Long term follow-up of dermofasciectomy for Dupuytren's contracture

Brotherston, T. M.; Balakrishnan, Chenicheri; Milner, R.H.; Brown, H.G.

doi:10.1016/0007-1226(94)90075-2

Cited by 51 publications

(24 citation statements)

References 9 publications

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“…Previous reports, however, have shown 100% reduction in recurrence more than 8 years after dermofasciectomy. 22 It has been postulated that inadequate removal of DD tissue at the time of surgery is a cause of recurrence; this, however, does not explain the progress of a microscopic focus developing into recurrent macroscopic nodules. 3 It has been suggested that if DD tissue is excised incompletely, then myofibroblasts may be further induced, causing local hyperplasia 23 of the remaining tissue and presenting as recurrent DD.…”

Section: Discussionmentioning

confidence: 99%

Dupuytren’s Diathesis Revisited: Evaluation of Prognostic Indicators for Risk of Disease Recurrence

Hindocha

Stanley²,

Watson³

et al. 2006

The Journal of Hand Surgery

158

105

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Section: Discussionmentioning

confidence: 99%

Dupuytren’s Diathesis Revisited: Evaluation of Prognostic Indicators for Risk of Disease Recurrence

Hindocha

Stanley²,

Watson³

et al. 2006

The Journal of Hand Surgery

158

105

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“…Clinically, full-thickness skin grafts (in which the dermis is included) have been shown to attenuate recurrence of DD in some studies [7,[74][75][76], implying that local environment of the DD cord left behind after resection may contain factors that promote disease recurrence. Our in vitro data suggest that PF fibroblasts, derived from the palmar fascia immediately adjacent to DD cord, are sensitive to periostin-induced proliferation.…”

Section: Discussionmentioning

confidence: 99%

Periostin differentially induces proliferation, contraction and apoptosis of primary Dupuytren's disease and adjacent palmar fascia cells

Vi¹,

Feng²,

Zhu³

et al. 2009

Experimental Cell Research

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Dupuytren's disease, (DD), is a fibroproliferative condition of the palmar fascia in the hand, typically resulting in permanent contracture of one or more fingers. This fibromatosis is similar to scarring and other fibroses in displaying excess collagen secretion and contractile myofibroblast differentiation. In this report we expand on previous data demonstrating that POSTN mRNA, which encodes the extra-cellular matrix protein periostin, is up-regulated in Dupuytren's disease cord tissue relative to phenotypically normal palmar fascia. We demonstrate that the protein product of POSTN, periostin, is abundant in Dupuytren's disease cord tissue while little or no periostin immunoreactivity is evident in patient-matched control tissues. The relevance of periostin up-regulation in DD was assessed in primary cultures of cells derived from diseased and phenotypically unaffected palmar fascia from the same patients. These cells were grown in type-1 collagen-enriched culture conditions with or without periostin addition to more closely replicate the in vivo environment. Periostinwas found to differentially regulate the apoptosis, proliferation, α smooth muscle actin expression and stressed Fibroblast Populated Collagen Lattice contraction of these cell types. We hypothesize that periostin, secreted by disease cord myofibroblasts into the extra-cellular matrix, promotes the transition of resident fibroblasts in the palmar fascia toward a myofibroblast phenotype, thereby promoting disease progression.

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“…However, the studies that advocated this approach did not compare this technique to other treatment options. 29,30 Roush and Stern 31 attempted to compare 3 different treatment options: dermofasciectomy with FTSG, limited fasciectomy with interphalangeal joint arthrodesis, and fasciectomy with local flaps. Although this study did not compare rate of recurrence, the authors did show that patients treated with fasciectomy with local flaps had a substantial difference of total active motion at final follow-up.…”

Section: Palmar Fasciectomymentioning

confidence: 99%