Long-Term Follow-Up of Multilayer Amniotic Membrane Transplantation (MLAMT) for Non-Traumatic Corneal Perforations or Deep Ulcers with Descemetocele

Berguiga, M.; Mameletzi, E.; Nicolas, Michaël; Rivier, Delphine; Majo, F.

doi:10.1055/s-0032-1328394

Cited by 22 publications

(17 citation statements)

References 12 publications

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“…When there is no donor cornea, the amniotic membrane should be accesible or we need to use a conjunctival flap to restore ocular surface integrity temporarily or definitely [6, 9]. …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Differences in Surgical Management of Corneal Perforations, Measured over Six Years

Krysik¹,

Dobrowolski

Lyssek-Boroń³

et al. 2017

Journal of Ophthalmology

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Purpose. To report the surgical approach, anatomical and functional results, and complications in the group of patients with corneal perforation. Materials and Methods. 247 eyes with corneal perforation were operated on between January 2010 and July 2016. The three surgical procedures, dependent on size and location of perforation, were performed: full-sized penetrating keratoplasty, corneoscleral patch graft, and anterior lamellar keratoplasty. The eyes underwent the minimum 6-month follow-up visit. Results. Between January 2010 and July 2016, 247 surgeries were performed: 116 penetrating keratoplasties, 117 corneoscleral patch grafts, and 14 anterior lamellar keratoplasties. More than one procedure was necessary in 32 eyes. Final improvement of the visual acuity, within a gain of 2 or more lines with the Snellen test, was achieved in 56 operated eyes. To achieve better final visual acuity, 75 eyes required successive surgical treatment. Complications of the surgery comprised persistent epithelial defect, glaucoma or ocular hypertension, corneal oedema, graft melting, loose corneal sutures, reinfection, anterior synechiae and fibrinoid membranes, and endophthalmitis. In 26 eyes, the treatment failure was reported. Conclusions. There is no one general-purpose surgical technique to treat corneal perforations. The complex nature of this pathology remains the individual, careful but also very distinct and multifactorial approach.

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“…When there is no donor cornea, the amniotic membrane should be accesible or we need to use a conjunctival flap to restore ocular surface integrity temporarily or definitely [6, 9]. …”

Section: Discussionmentioning

confidence: 99%

“…Surgical treatment includes tissue adhesives, amniotic membrane transplants, conjunctival flaps, pericardial membranes, tarsorrhaphy, and therapeutic ptosis with botulinum toxin [1, 6, 9–12]. …”

Section: Introductionmentioning

confidence: 99%

Differences in Surgical Management of Corneal Perforations, Measured over Six Years

Krysik¹,

Dobrowolski

Lyssek-Boroń³

et al. 2017

Journal of Ophthalmology

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“…74,75 Jain et al 33 have reported successful use of amniotic membrane in ocular rosacea with peripheral corneal ulceration if cyanoacrylate glue fails to seal the perforation despite repeated attempts ( Figures 5B, D-F). …”

Section: Surgical Treatmentmentioning

confidence: 99%

Ocular Rosacea—a Review

Dhingra¹,

Malhotra²,

Jain³

2017

US Ophthalmic Review

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Ocular rosacea, a disease often associated with acne rosacea, can present with a variety of clinical features, which are often nonspecific. However, in about one-third of cases, it may occur as an isolated entity without skin involvement. Appropriate diagnosis and management is essential as potentially sight-threatening corneal involvement can occur in a significant number of patients if the condition remains unrecognized and untreated. Diagnosis remains mainly clinical and includes recognition of the commonly occurring signs of chronic blepharoconjunctivitis, lid margin telangiectasis,meibomian gland dysfunction, dry eyes, and corneal involvement in the form of vascularization, infiltration, and even perforation. Management depends on the severity of the disease, with milder forms being amenable to treatment with local measures like lid hygiene and topical lubricants, while more severe forms require treatment with systemic drugs including tetracyclines, azithromycin, erythromycin, or metronidazole and more aggressive local therapy with topical steroids and/or topical cyclosporine. Surgical treatment may be required to manage the sequelae of chronic ocular surface inflammation.

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“…(Figure 3) The technique described by Berguiga involved the use of a sutured AMT first and then sliding additional membranes beneath the overlay to fill the stromal defect. (22)…”

Section: Amniotic Membrane Transplantationmentioning

confidence: 99%

“…(23) Similarly, Berguiga et al demonstrated a long-term benefit with 10 of 11 patients treated with multilayer AMT for deep ulcers and descemetoceles as well as non-traumatic perforations showing resolution that persisted for an average of 32 months. (22) More recently, Mohan et al showed an 82.1% success rate of ulcer healing with multilayered amniotic membrane transplantation at 1 month and 75% after 6 months using an “overlay on-inlay” technique. (24) Most recently, however, a large study by Uhlig et al of 108 patients with corneal ulcers showed a much lower success rate of approximately 50% whether an overlay or multilayer approach was used.…”

Section: Amniotic Membrane Transplantationmentioning

confidence: 99%

Surgical management of corneal infections

Tuli

Gray

2016

Current Opinion in Ophthalmology

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Purpose of review The purpose of this review is to discuss the options for, and recent developments in, the surgical treatment of corneal infections. While the mainstay of treatment of corneal infections is topical antimicrobial agents, surgical intervention may be necessary in a number of cases. These include advanced disease at presentation, resistant infections, and progressive ulceration despite appropriate treatment. Prompt and appropriate treatment can make the difference between a good outcome and loss of vision or the eye. Recent findings There are a number of surgical therapies available for corneal infections. Preferred therapeutic modalities differ based on the size, causation, and location of the infection but consist of either replacement of the infected tissue or structural support of the tissue to allow healing. While there are no completely novel therapies that have been developed recently, there have been incremental improvements in the existing treatment modalities making them more effective, easier, and safer. Summary Several options are available for surgically managing corneal infections. Ophthalmologists should select the optimal procedure based on the individual patient’s situation.

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Long-Term Follow-Up of Multilayer Amniotic Membrane Transplantation (MLAMT) for Non-Traumatic Corneal Perforations or Deep Ulcers with Descemetocele

Cited by 22 publications

References 12 publications

Differences in Surgical Management of Corneal Perforations, Measured over Six Years

Differences in Surgical Management of Corneal Perforations, Measured over Six Years

Ocular Rosacea—a Review

Surgical management of corneal infections

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