Long-term evaluation of temporomandibular disorders in association with cytokine and autoantibody status in young women

Son, Chunghwan; Park, Yoon Kyung; Park, Ji Woon

doi:10.1016/j.cyto.2021.155551

Cited by 11 publications

(17 citation statements)

References 58 publications

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“…For example, local injection of cytokines [ 30 ], glutamate [ [35] , [36] , [37] , [38] ], serotonin [ 39 ], acid saline [ 40 ] and nerve growth factor [ 41 , 42 ] can cause pain and hyperalgesia in the deep craniofacial tissues. These results are consistent with the findings that TMD patients increase experimentally-induced pain sensitivity in the facial areas, in which the level of inflammatory mediators is elevated [ 24 , [27] , [28] , [29] , [30] , [31] , [32] , [33] , 43 , 44 ].…”

Section: Neural Mechanisms For Pain In the Deep Craniofacial Tissues In Humansupporting

confidence: 92%

“…IL-1 beta has been reported to play critical roles on the development and progression of TMD pain [ 22 , 24 ]. IL-2, -8 and -13 in the blood serum also indicate significant effects on generalized pain in TMD patients [ 28 ]. Besides cytokines, several mediators including prostaglandin E2, bradykinin and serotonin (5HT) are detected in the synovial fluid of TMJ in the TMD patients with internal derangements and osteoarthritis of TMJ, however, no correlation is found between each mediator and pain [ 29 ].…”

Section: Neural Mechanisms For Pain In the Deep Craniofacial Tissues In Humanmentioning

confidence: 99%

See 1 more Smart Citation

Preclinical models of deep craniofacial nociception and temporomandibular disorder pain

Okamoto

Hasegawa

Piriyaprasath

et al. 2021

Japanese Dental Science Review

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Section: Neural Mechanisms For Pain In the Deep Craniofacial Tissues In Humansupporting

confidence: 92%

Section: Neural Mechanisms For Pain In the Deep Craniofacial Tissues In Humanmentioning

confidence: 99%

Preclinical models of deep craniofacial nociception and temporomandibular disorder pain

Okamoto

Hasegawa

Piriyaprasath

et al. 2021

Japanese Dental Science Review

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“…The accumulating evidence supports the intimate relationship between physical activity, sleep quality, and systemic inflammation which are all factors known to influence TMD symptoms in previous literature [71][72][73][74]. Through this prospective study based on objective physical activity measurements in a well-defined patient group of TMD, the resulting data will be able to support the establishment of a clinical guideline related to physical activity recommendations and the diagnostic value of such measurements in TMD prognosis.…”

Section: Discussionsupporting

confidence: 71%

Does physical activity level have an impact on long-term treatment response in temporomandibular disorders: protocol for a prospective study

Chun

Park

2022

BMC Oral Health

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Background Temporomandibular disorders (TMD) is a disease characterized by pain and dysfunction of the masticatory muscles and temporomandibular joint. Many factors have been found to be related to the disease however, the underlying mechanism is yet to be fully elucidated. Physical activity is widely known to modulate pain intensity in various pain disorders. However, literature suggesting the association between physical activity and signs and symptoms of TMD are limited. Methods and design The “Physical Activity in TMD (PAT)” is a prospective study on TMD patients that aims to determine how daily physical activity and sleep duration affect long-term TMD prognosis following conventional treatment. To analyze such effects, objective data on daily physical activity levels will be collected along with clinical indices including mouth opening ranges and masticatory muscle palpation responses from adult Koreans diagnosed with TMD following standardized diagnostic procedures. Well-known comorbidities of TMD will be extensively evaluated based on validated structured questionnaires on sleep quality, fatigue level, widespread pain, psychological status including depression and anxiety, autonomic symptoms, and health-related quality of life. The collected data will be analyzed according to TMD pain severity and physical activity level, and correlations among physical activity indices and long-term TMD prognosis will be investigated. Discussion In this longitudinal prospective study of adult Koreans diagnosed with TMD following standardized diagnostic procedures, primary outcomes include physical activity levels and long-term TMD clinical outcomes and secondary outcomes include disability from pain and related comorbidity levels. Results and analysis are ongoing. The results of this study will provide reliable data for future research and establish clinical guidelines that will allow cause-related, patient-tailored personalized medicine for TMD. Trial registration: Clinical Research Information Service (Registration number: KCT0007107). Registered March 22 2022 https://cris.nih.go.kr/cris/search/detailSearch.do?search_lang=E&focus=reset_12&search_page=M&pageSize=10&page=undefined&seq=21420&status=5&seq_group=21420.

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“…Results of this study showed that bone morphogenetic protein (BMP) type 2 and 4, epidermal growth factor (EGF), eotaxin, granulocyte-colony stimulating factor (G-CSF), IL-1β, IL-7, IL-8, IL-10, macrophage inflammatory protein (MIP) 1β, TNF-α and TNF-β had significantly higher concentrations in patients with disc displacement without reduction. In 2021, Son et al [ 167 ] investigated the relationship between long-term clinical characteristics and different cytokine and autoimmunity levels in young female TMD patients according to pain disability. The subjects included in the study were classified in high and low disability groups, according to the Graded Chronic Pain Scale (GCPS).…”

Section: Oxygen-ozone and Temporomandibular Disordersmentioning

confidence: 99%

Oxygen-Ozone Therapy for Reducing Pro-Inflammatory Cytokines Serum Levels in Musculoskeletal and Temporomandibular Disorders: A Comprehensive Review

Sire

Marotta

Ferrillo

et al. 2022

IJMS

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To date, the application of oxygen-ozone (O2O3) therapy has significantly increased in the common clinical practice in several pathological conditions. However, beyond the favorable clinical effects, the biochemical effects of O2O3 are still far from being understood. This comprehensive review aimed at investigating the state of the art about the effects of O2O3 therapy on pro-inflammatory cytokines serum levels as a modulator of oxidative stress in patients with musculoskeletal and temporomandibular disorders (TMD). The efficacy of O2O3 therapy could be related to the moderate oxidative stress modulation produced by the interaction of ozone with biological components. More in detail, O2O3 therapy is widely used as an adjuvant therapeutic option in several pathological conditions characterized by chronic inflammatory processes and immune overactivation. In this context, most musculoskeletal and temporomandibular disorders (TMD) share these two pathophysiological processes. Despite the paucity of in vivo studies, this comprehensive review suggests that O2O3 therapy might reduce serum levels of interleukin 6 in patients with TMD, low back pain, knee osteoarthritis and rheumatic diseases with a concrete and measurable interaction with the inflammatory pathway. However, to date, further studies are needed to clarify the effects of this promising therapy on inflammatory mediators and their clinical implications.

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Long-term evaluation of temporomandibular disorders in association with cytokine and autoantibody status in young women

Cited by 11 publications

References 58 publications

Preclinical models of deep craniofacial nociception and temporomandibular disorder pain

Preclinical models of deep craniofacial nociception and temporomandibular disorder pain

Does physical activity level have an impact on long-term treatment response in temporomandibular disorders: protocol for a prospective study

Oxygen-Ozone Therapy for Reducing Pro-Inflammatory Cytokines Serum Levels in Musculoskeletal and Temporomandibular Disorders: A Comprehensive Review

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