Long-term exposure to traffic-related air pollution and stroke: A systematic review and meta-analysis

Haddad, P.; Joss, Meltem Kutlar; Weuve, Jennifer; Vienneau, Danielle; Atkinson, Richard; Brook, Jeffrey R.; Chang, Howard H.; Forastiére, Francesco; Hoek, Gerard; Kappeler, Ron; Lurmann, Fred; Sagiv, S.K.; Samoli, Evangelia; Smargiassi, Audrey; Szpiro, A.A.; Patton, Allison P.; Boogaard, Hanna; Hoffmann, Barbara

doi:10.1016/j.ijheh.2022.114079

Cited by 18 publications

(3 citation statements)

References 55 publications

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“…The inconsistency may be attributable to the agents in the traffic sources. In our study, the traffic source is mostly consistent of Cu, Fe, EC, and Ca, whereas other studies use nitrogen dioxide and PM 2.5 as the main agents for traffic-related toxicity [ 102 – 104 ].…”

Section: Discussionmentioning

confidence: 82%

Long-term exposure to ambient fine particulate components and leukocyte epigenome-wide DNA Methylation in older men: the Normative Aging Study

Wang

Amini

et al. 2023

Environ Health

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Background Epigenome-wide association studies of ambient fine particulate matter (PM2.5) have been reported. However, few have examined PM2.5 components (PMCs) and sources or included repeated measures. The lack of high-resolution exposure measurements is the key limitation. We hypothesized that significant changes in DNA methylation might vary by PMCs and the sources. Methods We predicted the annual average of 14 PMCs using novel high-resolution exposure models across the contiguous U.S., between 2000–2018. The resolution was 50 m × 50 m in the Greater Boston Area. We also identified PM2.5 sources using positive matrix factorization. We repeatedly collected blood samples and measured leukocyte DNAm with the Illumina HumanMethylation450K BeadChip in the Normative Aging Study. We then used median regression with subject-specific intercepts to estimate the associations between long-term (one-year) exposure to PMCs / PM2.5 sources and DNA methylation at individual cytosine-phosphate-guanine CpG sites. Significant probes were identified by the number of independent degrees of freedom approach, using the number of principal components explaining > 95% of the variation of the DNA methylation data. We also performed regional and pathway analyses to identify significant regions and pathways. Results We included 669 men with 1,178 visits between 2000–2013. The subjects had a mean age of 75 years. The identified probes, regions, and pathways varied by PMCs and their sources. For example, iron was associated with 6 probes and 6 regions, whereas nitrate was associated with 15 probes and 3 regions. The identified pathways from biomass burning, coal burning, and heavy fuel oil combustion sources were associated with cancer, inflammation, and cardiovascular diseases, whereas there were no pathways associated with all traffic. Conclusions Our findings showed that the effects of PM2.5 on DNAm varied by its PMCs and sources.

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Section: Discussionmentioning

confidence: 82%

Long-term exposure to ambient fine particulate components and leukocyte epigenome-wide DNA Methylation in older men: the Normative Aging Study

Wang

Amini

et al. 2023

Environ Health

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“…We adopted the Navigation Guide quality of evidence tool, Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) for the evaluation of the quality of evidence across studies, following previous studies (Lam et al, 2021;Cao et al, 2023;Haddad et al, 2023). The quality of evidence was categorized into four levels: high, moderate, low, and very low.…”

Section: Evaluation Of Quality Of Evidence Assessmentmentioning

confidence: 99%

The economics of nature’s healing touch: A systematic review and conceptual framework of green space, pharmaceutical prescriptions, and healthcare expenditure associations

Patwary,

Bardhan,

Browning

et al. 2023

Preprint

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Green spaces play a crucial role in promoting sustainable and healthy lives. Recent evidence shows that green space also may reduce the need for healthcare, prescription medications, and associated costs. This systematic review provides the first comprehensive assessment of the available literature examining green space exposure and its associations with healthcare prescriptions and expenditures. We applied Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines to search MEDLINE, Scopus, and Web of Science for observational studies published in English through May 6, 2023. A quality assessment of the included studies was conducted using the Office of Health Assessment and Translation (OHAT) tool, and the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) assessment was used to evaluate the overall quality of evidence. Our search retrieved 26 studies that met the inclusion criteria and were included in our review. Among these, 20 studies (77% of the total) showed beneficial associations of green space exposure with healthcare prescriptions or expenditures. However, most studies had risks of bias, and the overall strength of evidence for both outcomes was limited. Based on our findings and related bodies of literature, we present a conceptual framework to explain the possible associations and complex mechanisms underlying green space and healthcare outcomes. The framework differs from existing green space and health models by including upstream factors related to healthcare access (i.e., rurality and socioeconomic status), which may flip the direction of associations. Additional research with lower risks of bias is necessary to validate this framework and better understand the potential for green space to reduce healthcare prescriptions and expenditures.

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“…We applied the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) tool to classify the overall quality of evidence (Cao et al, 2023;Haddad et al, 2023;Lam et al, 2021). According to the GRADE, the quality of evidence was classified into four categories: "high," "moderate," "low," and "very low."…”

Section: Overall Quality Of Evidence Assessmentmentioning

confidence: 99%

Impact of Green Space and Built Environment on Metabolic Syndrome: A Systematic Review with Meta-Analysis

Patwary,

Sakhvidi,

Ashraf

et al. 2023

Preprint

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Metabolic Syndrome presents a significant public health challenge associated with an increased risk of noncommunicable diseases such as cardiovascular conditions. Evidence shows that green spaces and the built environment may influence metabolic syndrome. We conducted a systematic review and meta-analysis of observational studies published through August 30, 2023, examining the association of green space and built environment with metabolic syndrome. A quality assessment of the included studies was conducted using the Office of Health Assessment and Translation (OHAT) tool. The Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) assessment was used to evaluate the overall quality of evidence. Our search retrieved 18 studies that met the inclusion criteria and were included in our review. Most were from China (n=5) and the U.S. (n=5), and most used a cross-sectional study design (n=8). Nine studies (50%) reported only green space exposures, seven (39%) reported only built environment exposures, and two (11%) reported both built environment and green space exposures. Studies reported diverse definitions of green space and the built environment, such as availability, accessibility, and quality, particularly around participants’ homes. The outcomes focused on metabolic syndrome; however, studies applied different definitions of metabolic syndrome. Meta-analysis results showed that an increase in normalized difference vegetation index (NDVI) within a 500-m buffer was associated with a lower risk of metabolic syndrome (odds ratio [OR]=0.90, 95%CI=0.87−0.93, I2=22.3%, n=4). A substantial number of studies detected bias for exposure classification and residual confounding. Overall, the extant literature shows a ‘limited’ strength of evidence for green space protecting against metabolic syndrome and an 'inadequate' strength of evidence for the built environment associated with metabolic syndrome. Studies with more robust study designs, better controlled confounding factors, and stronger exposure measures are needed to understand better what types of green spaces and built environment features influence metabolic syndrome.

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Long-term exposure to traffic-related air pollution and stroke: A systematic review and meta-analysis

Cited by 18 publications

References 55 publications

Long-term exposure to ambient fine particulate components and leukocyte epigenome-wide DNA Methylation in older men: the Normative Aging Study

Long-term exposure to ambient fine particulate components and leukocyte epigenome-wide DNA Methylation in older men: the Normative Aging Study

The economics of nature’s healing touch: A systematic review and conceptual framework of green space, pharmaceutical prescriptions, and healthcare expenditure associations

Impact of Green Space and Built Environment on Metabolic Syndrome: A Systematic Review with Meta-Analysis

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