Long‐term histological outcomes of injected autologous fat into human vocal folds after secondary laryngectomy

Abstract

Our liposuctioned autologous fat injection histologically offered long-term improvement in patients with impaired glottal closure from vocal fold paralysis.

Treatment of vocal cord paralysis by autologous fat injection: Our experience with 41 patients

“…There was also a statistically sig- The improvement in voice quality parameters observed in this study is consistent with those in previous studies. [5][6][7][8] For instance, a study on 33 patients with UVCP in Taiwan observed that jitter had improved from 2.7 at baseline to 1.3 at month 3, 5 which is comparable with our observed effect size. Hartl and colleagues also observed that acoustic parameters (eg, jitter and shimmer) reduced quickly after one month of surgery and maintained up to 24 months.…”

“…The improvement in voice quality parameters observed in this study is consistent with those in previous studies . For instance, a study on 33 patients with UVCP in Taiwan observed that jitter had improved from 2.7 at baseline to 1.3 at month 3, which is comparable with our observed effect size.…”

Autologous fat augmentation for phonatory gap: Prospective study of postoperative voice outcome

“…Various studies have reported the absorption rates between 6 months and 2.5 years. [21] In spite of this, our results and those reported in other such studies are encouraging. The longstanding good vocal outcome would not necessarily mean nonabsorption of fat, but it could also be due to good compensation over time or recovery of vocal cord parlaysis.…”

Histologic Study of an Autologous Fat Graft in the Larynx of Dogs With Unilateral Vocal Fold Paralysis

“…Histology revealed viable adipocytes with a minimal inflammatory response in both patients. The authors concluded that, even though there is debate about the negative effects of liposuction compared to those of fat obtained by the open technique, the liposuction technique can keep the fatty tissue viable 18 . However, it was not possible to determine the amount of fat that survived in the two larynges studied since the injected volume was not measured, so that the result—presence of viable adipocytes—was of little clinical significance.…”

“…There was no statistically significant difference in histologic findings between the groups submitted to the three types of treatment, i.e., use of insulin, grafting by endoscopic injection, and grafting by an open technique. Indeed, there is no consensus about this topic, with some studies showing an almost total loss of fat 4,16 mainly by liposuction, and others reporting surprising results 18,19 . In view of the countless variables involved, it is always very difficult to determine what really modifies the capacity for fat survival.…”