Long-Term Functioning of Patients with Aneurysmal Subarachnoid Hemorrhage

Boerboom, Wendy; Heijenbrok‐Kal, Majanka H.; Khajeh, Ladbon; Kooten, Fop van; Ribbers, Gerard M.

doi:10.1097/phm.0000000000000353

Cited by 24 publications

(12 citation statements)

References 27 publications

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“…Moreover, some research suggests that increased SWS is found among patients with chronic fatigue syndrome [76,77]. Thus, the fact that a relatively large portion of aSAH patients (50-70%) suffer from severe and stable fatigue symptoms [7,8,30,78] might explain why deep sleep is increased in this patient group. In other words, in aSAH patients, long S4 sleep might rather be an indication of chronic fatigue than of restoring sleep, although the absence of a measure of chronic fatigue in this study means that this observation cannot be confirmed for the present sample.…”

Section: Discussionmentioning

confidence: 98%

“…Boerboom et al [7] examined 76 patients following treatment and at 4-year follow-up, and found that while some measures improved, depression scores remained constant. Elevated levels of depression, even several years post-ictus, have been documented in another study [8], and numerous articles report mild-to-moderate depression rates of between 14 and 39% in this population [9,10,11].…”

Section: Introductionmentioning

confidence: 99%

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Sleep Quality, Sleep EEG Pattern, Mental Well-Being and Cortisol Secretion in Patients with Ruptured Aneurysm Post-Treatment: A Comparison with Post-Surgery Meningioma Patients and Controls

et al. 2016

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Background: Although the chance of surviving an aneurysmal subarachnoid haemorrhage (aSAH) has increased steadily, disturbed sleep and persistent psychological complaints are frequently experienced post-ictus. To date, however, few studies have sought to determine whether physiological parameters, such as objectively measured sleep and cortisol secretion, interrelate significantly with low sleep quality and psychological complaints such as depression. Furthermore, there is little evidence as to whether post-ictal complaints differ between aSAH patients and other groups who have experienced stressful medical intervention. Methods: Data on objective and subjective sleep, sleep-related dysfunctional cognitions, psychological functioning and cortisol secretion were collected from 15 patients who had undergone medical intervention for aSAH. Data were also collected from a group of 16 individuals who had undergone surgery for a meningioma and a third group made up of 17 healthy participants. Results: aSAH patients and meningioma patients had significantly poorer subjective sleep than healthy controls and reported more sleep-related dysfunctional cognitions and hypochondriacal beliefs. They also had a significantly higher morning cortisol response. Finally, a non-significant trend was found showing that aSAH patients and meningioma patients reported poorer psychological functioning than healthy controls. Conclusion: Following treatment, aSAH patients and meningioma patients experience poorer subjective sleep and some differences in objectively measured sleep, which might be attributable to increased sleep-related dysfunctional cognitions and poorer overall psychological functioning. Differences in cortisol production were also observed, suggesting that some physiological imbalances are still present post-ictus.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Sleep Quality, Sleep EEG Pattern, Mental Well-Being and Cortisol Secretion in Patients with Ruptured Aneurysm Post-Treatment: A Comparison with Post-Surgery Meningioma Patients and Controls

et al. 2016

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“…In order to identify the stimulus features that optimally discriminate between bursts of different duration, we turn to multi-discriminant analysis (MDA) (Duda et al, 2001 ; Kepecs and Lisman, 2003 ). The criterion to define the optimal discrimination is based on Fisher's Linear Discriminant (Fisher, 1936 ).…”

Section: Methodsmentioning

confidence: 99%

Thalamic neuron models encode stimulus information by burst-size modulation

Elijah

Samengo

Montemurro

2015

Front. Comput. Neurosci.

