Long term exposure to organophosphorus pesticides and lipid metabolism in the rat

Critical Evaluation of Chlorpyrifos’ Breast Cancer Risk

“…This study cannot be regarded as a cancer bioassay since the animals were fed only one dose, for a relatively short period of time and histopathological evaluation of tissues was not performed (Buchet et al, 1977).…”

“…However, all these studies had many limitations that do not permit an evaluation of the carcinogenic potential of chlorpyrifos. The studies in rats were either limited by small numbers and low survival rates (McCollister et al, 1974), or by the inappropriate use of only one dose and short duration (Buchet et al, 1977). Sufficient details were not available for a critical evaluation of the unpublished studies in mice and rats.…”