Long-Term Immunogenicity of an Inactivated Split-Virion 2009 Pandemic Influenza A H1N1 Virus Vaccine with or without Aluminum Adjuvant in Mice

Xu, Wenting; Zheng, Mou‐Xiong; Zhou, Feng; Chen, Ze

doi:10.1128/cvi.00662-14

Cited by 9 publications

(10 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The obvious increase in the counts of the CD4+ thymocytes in animals which received IMI by the supplemented vaccine with E compared with mice which received the un-supplemented V or the E separately via the same route further suggests the improvement of the antigenicity of the V by the E which can be attributed to induced structural changes. This agrees with previous reports on conformational changes induced in some vaccines due to treatment with adjuvants [38][39][40][41]. As for the CD8+ thymocytes, absence of significant differences between animals which received IMI with either V, VE, or VN and the obvious significant differences between their levels in the three animal groups compared with mice which received either E or N alone confirm that the induction is mainly due to the V antigens.…”

Section: Supplemented Killed Virus With E or N (Ve And Vn)supporting

confidence: 92%

“…The significant decreases seen in the levels of IgM at 3 rd and 4 th WPIMI or WPIPI with the supplemented vaccine by E compared with the V alone reflected a regulatory effect of the E on the induced IgM response by the V. This could be partially explained to be due to denaturing some of the antigenic determinant of the V by the E [38][39][40][41]. It falls in agreement with a previous report on a possible immune suppressive effect by E [35].…”

Section: Supplemented Killed Virus With E or N (Ve And Vn)supporting

confidence: 90%

“…The observed significant increase in the IgM upon IMI of mice with supplemented V with N in comparison with the treated animals with the unsupplemented V reveals an immunostimulatory effect of the N. This can be due to a direct effect of the plant extract on the host immune response [18] or due to an indirect effect of the N that leads to chemical structural modification (epitope exposure) of the V [38][39][40][41]. Although IPI with VN still caused a significant increase in IgM levels compared with the control animals, interestingly, an opposite effect was seen, i.e., significantly less stimulation of IgM in case of treating mice with supplemented vaccine by N compared with V alone.…”

Section: Supplemented Killed Virus With E or N (Ve And Vn)mentioning

confidence: 92%

See 2 more Smart Citations

Immune responses to killed reassorted influenza virus supplemented with natural adjuvants

Razin

Osman

Ali

et al. 2017

Acta Microbiologica et Immunologica Hungarica

View full text Add to dashboard Cite

In this study, we investigated the immunomodulatory effects of a supplemented killed influenza virus (V) by Echinacea purpurea (E) and Nigella sativa (N) extracts and effect of changing the route of immunization from intramuscular (IM) to intraperitoneal (IP). At the 2-, 3- and 4-week post-IM immunizations (WPIMI), the supplemented V with N (VN) induced the most significant IgM response unlike N alone. At the 2 WPIMI, V or VN induced the highest significant IgG levels. At the 2-week post-IP immunization (WPIPI), E and VN induced the most significant IgG levels. Both at the 3 and 4 WPIMI or WPIPI, various treatments induced significant increases in IgG. At the 4 WPIMI, E, V, and V with E (VE) induced significant increases in the CD4+ thymocytes while all IP treatments caused significant increase in their counts. V and VN induced the most significant IM induction of CD8+ thymocytes while their best IP stimulation was induced by N, VE, and VN. At the 4 WPIMI, various treatments caused significant increases in the mesenteric lymph node (MLN) CD4+, CD8+ counts. WPIPI with V or VE caused significant increases in both the CD4+- and CD8+ MLN cells, whereas VN significantly induced CD8+ MLN cells only. WPIPI with various treatments caused significant increases in the B-cell counts and the peak was obtained by VN.

show abstract

Section: Supplemented Killed Virus With E or N (Ve And Vn)supporting

confidence: 92%

Section: Supplemented Killed Virus With E or N (Ve And Vn)supporting

confidence: 90%

Section: Supplemented Killed Virus With E or N (Ve And Vn)mentioning

confidence: 92%

See 1 more Smart Citation

Immune responses to killed reassorted influenza virus supplemented with natural adjuvants

Razin

Osman

Ali

et al. 2017

Acta Microbiologica et Immunologica Hungarica

View full text Add to dashboard Cite

show abstract

“…The search for new biomarkers that can reflect the bioactivity assessed in the ATT and LTT was conducted by performing comprehensive gene expression analyses on major organs via the microarray technology [25]. Inactivated influenza vaccines have been widely used for preventing infections and the spread of infections; they can roughly be subdivided into two types: the HAV and WPV [30]. The HAV mainly contains hemagglutinin (HA).…”

Section: The Genomic Approach To Identifying Novel Biomarkers Of Inflmentioning

confidence: 99%

“…antibody production is considered insufficient to prevent the progression of influenza virus infection [30]. Historically, however, vaccines have been more effective than the existing split vaccines.…”

Section: Ngfrmentioning

confidence: 99%

Genomic Approaches Enable Evaluation of the Safety and Quality of Influenza Vaccines and Adjuvants

Mizukami¹,

Hamaguchi²

2018

Influenza - Therapeutics and Challenges

View full text Add to dashboard Cite

Vaccination is an effective means for prevention of the progression and spread of influenza virus infection. Nonetheless, there is a risk of adverse reactions, such as pain and fever, during the vaccination. In addition, because people from a wide age range, that is, from children to the elderly, are inoculated with vaccines, safety confirmation of these vaccines is important. Safety assessments of a vaccine, in the form of quality controls, have been carried out on animals. For example, the abnormal toxicity test is based on body weight changes as a toxicity index, and the leukopenic toxicity test can evaluate hematological toxicity. Meanwhile, since the 2000s, safety evaluation of drugs and chemicals by the genomic approach has been conducted frequently. The benefits with respect to safety evaluation are high sensitivity and abundant information about toxicity profiles. In this chapter, we describe the genes that are helpful as safety assessment markers and their usefulness for safety testing and vaccine development. In addition, this information may provide toxicity profiles, help understand the reactogenicity of nasal vaccines or adjuvants, and explain the prospects of genomic analyses in the development of novel vaccines and adjuvants.

show abstract

Gastrodin, a traditional Chinese medicine monomer compound, can be used as adjuvant to enhance the immunogenicity of melanoma vaccines

Liu

Wang

Zhang

et al. 2019

International Immunopharmacology

View full text Add to dashboard Cite

Long-Term Immunogenicity of an Inactivated Split-Virion 2009 Pandemic Influenza A H1N1 Virus Vaccine with or without Aluminum Adjuvant in Mice

Cited by 9 publications

References 32 publications

Immune responses to killed reassorted influenza virus supplemented with natural adjuvants

Immune responses to killed reassorted influenza virus supplemented with natural adjuvants

Genomic Approaches Enable Evaluation of the Safety and Quality of Influenza Vaccines and Adjuvants

Gastrodin, a traditional Chinese medicine monomer compound, can be used as adjuvant to enhance the immunogenicity of melanoma vaccines

Contact Info

Product

Resources

About