Long-Term Follow-Up Study of Gastric Emptying and Helicobacter Pylori Eradication among Patients with Functional Dyspepsia

Koskenpato, Jari; Korppi-Tommola, T; Kairemo, Kalevi; Färkkilä, Martti

doi:10.1007/978-3-0348-8782-3_39

Cited by 15 publications

(31 citation statements)

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“…Some studies have reported changes in gastric emptying after H. pylori eradication, but no defi nite conclusions have been reached. [27][28][29][30] Recent studies have suggested that there is no correlation between H. pylori infection and 30 In this study, the range and SD of GEC was smaller than those of t1/2 and tlag in all groups, which may explain why only GEC and not tlag or t1/2 differed signifi cantly between IDDM and NIDDM patents.…”

Section: Discussioncontrasting

confidence: 71%

Gastric emptying in diabetic patients by the 13C-octanoic acid breath test: role of insulin in gastric motility

et al. 2007

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Section: Discussioncontrasting

confidence: 71%

Gastric emptying in diabetic patients by the 13C-octanoic acid breath test: role of insulin in gastric motility

et al. 2007

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“…Kachi et al [8], as well as Miyaji et al [23], reported that GE was improved by H. pylori eradication in patients with initially disturbed gastric evacuation. On the other hand, Koskenpato et al did not observe statistically significant differences in GE between H. pylori-eradicated and placebo-treated patients after 1 year [21]. Tucci et al reported that although generally GE was not changed after H. pylori eradication, some patients with delayed GE at entry had normal GE after eradication [24].…”

Section: Discussionmentioning

confidence: 97%

“…Gastric antral inflammation, independently of H. pylori infection, may induce smooth muscle alteration and consequently delayed emptying [20]. A tendency towards delayed GE among dyspeptic patients, but only a minor association between GE speed and the symptoms of dyspepsia, was described [17,21]. In the study performed by Koskenpato et al, dyspeptic patients tended to have a prolonged GE of solids, although the difference vs. healthy controls was not statistically significant [21].…”

Section: Discussionmentioning

confidence: 99%

“…A tendency towards delayed GE among dyspeptic patients, but only a minor association between GE speed and the symptoms of dyspepsia, was described [17,21]. In the study performed by Koskenpato et al, dyspeptic patients tended to have a prolonged GE of solids, although the difference vs. healthy controls was not statistically significant [21]. In a previous study of this research group the effect of H. pylori seemed to be less important in multivariate analysis than some other factors [22].…”

Section: Discussionmentioning

confidence: 99%

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Effect of Helicobacter pylori eradication on gastric emptying and symptoms in patients with dyspepsia

Waluga¹,

Jonderko²,

Krusiec-Świdergoł³

et al. 2011

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Aim: To study whether eradication of Helicobacter pylori (H. pylori) in patients with functional dyspepsia affects gastric emptying (GE) and concomitantly relieves their clinical symptoms. Material and methods: Eighteen H. pylori-positive patients suffering from functional dyspepsia were recruited. At entrance and two weeks after successful H. pylori eradication they filled in a questionnaire examining the intensity of dyspeptic symptoms and underwent measurement of GE of a 378 kcal solid test meal labelled with 75 μl of 13 C-octanoic acid. Normative values of GE were obtained in 12 healthy controls. Results: Helicobacter pylori eradication was attained in 17 patients. The duration of the lag phase (T_Lag) of the GE did not change after the eradication (mean ± SD 144.5 ±23.2 min) vs. before the eradication (152.1 ±27.6 min). On the other hand, the gastric half emptying time (T 1/2 ) increased statistically significantly from 207.1 ±33.5 min before eradication to 229.5 ±49.4 min (p = 0.0217). Considering the whole patient group, the H. pylori eradication did not significantly affect the dyspeptic symptoms. It was established, however, that the deterioration of the score for fullness or satiety was dependent on the increase in the T_Lag. Also the aggravation of pain, burning or satiety was related to the prolongation of the T 1/2 . Conclusions: 1) Eradication of H. pylori in patients with functional dyspepsia prolongs the gastric half emptying time of a solid meal without eliciting a significant symptomatic improvement.2) The worsening of dyspeptic symptoms may be related to sluggish gastric emptying. StreszczenieCel: Ustalenie, czy eradykacja Helicobacter pylori (H. pylori) u chorych z dyspepsją czynnościową wpływa na szybkość opróżniania żołądka (gastric emptying -GE) i złagodzenie towarzyszących objawów klinicznych. Materiał i metody: W badaniu wzięło udział 18 chorych z infekcją H. pylori cierpiących na dyspepsję czynnościową. W czasie włączania do badania oraz 2 tyg. po skutecznej eradykacji wypełniali oni kwestionariusz mający na celu określe-nie nasilenia objawów dyspeptycznych oraz zostali poddani pomiarowi GE z posiłku stałego o wartości energetycznej 378 kcal z dodatkiem 75 μl 13 C-kwasu oktanowego. Wartości normatywne kinetyki GE wyznaczono u 12 zdrowych osób. Wyniki: Eradykację H. pylori uzyskano u 17 chorych. Czas trwania fazy opóźnienia GE (T_Lag) nie zmienił się po eradykacji (średnia ± SD 144,5 ±23,2 min) w porównaniu z czasem przed eradykacją (152,1 ±27,6 min). Półokres GE (T 1/2 ) natomiast zwię kszył się statystycznie znamiennie z 207,1 ±33,5 min przed eradykacją do 229,5 ±49,4 min po eradykacji (p = 0,0217). Biorąc pod uwagę całą grupę chorych, eradykacja H. pylori nie wpłynęła znamiennie na objawy dyspeptyczne. Wykazano jednak, że pogorszenie punktacji w skali oceny uczucia pełności lub wczesnej sytości zależało od wzrostu długości T_Lag, podczas gdy zwiększenie odczucia bólu, pieczenia i pełności od wydłużenia T 1/2 . Wnioski: 1) Eradykacja H. pylori u chorych z dyspepsją czynnościową...

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“…A region of interest corresponding to stomach was outlined and the gastric counts for each frame were determined. After performing a correction for the background elements and the radioactive decay, the time-activity curve was generated; and to determine the half-time for GET , the time point at which 50 % of the radioactive content had exited the stomach and the emptying ratio at 2 h were analyzed using Xeleris Workstation (General Electric, USA) [12]. The GE test results were interpreted by the Ankara University Department of Nuclear Medicine.…”

Section: Gastric Emptying Studymentioning

confidence: 99%

Relationships between autonomic nerve function and gastric emptying in patients with autoimmune gastritis

et al. 2016

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Long-Term Follow-Up Study of Gastric Emptying and Helicobacter Pylori Eradication among Patients with Functional Dyspepsia

Cited by 15 publications

References 4 publications

Gastric emptying in diabetic patients by the 13C-octanoic acid breath test: role of insulin in gastric motility

Gastric emptying in diabetic patients by the 13C-octanoic acid breath test: role of insulin in gastric motility

Effect of Helicobacter pylori eradication on gastric emptying and symptoms in patients with dyspepsia

Relationships between autonomic nerve function and gastric emptying in patients with autoimmune gastritis

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