Long-term exposure to ambient air pollution attenuated the association of physical activity with metabolic syndrome in rural Chinese adults: A cross-sectional study

Yang

et al. 2020

BMC Public Health

Self Cite

Background The relationship of spicy food intake with hyperuricemia remains unknown. The objective of this study was to examine the association between spicy food intake and hyperuricemia, and whether this association was mediated by body mass index (BMI) in Chinese rural population. Methods 38, 027 adults aged 18–79 years were recruited from the Henan Rural Cohort Study. Information on spicy food intake was obtained using a validated questionnaire survey. Multivariable logistic regression model was used to estimate the association between spicy food intake and hyperuricemia, multiple linear regression model was performed to estimate the relationships between spicy food intake, BMI and serum urate level. BMI was used as a mediator to evaluate the mediation effect. Results After adjusting for potential confounders, compared with no spicy food flavor, the odds ratio (OR) and 95% confidence interval (CI) of mild, middle, and heavy flavor for hyperuricemia were 1.09 (1.00–1.19), 1.10 (0.97–1.24), and 1.21 (1.10–1.46), respectively (Ptrend = 0.017). Similarly, compared with those without intake in spicy food, the multivariable adjusted OR (95% CI) of 1-2 days/week, 3–5 days/week, and 6–7 days/week were 1.15 (1.01–1.31), 1.14 (1.01–1.30) and 1.15 (1.05–1.26), respectively (Ptrend = 0.007). However, when we further controlling for BMI, the associations were substantially attenuated. Furthermore, mediation analysis showed that BMI play a full mediating role in the relationship of spicy food intake with hyperuricemia. Conclusion Spicy food flavor and intake frequency are positively related with hyperuricemia in Chinese rural population. BMI may play a full mediating role in the relationship. Trial registration The Henan Rural Cohort Study registered at Chinese Clinical Trial Register (Registration number: ChiCTR-OOC-15006699). Date of registration: 2015-07-06.

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Mediation effect of body mass index on the association between spicy food intake and hyperuricemia in rural Chinese adults: the Henan rural cohort study

Yang

et al. 2020

BMC Public Health

Self Cite

“…The analyses are based on data from the Henan Rural Cohort Study, which was a prospective study of chronic non-communicable diseases, the cohort pro le and study population has been described in elsewhere [18,19]. In brie y, the study was conducted in Yuzhou, Xinxiang, Tongxu, Yima and Suiping county of Henan Province, China from July 2015 to September 2017.…”

Section: Study Populationmentioning

confidence: 99%

“…PA and ST levels were assessed by using the International Physical Activity Questionnaire (IPAQ) [20]. As the details have been described previously [16,19], PA-metabolic equivalent (MET) was calculated by using MET coe cient of activity × duration (hour per time) × frequency (times per week) [19]. Therefore, according to the categories of PA, each category of vigorous activity, moderate activity and walking was calculated with the corresponding MET values of 8, 4, and 3.3 respectively.…”

Section: De Nitions Of Exposurementioning

confidence: 99%

Independent and interactive effect of sitting time and physical activity on prevalence of hyperuricemia: the Henan Rural Cohort Study

Zhang

et al. 2020

Preprint

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Abstract BackgroundThere are few studies on the hyperuricemia (HUA) and moderate to vigorous intensity physical activity (PA) and also hardly regarding sitting time (ST). The purpose of this study was to examine the independent and interactive association of PA and ST with HUA.MethodsA cross-sectional analysis was performed on 38,855 participants (aged 18-79) enrolled from the Henan Rural Cohort Study at baseline (2015 to 2017). PA and ST levels were assessed by using the International Physical Activity Questionnaire (IPAQ). HUA was defined as a serum uric acid level of >7.0 mg/dL for males and >6.0 mg/dL for females. Multivariable logistic regression and linear regression models were applied to examine the independent association between PA or ST and HUA and serum uric acid level. Interaction plots were used to visualize the interaction effects of PA and ST on HUA.ResultsPA level was inversely related with serum uric acid level (β: -0.09, 95% confidence interval (CI): -0.16, -0.02), but ST was positively related with uric acid level (β: 2.04, 95% CI:1.82, 2.26). Metabolic equivalent (MET-hour/day) was associated with decreased prevalence of HUA (odds ratio (OR): 0.98, 95% CI: 0.96, 0.99), while per hour increased for ST was associated with increased HUA (OR:1.05, 95% CI: 1.04, 1.06). The interaction of PA and ST was significant (P<0.001).ConclusionExposure to higher ST was independently related to increased prevalence of HUA, while vigorous PA with a decreased HUA prevalence. Meanwhile, higher daily ST might attenuate the protective effect of PA on HUA.Clinical Trial RegistrationThe Henan Rural Cohort Study has been registered at Chinese Clinical Trial Register (Registration number: ChiCTR-OOC-15006699). http://www.chictr.org.cn/showproj.aspx?proj=11375

“…The Henan Rural Cohort Study was conducted in 5 rural regions (Yuzhou , Suiping, Xinxiang county, Tongxu , and Yima county) of Henan province in China from July 2015 to September 2017. Detailed information on study design and eligibility criteria has been reported elsewhere [23,24]. A total of 39,259 participants aged 18-79 years old were recruited to complete the questionnaire and physical measurements.…”

Section: Study Populationmentioning

confidence: 99%

Mediation effect of body mass index on the association between spicy food intake and hyperuricemia in rural Chinese adults: the Henan Rural Cohort Study

Yang

et al. 2020

Preprint

Self Cite

Background: The relationship of spicy food intake with hyperuricemia remains unknow. The purpose of this study was to examine the association between spicy food intake and hyperuricemia, and whether this association was mediated by body mass index (BMI) in Chinese rural population.Methods: A total of 38, 027 adults, aged 18–79 years, were from the Henan Rural Cohort Study. Information on spicy food intake was obtained using a validated questionnaire survey. Multivariable logistic regression model was used to estimate the association between spicy food intake and hyperuricemia, multiple linear regression model was performed to estimate the relationships between spicy food intake, BMI and serum urate level. BMI was used as a mediator to estimate the mediation effect. Results: After adjusting for potential confounders, compared with no spicy food flavor, the odds ratio (OR) and 95% confidence interval (CI) of mild, middle, and heavy flavor for hyperuricemia was 1.09 (1.00-1.19), 1.10 (0.97-1.24), and 1.21 (1.10-1.46), respectively (Ptrend=0.017). Similarly, compared with no spicy food intake, the adjusted OR (95% CI) of 1 or 2days/week, 3-5 days/week, and 6 or 7 days/week were 1.15 (1.01-1.31), 1.14 (1.01-1.30) and 1.15 (1.05-1.26), respectively (Ptrend=0.007). Associations were substantially attenuated after additional control for BMI. Furthermore, mediation analysis showed that BMI play a full mediating role in the relationship between spicy food intake and hyperuricemia.Conclusion: Spicy food flavor and intake frequency is positively related with hyperuricemia in Chinese rural population. BMI may play a full mediating role in the relationship.