Long-Term Follow-Up Study of Idiopathic Nephrotic Syndrome (Ins) in Childhood

Abstract

The purpose of the present study Is to investigate the role of HBe antlgen In the pathogenesbs of membranous glomerulonephr~t~s (MGNI In Japanese chtldren. Of 364 chtldren who underwent renal blopsy from 1976 through 1978 in our inst~tution.Il(lO male, 1 female, qles 1-14 years1 were found to be HBs antigen carrlers and comprise the subject of the present study All of them exhibited some abnormaltty on a routine urinalysis at one tlme during the courre. Serum HB associated antigens were studled in all. A routine Itght. fluorescent and electron microscop~c study was performed on 14 biopsied specimens from the Ilch~ldren. I n addltlon, direct ~mmunofluorescence for HBsAg, HBeAg & HBcAg was done ~n the majority of the specimens. The results are summerized in the table. The 14 soeclmens were divided into 2 urouos de. pend~ng upon clnntcal man~festat~ons at the tome of renal b~opsy I G r o~p A 9 specamens from 9 choldren wltn nepnrot~c syndrome or heavy prote4nur.a. Grodp B 5 specimens from 4 ch Id