Long-Term Histological Study of Skin After Chemical Face Peeling

Histologic Changes in the Skin of Hairless Mice Following Peeling With Salicylic Acid

“…These acidic solutions chemically denature, and ultimately lead to the peeling away of, parts of the epidermis and the dermis. Although controlled wounding and inflammation are thought to lead to regeneration of the epidermis and the connective tissue during healing, [1][2][3][4] the mechanisms responsible for the cosmetic effects of chemical peeling have not been satisfactorily explained. Clinical and experimental studies suggest that degeneration or inflammation is not required to achieve the epidermal as well as the dermal regeneration.…”

“…If this were the case, one could safely induce chemical peeling of the skin of Asians, who are at a higher risk for pigmentary disorders and keloids than most whites. 1,2 Wounding is associated with a risk of scarring.…”

“…[1][2][3][4] However, injury to the superficial epidermis occurs with all types of chemical peeling. [2][3][4][5][6][7] This is also the case with laser peeling, which removes tissue by heating the superficial layer of skin.…”

Chemical Peels in der �sthetischen Dermatologie

“…Die von Baker und Gordon beschriebene Peelmethode wurde erst 10 Jahre später nach sorgfältig dokumentierten und kontrollierten klinischen und histologischen Studien ihrer Patienten anerkannt [5].…”

“…Durch Steigerung der Konzentration der α-Hydroxysäuren kann der milde schälende Effekt verstärkt werden bis hin zur Epidermolyse. Untersuchungen von Hautbiopsien zeigen, dass α-Hydroxysäuren die Synthese von Glykosaminoglykan sowie die Bildung von neuem Kollagen in der papillären Dermis stimulieren können [7], obwohl 70% Glykolsäu-re bei einer Kontaktzeit bis 7 min [5] bei den meisten Patienten nicht bis ins Stratum papillare eindringt.…”