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Thalamic neurons have been long assumed to fire in tonic mode during perceptive states, and in burst mode during sleep and unconsciousness. However, recent evidence suggests that bursts may also be relevant in the encoding of sensory information. Here, we explore the neural code of such thalamic bursts. In order to assess whether the burst code is generic or whether it depends on the detailed properties of each bursting neuron, we analyzed two neuron models incorporating different levels of biological detail. One of the models contained no information of the biophysical processes entailed in spike generation, and described neuron activity at a phenomenological level. The second model represented the evolution of the individual ionic conductances involved in spiking and bursting, and required a large number of parameters. We analyzed the models' input selectivity using reverse correlation methods and information theory. We found that n-spike bursts from both models transmit information by modulating their spike count in response to changes to instantaneous input features, such as slope, phase, amplitude, etc. The stimulus feature that is most efficiently encoded by bursts, however, need not coincide with one of such classical features. We therefore searched for the optimal feature among all those that could be expressed as a linear transformation of the time-dependent input current. We found that bursting neurons transmitted 6 times more information about such more general features. The relevant events in the stimulus were located in a time window spanning ~100 ms before and ~20 ms after burst onset. Most importantly, the neural code employed by the simple and the biologically realistic models was largely the same, implying that the simple thalamic neuron model contains the essential ingredients that account for the computational properties of the thalamic burst code. Thus, our results suggest the n-spike burst code is a general property of thalamic neurons.

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“…With a mean age of onset between 55 and 57 years, a comparatively young population is affected by this form of stroke [3], and difficulties in resuming normal life following aSAH have been widely documented. Depression [4-6], anxiety [5, 7], post-traumatic stress disorder [8, 9], and concerns about sleep (that is, worries and negative attitudes to sleep duration and quality) [8, 10] were chief among the psychiatric disorders and deficits in well-being reported by patients following aSAH. Some studies have also found sleep disorders during objective sleep assessment [10], although others have reported no deficits in this domain, in spite of poor subjectively assessed sleep [11].…”

Section: Introductionmentioning

confidence: 99%

A Twelve-Week Moderate Exercise Programme Improved Symptoms of Depression, Insomnia, and Verbal Learning in Post-Aneurysmal Subarachnoid Haemorrhage Patients: A Comparison with Meningioma Patients and Healthy Controls

et al. 2017

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Objectives: Deficits in psychological functioning, cognitive functioning, and sleep are frequently experienced by individuals who have survived aneurysmal subarachnoid haemorrhage (aSAH). Exercise has been shown to improve these domains; to date, it has never been explored in patients following aSAH. The aim of this exploratory study is to compare the effects of an exercise programme in this population with another patient group, and a group of healthy controls. Methods: The present study explored the effects of 12 weeks of moderate aerobic exercise training on 15 aSAH patients, 16 meningioma patients, and 17 healthy controls. Data on symptoms of depression, hypochondria, perceived stress, satisfaction with life, verbal learning and memory, and subjective and objective sleep, were gathered at baseline, following intervention, and at 6-month follow-up. Results: aSAH patients and meningioma patients had decreased symptoms of depression and insomnia at follow-up. While perceived stress decreased in the meningioma group, in aSAH patients it increased. Total learning performance increased in all three groups. Conclusions: An exercise programme had a positive effect on symptoms of depression, insomnia, and verbal learning in patients following aSAH. No positive changes in other domains were observed. This may be due to the cautious approach taken with regard to exercise intensity.

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Long-Term Functioning of Patients with Aneurysmal Subarachnoid Hemorrhage

Abstract: Many patients with aneurysmal subarachnoid hemorrhage had fairly good long-term outcomes, but problems in executive functioning, mood, and fatigue still exist at long-term follow-up.

Cited by 24 publications

References 27 publications

Sleep Quality, Sleep EEG Pattern, Mental Well-Being and Cortisol Secretion in Patients with Ruptured Aneurysm Post-Treatment: A Comparison with Post-Surgery Meningioma Patients and Controls

Sleep Quality, Sleep EEG Pattern, Mental Well-Being and Cortisol Secretion in Patients with Ruptured Aneurysm Post-Treatment: A Comparison with Post-Surgery Meningioma Patients and Controls

Thalamic neuron models encode stimulus information by burst-size modulation

A Twelve-Week Moderate Exercise Programme Improved Symptoms of Depression, Insomnia, and Verbal Learning in Post-Aneurysmal Subarachnoid Haemorrhage Patients: A Comparison with Meningioma Patients and Healthy Controls

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