Long Term Effects of Toki-shakuyaku-san on Brain Dopamine and Nerve Growth Factor in Olfactory-Bulb-Lesioned Mice

Song, Qinghua; Toriizuka, Kazuo; Jin, Guang‐Zhu; Yabe, Takeshi; Cyong, Jong‐Chol

doi:10.1254/jjp.86.183

Cited by 22 publications

(17 citation statements)

References 26 publications

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“…DSS can make NGF contents increase at 1 and 2 weeks and within 3 weeks, the expression returns to baseline [46]. Administration of DSS could decrease ChAT activity significantly in the cerebral cortex and the DH of ovariectomized mice along with a decrease of NE contents [47].…”

Section: The Effect On the Neurotransmitter And The Central Nervous Smentioning

confidence: 97%

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Danggui-Shaoyao-San: New Hope for Alzheimer's Disease

Fu¹,

Wang²,

Wang³

et al. 2016

Aging and disease

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Danggui-Shaoyao-San (DSS), also called Toki-shakuyaku-san (TJ-23) or Dangguijakyaksan (DJS), is a well-known herbal formula (Angelica sinensis (Oliv.) Diels., Ligusticum chuanxiong Hort., Paeonia lactiflora pall., Poria cocos (Schw.) Wolf, Alisma orientalis (Sam.) Juzep., Atractylodes macrocephala Koidz.), which has been widely used in oriental countries for the treatment of various gynecological diseases. Recent studies show that DSS has an effect on free radical-mediated neurological diseases and exhibits anti-inflammatory and antioxidant activities and reduces cell apoptosis in the hippocampus. In addition, DSS mediates the modulation of central monoamine neurotransmitter systems and ameliorates dysfunction of the central cholinergic nervous system and scopolamine-induced decrease in ACh levels. DSS improves the function of the dopaminergic, adrenergic, and serotonergic nervous systems. Interestingly, DSS can alleviate cognitive dysfunction of Alzheimer's disease (AD) patients, suggesting that it is a useful therapeutic agent for AD. This paper reviews the mechanism of DSS for the treatment of AD.

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Section: The Effect On the Neurotransmitter And The Central Nervous Smentioning

confidence: 97%

“…prevents the reduction of dopamine (DA) metabolites, dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA) in olfactory-bulb-lesioned mice [46]. DSS has been shown to improve memory impairment and acetylcholine and norepinephrine in the cerebral cortex and hippocampus [47].…”

mentioning

confidence: 99%

Danggui-Shaoyao-San: New Hope for Alzheimer's Disease

Fu¹,

Wang²,

Wang³

et al. 2016

Aging and disease

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show abstract

“…It has been reported that TSS increases NGF (1), has an antioxidant action, and has a prophylactic effect against free radical-mediated neurological disease associated with aging (2,3). Recent pharmacological studies revealed that TSS differentially enhances release of T helper 1 cytokines from peripheral blood mononuclear cells but not from decidual mononuclear cells (4).…”

Section: Introductionmentioning

confidence: 99%

Determination of the Effectiveness of Components of the Herbal Medicine Toki-Shakuyaku-San and Fractions of Angelica acutiloba in Improving the Scopolamine-Induced Impairment of Rat’s Spatial Cognition in Eight-Armed Radial Maze Test

et al. 2004

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Abstract. The improving effects of various components of Toki-Shakuyaku-San (TSS) and fractions isolated from Angelica acutiloba Radix (Toki) on scopolamine-induced spatial memory impairment were investigated in eight-armed radial maze. The scopolamine-induced memory impairment was characterized by prominent increase of error choices in addition to decreased correct choices. Toki, Cnidium officinale Rhizoma (Senkyu), Poria cocos Hoelen (Bukuryo), Alisma orientale Rhizoma (Takusha), and Atractylodes lancea Rhizoma (Sojutsu) increased the correct choices, while only the Toki, Sojutsu, and Takusha decreased the error choices. No effect was produced by Paeonia lactiflora Radix (Shakuyaku). Investigation of effects of fractions isolated from Toki revealed that its activity mainly resided in the butanol layer and its contents of N-methyl-b-carboline-3-carboxamide and amines. Moreover, the alkaloid, internal and external solutions (containing poly-, di-, and monosaccharides) obtained by dialysis with Visking cellophane tubing also improved the memory. However, no improving properties were detected for methanol and hexanol layers, L-(-)-tryptophan, L-arginine, L-(-)-lysine, and choline chloride. The results showed that the TSS components could improve the reference and working memory impaired by scopolamine. The improving effect of TSS is produced greatly by the Toki component, the activity of which was greatly produced by the fraction extracted by butanol.

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“…A useful strategy of addressing this problem is to administer drugs that either enhance the action of endogenous neuritogenic substances such as NGF or increase the expression of these substances in the central nervous system (1). Oral administration of Tokishakuyaku-san, a Chinese traditional medicine, has been reported to increase NGF content in olfactory-bulblesioned mice (2). Several synthetic compounds (3 -5) and natural products (6 -8) have been shown to enhance the action of NGF in neurite outgrowth from PC12 cells.…”

mentioning

confidence: 99%

Nardosinone Enhances Nerve Growth Factor-Induced Neurite Outgrowth in a Mitogen-Activated Protein Kinase- and Protein Kinase C-Dependent Manner in PC12D Cells

Yamakuni

Matsunaga

et al. 2003

J Pharmacol Sci

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Abstract. The mechanism to enhance nerve growth factor (NGF, 2 ng / ml)-induced neurite outgrowth from PC12D cells by nardosinone isolated from Nardostachys chinensis was examined. It was shown that the potentiation of the NGF-induced neurite outgrowth by nardosinone was mitogen-activated protein (MAP) kinase-dependent, but was not accompanied by stimulation of NGF-induced increase in MAP kinase phosphorylation. Furthermore, this augmentation of NGF-induced neurite outgrowth was abolished by GF109203X, a protein kinase C (PKC) inhibitor. These results suggest that the enhancement of NGF-induced neurite outgrowth from PC12D cells by nardosinone involves activation of a down-stream step of the MAP kinase-dependent cascade of NGF coupled with PKC.

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Long Term Effects of Toki-shakuyaku-san on Brain Dopamine and Nerve Growth Factor in Olfactory-Bulb-Lesioned Mice

Cited by 22 publications

References 26 publications

Danggui-Shaoyao-San: New Hope for Alzheimer's Disease

Danggui-Shaoyao-San: New Hope for Alzheimer's Disease

Determination of the Effectiveness of Components of the Herbal Medicine Toki-Shakuyaku-San and Fractions of Angelica acutiloba in Improving the Scopolamine-Induced Impairment of Rat’s Spatial Cognition in Eight-Armed Radial Maze Test

Nardosinone Enhances Nerve Growth Factor-Induced Neurite Outgrowth in a Mitogen-Activated Protein Kinase- and Protein Kinase C-Dependent Manner in PC12D Cells

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