2015
DOI: 10.1021/acsnano.5b00552
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Long-Term in Vivo Clearance of Gadolinium-Based AGuIX Nanoparticles and Their Biocompatibility after Systemic Injection

Abstract: We previously reported the synthesis of gadolinium-based nanoparticles (NPs) denoted AGuIX (activation and guiding of irradiation by X-ray) NPs and demonstrated their potential as an MRI contrast agent and their efficacy as radiosensitizing particles during X-ray cancer treatment. Here we focus on the elimination kinetics of AGuIX NPs from the subcellular to whole-organ scale using original and complementary methods such as laser-induced breakdown spectroscopy (LIBS), intravital two-photon microscopy, inductiv… Show more

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Cited by 141 publications
(128 citation statements)
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“…The design of the AGuIX NPs has been made in order to ensure a fast and exclusive renal elimination and to avoid toxicity concerns [9,12,21,22]. The present work was designed to assess the passive accumulation of 68 GaAGuIX@NODAGA in a U87MG tumor model, both by ex vivo biodistribution studies and in vivo PET and MR imaging studies.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The design of the AGuIX NPs has been made in order to ensure a fast and exclusive renal elimination and to avoid toxicity concerns [9,12,21,22]. The present work was designed to assess the passive accumulation of 68 GaAGuIX@NODAGA in a U87MG tumor model, both by ex vivo biodistribution studies and in vivo PET and MR imaging studies.…”
Section: Discussionmentioning
confidence: 99%
“…As toxicity is always a major concern with gadolinium-based MRI contrast agents, Sancey et al evaluated the maximum tolerated dose of AGuIX NPs [22]. For in vivo application in mice, it was proven that after bolus injection of these NPs, no toxicity effects were shown at doses up to ten-times higher than the ther- apeutic dose, which corresponds to an injection of 8 μmol of [Gd 3+ ].…”
Section: Discussionmentioning
confidence: 99%
“…An NP called AGuIX was used; it is composed of gadolinium chelates, DOTAGA, 2,2′,2″-(10-(2,6-dioxotetrahydro-2H-pyran-3-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl) triacetic acid, covalently grafted to a polysiloxane core; its synthesis and properties have already been presented in the literature. 36,[44][45][46][47][48] A PS, a tetraphenylporphyrin (TPP) and a peptide (KDKPPR) targeting the NRP-1 receptor overexpressed by tumor angiogenic vessels were then grafted on the surface of this particle. The choice of the AGuIX NPs was driven by several points.…”
Section: Discussionmentioning
confidence: 99%
“…The imaging capability of Laser-induced breakdown spectroscopy (LIBS) represents an attractive way of development for the technique, with innumerable applications in various fields, such as geology [1][2][3], industry [4][5][6][7][8], surface science [9,10] and biology [11][12][13][14][15]. In LIBS imaging, laser-induced plasma are generated continuously while scanning the sample surface over the region of interest.…”
Section: Introductionmentioning
confidence: 99%