Long‐term follow‐up results of spine tumor treatment using high‐dose radiotherapy after <scp>3‐dimensional</scp>‐printed vertebral bodies implantation

Xiao, Yao; Wang, Yuxia; Wei, Feng; Zhuang, Hongqing

doi:10.1002/cam4.5867

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…Currently, robotic surgery is primarily used for precise screw placement in cases of spinal instability [ 67 ] and in hybrid surgeries involving extensive tumors extending into other cavities, as demonstrated by Iga et al, who combined spinal endoscopy with robot-assisted intrathoracic surgery using the da Vinci robot for a dumbbell-shaped tumor [ 68 ].…”

Section: Alternative Treatmentmentioning

confidence: 99%

Diagnostic and Therapeutic Insights into Spinal Glomangioma of a Unique Intradural, Extramedullary Presentation—Systematic Review

Czyżewski,

Litak,

Pasierb

et al. 2024

Diseases

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Contemporary literature lacks examples of intradural, extramedullary spinal glomangiomas. Moreover, glomus tumors in general are exceedingly rare among benign spinal tumors and are mostly located within epidural space or within intervertebral foramen, and only a few cases have been documented to date. This report provides a detailed analysis of the clinical presentation, imaging characteristics, surgical intervention, and pathological findings of a 45-year-old patient experiencing progressive locomotor deterioration. The tumor was surgically excised, and subsequent histological examination identified it as a representative of glomus tumors—a glomangioma. Notably, this represents a unique case as it was the first example of such a tumor being discovered intradurally. Radical surgical excision remains the modality of choice in most benign spinal tumors of this localization. Although the malignant transformation of glomus tumors within the spine has not been documented thus far, cases have arisen in other areas. Consequently, we will investigate potential oncological treatments for cases with malignant potential and highlight advancements in surgical techniques for benign intradural spinal tumors.

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Section: Alternative Treatmentmentioning

confidence: 99%

Diagnostic and Therapeutic Insights into Spinal Glomangioma of a Unique Intradural, Extramedullary Presentation—Systematic Review

Czyżewski,

Litak,

Pasierb

et al. 2024

Diseases

View full text Add to dashboard Cite

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Long‐term follow‐up results of spine tumor treatment using high‐dose radiotherapy after 3‐dimensional‐printed vertebral bodies implantation

et al. 2023

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Objective: To investigate the long-term safety and efficacy of high-dose radiotherapy after 3D-printed vertebral body implantation in the treatment of spinal tumors. Methods: Thirty-three participants were recruited between July 2017 and August 2019. 3D-printed vertebral bodies were implanted in each participant, followed by postoperative robotic stereotactic radiosurgery at a dose of 35-40 Gy/5f. The tolerance of the 3D-printed vertebral body and the participant to the high-dose radiotherapy were evaluated. In addition, the local control of tumor and the local progression-free survival of the study participants following 3D-printed vertebral body implantation and high-dose radiotherapy were measured as indexes of effectiveness.Results: Of the 33 participants included in the study, 30, including three participants (10%) with esophagitis of grade 3 or above and two participants (6.7%) with advanced radiation nerve injury, successfully underwent postoperative high-dose radiotherapy. The median follow-up was 26.7 months, and IQR was 15.9 months.Most participants had primary bone tumors with 27 cases (81.8%), and the rest had bone metastases in six cases (18.2%). After high-dose radiotherapy, the 3Dprinted vertebrae maintained good vertebral stability and exhibited histocompatibility, without implant fractures. The local control rates were 100%, 88%, and 85% 6 months, 1 year, and 2 years after high-dose radiotherapy, respectively. Tumors recurred in four participants (12.1%) during the follow-up period. The median local progression-free survival after treatment was 25.7 months, with a range of 9.6-33.0 months. Conclusion:High-dose radiotherapy for spinal tumors after 3D-printed vertebral body implantation is feasible, elicits low toxicity, and yields satisfactory tumor control.

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Clinical Application of 3D-Printed Artificial Vertebral Body (3DP AVB): A Review

Kiselev,

Zheravin

2024

JPM

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Introduction: The choice of prosthesis for vertebral body reconstruction (VBR) remains a controversial issue due to the lack of a reliable solution. The subsidence rate of the most commonly used titanium mesh cages (TMC) ranges from 42.5% to 79.7%. This problem is primarily caused by the differences in the elastic modulus between the TMC and bone. This review aims to summarize the clinical and radiological outcomes of new 3D-printed artificial vertebral bodies (3DP AVB). Methods: A literature search of PubMed, Scopus and Google Scholar was conducted to extract relevant studies. After screening the titles and abstracts, a total of 50 articles were selected for full-text analysis. Results: Preliminary data suggest fewer implant-related complications with 3DP AVB. Most comparative studies indicate significantly lower subsidence rates, reduced operation times and decreased intraoperative blood loss. However, the scarcity of randomized clinical trials and the high variability of the results warrant caution. Conclusion: Most literature data show an advantage of 3DP AVB in terms of the operation time, intraoperative blood loss and subsidence rate. However, long manufacturing times, high costs and regulatory issues are this technology’s main drawbacks.

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Long‐term follow‐up results of spine tumor treatment using high‐dose radiotherapy after 3‐dimensional‐printed vertebral bodies implantation

Cited by 3 publications

References 27 publications

Diagnostic and Therapeutic Insights into Spinal Glomangioma of a Unique Intradural, Extramedullary Presentation—Systematic Review

Diagnostic and Therapeutic Insights into Spinal Glomangioma of a Unique Intradural, Extramedullary Presentation—Systematic Review

Long‐term follow‐up results of spine tumor treatment using high‐dose radiotherapy after 3‐dimensional‐printed vertebral bodies implantation

Clinical Application of 3D-Printed Artificial Vertebral Body (3DP AVB): A Review

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