Long‐term experience with low‐dose interferon‐α and PUVA in the management of early mycosis fungoides

Abstract

Complete remission (CR) was achieved in 84% and an overall response rate in 98% of cases: six-month CR was associated with a non-confluent skin infiltrate at histology (P = 0.044) and 14-month CR with high epidermal CD1a+ dendritic-cell density (P = 0.030). The combination protocol was successfully tolerated and the most common reason of 'failure' was related to relapse and not to toxicity. Sustained remissions were achieved in 20% of patients. High CD8+ lymphoid T-cell density was associated with a lower relapse rate (P = 0.002). We think that our combination therapy can be considered an alternative approach compared with other modalities. Good immunological host surveillance in the skin lesions seems to be an optimal basis for the therapeutic success.

Kutane Lymphome

“…Anfang der 90er-Jahre wurde eine prospektiv angelegte, randomisierte [24]. Basierend auf diesen Daten, gehört die Kombinationstherapie Interferon plus PUVA zu den effektivsten, die für die frühen Stadien des CTCL zur Verfügung stehen [19].…”

Primary Cutaneous Lymphomas and Interferon Treatment

“…In this trial disease free survival projected to 48 months was 75% [53]. Subsequently in a multicentric prospective Phase II clinical study on 89 patients with early-stage IA to IIA MF treated for 14 months with low-dose IFN α-2b (6-18 MU/wk) and PUVA, they have been reported that CR was achieved in 84% and an overall response rate in 98% of cases [54]. The treatment was well tolerated and treatment failure due to toxicity was not frequent in the patients.…”

Utility of FDG-PET for Staging in a Case of Mycosis Fungoides

“…Mucosal involvement is uncommon and occurs usually in the form of oral ulcers and gingival hyperplasia whereas genitalia are rarely affected [1] . Among the few cases of WG with…”

“…Treatment of MF also varies according to stage of disease. Early-stage MF is highly responsive to topical treatments such as topical chemotherapy, ultraviolet irradiation (psoralen + UVA) and immunomodulatory agents such as interferon and retinoids [1] . However, systemic disease, which requires more aggressive and potentially more toxic therapy such as systemic chemotherapy or total-skin electron beam therapy, may be clinically silent and therefore potentially missed [2] .…”

“…Fluoro-2-deoxy-D -glucose positron emission tomography ؒ Mycosis fungoides, staging ؒ Cutaneous T cell lymphoma Mycosis fungoides (MF) is the most common type of cutaneous T cell lymphoma [1] . It is a type of non-Hodgkin's lymphoma that is defined by clonal proliferation of skin-homing malignant T lymphocytes [2] .…”