIRT-1) protein expression levels. Transient postnatal OF induces liver OS at adulthood, associated with hepatocyte SIPS and alterations in liver structure and hepatic functions, which could be mediated by a SIRT-1 deficiency.

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“…2 Due to its particular genetic plasticity, neonatal period is critical for the determination of adult phenotypical characteristics, which orients the premise of cardiometabolic programming by early overfeeding (EO) during lactation; this period is susceptible to epigenetic changes, impacting gene expression and influencing the subsequent changes of developing metabolic diseases. 3 The EO model is intrinsically connected to the developmental origins of health and disease concept, which over the years has accumulated evidence towards explaining the discrepancy observed in the actual prevalence of obesity and the estimated impacts of isolated changes to lifestyle, since the concept was introduced 30 years ago with the foundational papers put forth by Dr. David Barker. [4][5][6] It has also been observed that puberty is a critical risk period for nutritional disorders, such as anorexia and bulimia.…”

Section: Introductionmentioning

confidence: 99%

Long-term effects of early overfeeding and food restriction during puberty on cardiac remodeling in adult rats

Cavalet

Ribeiro

Rosa

et al. 2020

J Dev Orig Health Dis

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Nutritional disorders during the perinatal period cause cardiometabolic dysfunction, which is observable in the early overfeeding (EO) experimental model. Therefore, severe caloric restriction has the potential of affecting homeostasis through the same epigenetic mechanisms, and its effects need elucidation. This work aims to determine the impact of food restriction (FR) during puberty in early overfed obese and non-obese animals in adult life. Three days after delivery (PN3), Wistar rats were separated into two groups: normal litter (NL; 9 pups) and small litter (SL; 3 pups). At PN30, some offspring were subjected to FR (50%) until PN60, or maintained with free access to standard chow. NL and SL animals submitted to food restriction (NLFR and SLFR groups) were kept in recovery with free access to standard chow from PN60 until PN120. Body weight and food intake were monitored throughout the experimental period. At PN120 cardiovascular parameters were analyzed and the animals were euthanized for sample collection. SLNF and SLFR offspring were overweight and had increased adiposity. Differences in blood pressure were observed only between obese and non-obese animals. Obese and FR animals have cardiac remodeling showing cardiomyocyte hypertrophy and the presence of interstitial and perivascular fibrosis. FR animals also show increased expression of AT1 and AT2 receptors and of total ERK and p-ERK. The present study showed that EO leads to the obese phenotype and cardiovascular disruptions. Interestingly, we demonstrated that severe FR during puberty leads to cardiac remodeling.

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Long-term effects of overfeeding during lactation on insulin secretion — the role of GLUT-2

Cited by 53 publications

References 54 publications

Effect of postnatal overfeeding on the male and female Wistar rat reproductive parameters

Effect of postnatal overfeeding on the male and female Wistar rat reproductive parameters

Transient postnatal overfeeding causes liver stress-induced premature senescence in adult mice

Long-term effects of early overfeeding and food restriction during puberty on cardiac remodeling in adult rats

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