Long-term experience with sodium chondroitin sulfate in patients with painful bladder syndrome

Pilot Study of Cystochon® (Cranberry Extract, Chondroitin Sulfate, and Hyaluronic Acid Complex) in Interstitial Cystitis/Bladder Pain Syndrome

“…Chondroitin sulfate is a major component of the GAG layer and is effective in improving pain and urinary frequency when intravesical instillation is performed in IC/BPS [2][3][4].…”

“…Although they have been deemed ineffective for treating urinary tract infections (UTIs), there is evidence suggesting that cranberry juice may reduce the number of symptomatic UTIs [1]. In addition, the intravesical instillation of hyaluronic acid and chondroitin sulfate is widely used, which relieves pain by replenishing the bladder mucosal glycosaminoglycan (GAG) layer damaged by inflammation [2][3][4]. This treatment reduces pain and protects the bladder wall from external irritants, such as urine and waste products.…”