Long-term Graft Survival in Patients with Down Syndrome after Penetrating Keratoplasty

Wroblewski, Keith J.; Mader, Thomas H.; Torres, Mark F.; Parmley, Vernon C.; Rotkis, Walter M.

doi:10.1097/01.ico.0000226053.61884.91

Cited by 14 publications

(8 citation statements)

References 8 publications

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“… 5 – 10 Along with improvements in corneal imaging, surgical instrumentation, and preoperative patient’s care, the success rate of the corneal transplantation surgery has been reported to be as high as 80% worldwide. 11 – 13 …”

Section: Introductionmentioning

confidence: 99%

Public attitudes toward corneal donation in northern Jordan

Haddad

Khabour

Alzoubi

2018

OPTH

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PurposeThe aims of this study were to assess the knowledge and attitude toward corneal donation among Jordanian population and to report the reasons which may influence subject’s decision and attitude toward corneal donation.MethodsA self-designed questionnaire was developed. The participants were asked about reasons for both willingness and unwillingness to donate their corneas. These reasons were stated in the questionnaire and the participants had to express their agreement by one of five options: strongly disagree, disagree, neutral, agree, or strongly agree.ResultsA total of 500 participants (218 males and 282 females) completed the questionnaire. The average age (±SD) of the study participants was 32.8 (±11.7) years. About 67.2% of the subjects were willing to donate their corneas, whereas 32.8% were not willing to do so. The main motive for willingness was doing a good deed by helping others to see. On the other hand, fear of the body being treated badly and that other organ might be taken than the ones specified for donation were the main reasons for unwillingness to donate corneas. The age of participants, gender, and the monthly income did not significantly influence the willingness to donate (P>0.05). However, the level of education had a significant influence on people’s decision to donate their corneas.ConclusionMany Jordanians have positive attitude toward corneal donations. Ethical factors need to be addressed to promote for corneal donation. In addition, increasing the awareness of donation and its benefits may help increase the supply of corneal tissues.

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Section: Introductionmentioning

confidence: 99%

Public attitudes toward corneal donation in northern Jordan

Haddad

Khabour

Alzoubi

2018

OPTH

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“…Some patients had complicated follow-up periods due to broken sutures and difficulties with suture removal. 18 A factor determining long-term graft survival, in patients with learning disabilities, is postulated to be dependent on conscientiousness of the care takers with the postoperative care.…”

Section: Discussionmentioning

confidence: 99%

Clinical Dilemmas in the Management of a Monocular Patient with Down's Syndrome, Dementia, Advanced Keratoconus, and a Mature Cataract

Nanavaty¹,

Ali²

2016

International Journal of Keratoconus and Ectatic Corneal Diseases

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There are reports on the successful management of mild to moderate keratoconus in patients with Down's syndrome. However, when Down's syndrome is coexistent with Dementia, poor general health, and very advanced keratoconus in only one eye, then clinicians may face challenges at all stages from diagnosis, treatment, and follow-up. Our case is one such example of a combination of Down's syndrome, Dementia, poor general health, and very advanced keratoconus with a white cataract in the only functioning eye. This report highlights the dilemmas which were encountered and learning points on selection of the safest, yet effective management options in such patients. How to cite this article Ali H, Nanavaty MA. Clinical Dilemmas in the Management of a Monocular Patient with Down's Syndrome, Dementia, Advanced Keratoconus, and a Mature Cataract. Int J Kerat Ect Cor Dis 2016;5(2):81-84.

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“…Furthermore, this may avoid persons reaching advanced stages, where corneal transplantation with a long postoperative follow-up may become necessary; a treatment that is particularly complicated in Down syndrome patients. 60 A considerable proportion of persons with Down syndrome has visual impairment, 21 and advanced stage keratoconus is likely one of the reasons.…”

Section: Open Accessmentioning

confidence: 99%

Prevalence of keratoconus in persons with Down syndrome: a review

Kristianslund

Drolsum

2021

BMJ Open Ophth

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PurposeKeratoconus is a vision-threatening condition, and there is a need for knowledge about the occurrence in subgroups of the population. The progression of the disease can be effectively stopped, and vision may be restored, if keratoconus is diagnosed at an early stage. The purpose of this review was to evaluate the literature of the prevalence of keratoconus in persons with Down syndrome.MethodsWe conducted a literature review of keratoconus prevalence in persons with Down syndrome. A thorough search was performed in Pubmed (Medline), and the quality of evidence was evaluated.ResultsThe literature review identified 20 relevant studies, which reported keratoconus in 0%–71% of persons with Down syndrome. These studies varied greatly in design, patient selection, sample sizes and mean age, and the quality of evidence concerning estimates for the prevalence of keratoconus was generally evaluated as low. Most studies that included adults reported high prevalences of keratoconus–in many studies more than 10-fold the prevalence in the general population. No large screening studies in persons with Down syndrome were identified.ConclusionsThe present review showed that the prevalence of keratoconus in persons with Down syndrome is higher than in the general population. However, estimates from previous studies vary widely. Screening for keratoconus in this group should be considered.

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Long-term Graft Survival in Patients with Down Syndrome after Penetrating Keratoplasty

Abstract: Clear grafts and improvements in visual acuity can be obtained after PK in patients with Down syndrome, but consideration must be given to careful postoperative care by health care providers and home support personnel.

Cited by 14 publications

References 8 publications

Public attitudes toward corneal donation in northern Jordan

Public attitudes toward corneal donation in northern Jordan

Clinical Dilemmas in the Management of a Monocular Patient with Down's Syndrome, Dementia, Advanced Keratoconus, and a Mature Cataract

Prevalence of keratoconus in persons with Down syndrome: a review

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