Long-term in vivo observations show biocompatibility and performance of ZX00 magnesium screws surface-modified by plasma-electrolytic oxidation in Göttingen miniature pigs

Kopp, Alexander; Fischer, Heilwig; Soares, Ana Prates; Schmidt‐Bleek, Katharina; Leber, Christoph; Kreiker, Henri; Duda, Georg N.; Kröger, Nadja; Gaalen, Kerstin van; Hanken, Henning; Jung, Ole; Smeets, Ralf; Heiland, Max; Rendenbach, Carsten

doi:10.1016/j.actbio.2022.11.052

Cited by 18 publications

(12 citation statements)

References 40 publications

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“…Calcium phosphate MAO coating on Mg-Sr alloy exhibited the greatest performance in terms of alloy degradation, cell proliferation and alkaline phosphatase activity when compared to Sr-P and Ca-P PED coatings, suggesting it could hold potential for use in orthopedics [ 20 ]. Regarding the use of PEO, Kermasorb ® demonstrated its biocompatibility and ability to reduce the rate of degradation of ZX00 alloy, which was also confirmed by the presence of residual material up to 18 months after implantation, and improved its osseointegration [ 48 ]. The ability of PEO to control the degradation rate was confirmed also for WE43 alloy, which is progressively depleted over the period of 12 months of implantation, resulting in improved osseointegration in part due to its moderate osteostimulative effect [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

“…For in vivo studies, the most used animal model was the rat (54%) [ 8 , 17 , 22 , 28 , 40 , 46 , 47 ], followed by the rabbit (31%) [ 16 , 25 , 45 , 50 ]; only two studies were carried out on a large animal model (minipig 15%) [ 48 , 49 ]. Regarding the implant site, the Mg alloy implants were inserted in femoral condyle (38%) [ 17 , 25 , 28 , 40 , 47 ], trochanter (23%) [ 22 , 45 , 50 ] or diaphysis (15%) [ 46 , 49 ], tibial metaphysis (15%) [ 8 , 16 ] and frontal bone (8%) [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

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Magnesium Alloys in Orthopedics: A Systematic Review on Approaches, Coatings and Strategies to Improve Biocompatibility, Osteogenic Properties and Osteointegration Capabilities

Giavaresi,

Bellavia,

De Luca

et al. 2023

IJMS

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There is increasing interest in using magnesium (Mg) alloy orthopedic devices because of their mechanical properties and bioresorption potential. Concerns related to their rapid degradation have been issued by developing biodegradable micro- and nanostructured coatings to enhance corrosion resistance and limit the release of hydrogen during degradation. This systematic review based on four databases (PubMed®, Embase, Web of Science™ and ScienceDirect®) aims to present state-of-the-art strategies, approaches and materials used to address the critical factors currently impeding the utilization of Mg alloy devices. Forty studies were selected according to PRISMA guidelines and specific PECO criteria. Risk of bias assessment was conducted using OHAT and SYRCLE tools for in vitro and in vivo studies, respectively. Despite limitations associated with identified bias, the review provides a comprehensive analysis of preclinical in vitro and in vivo studies focused on manufacturing and application of Mg alloys in orthopedics. This attests to the continuous evolution of research related to Mg alloy modifications (e.g., AZ91, LAE442 and WE43) and micro- and nanocoatings (e.g., MAO and MgF2), which are developed to improve the degradation rate required for long-term mechanical resistance to loading and excellent osseointegration with bone tissue, thereby promoting functional bone regeneration. Further research is required to deeply verify the safety and efficacy of Mg alloys.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Magnesium Alloys in Orthopedics: A Systematic Review on Approaches, Coatings and Strategies to Improve Biocompatibility, Osteogenic Properties and Osteointegration Capabilities

Giavaresi,

Bellavia,

De Luca

et al. 2023

IJMS

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“…Nevertheless, they present long degradation times (typically years) and low mechanical properties and generate acidic by-products during degradation that can lead to an inflammatory response of surrounding tissue [30] [90].…”

Section: Motivation and Objectivesmentioning

confidence: 99%

Bioabsorbable Composite Laminates of Poly‐Lactic Acid Reinforced with Surface‐Modified Mg Wires for Orthopedic Implant Applications

Ali,

González,

Kopp

et al. 2024

Adv Eng Mater

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Unidirectional and multidirectional laminates of Mg wire‐reinforced PLA‐matrix composites were manufactured by an improved compression molding strategy that allows excellent control on the position and orientation of the wires. Two different types of Mg wires, with and without surface modification by continuous plasma electrolytic oxidation were used, the former to improve the interfacial strength and to reduce the degradation rate of Mg wires in biological environments. The mechanical properties of the constituents as well as of composites were measured before and after degradation by immersion in simulated body fluids and the corresponding deformation, fracture and degradation mechanisms were analyzed in detail. It was found that the presence of the Mg wires improved the mechanical behavior in tension and compression of unidirectional composites in the longitudinal direction (close to cortical bone) and that quasi‐isotropic laminates with tailored properties could be designed from the data of unidirectional composites.This article is protected by copyright. All rights reserved.

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“…The rapid degradation rate of Mg and its alloys in aqueous environment is a bottleneck that hampers their extensive clinical applications. 52–54 The fast corrosion speed of Mg metal can be attributed to its high electrochemical activity. 55 Mg possesses a relatively low standard electrode potential of −2.37 V SHE , and, thus, it always acts as the anode and suffers corrosion in contact with other metals, 56 which is the major reason for its poor corrosion resistance.…”

Section: Introductionmentioning

confidence: 99%

Mg alloys with antitumor and anticorrosion properties for orthopedic oncology: A review from mechanisms to application strategies

Lin,

Wei,

Yang

2024

APL Bioengineering

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As a primary malignant bone cancer, osteosarcoma (OS) poses a great threat to human health and is still a huge challenge for clinicians. At present, surgical resection is the main treatment strategy for OS. However, surgical intervention will result in a large bone defect, and some tumor cells remaining around the excised bone tissue often lead to the recurrence and metastasis of OS. Biomedical Mg-based materials have been widely employed as orthopedic implants in bone defect reconstruction, and, especially, they can eradicate the residual OS cells due to the antitumor activities of their degradation products. Nevertheless, the fast corrosion rate of Mg alloys has greatly limited their application scope in the biomedical field, and the improvement of the corrosion resistance will impair the antitumor effects, which mainly arise from their rapid corrosion. Hence, it is vital to balance the corrosion resistance and the antitumor activities of Mg alloys. The presented review systematically discussed the potential antitumor mechanisms of three corrosion products of Mg alloys. Moreover, several strategies to simultaneously enhance the anticorrosion properties and antitumor effects of Mg alloys were also proposed.

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Long-term in vivo observations show biocompatibility and performance of ZX00 magnesium screws surface-modified by plasma-electrolytic oxidation in Göttingen miniature pigs

Cited by 18 publications

References 40 publications

Magnesium Alloys in Orthopedics: A Systematic Review on Approaches, Coatings and Strategies to Improve Biocompatibility, Osteogenic Properties and Osteointegration Capabilities

Magnesium Alloys in Orthopedics: A Systematic Review on Approaches, Coatings and Strategies to Improve Biocompatibility, Osteogenic Properties and Osteointegration Capabilities

Bioabsorbable Composite Laminates of Poly‐Lactic Acid Reinforced with Surface‐Modified Mg Wires for Orthopedic Implant Applications

Mg alloys with antitumor and anticorrosion properties for orthopedic oncology: A review from mechanisms to application strategies

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