Long-Term In Vivo Oxygen Sensors for Peripheral Artery Disease Monitoring

Nichols, Scott P.; Balaconis, Mary K.; Gant, Rebecca M; Au-Yeung, Kit Yee; Wisniewski, Natalie A.

doi:10.1007/978-3-319-91287-5_56

Cited by 9 publications

(6 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Needle-based electrochemical and optical sensors have been developed for in vivo applications [10,11]; while useful, these are still invasive, only usable for a short time, and during that time they are affected by the host response due to the tissue trauma and associated inflammatory/immune response at the site of measurement. In contrast, phosphorescent oxygen-sensing materials are particularly useful in long-term implantable metabolite sensors and can be used by incorporating them in a wide variety of materials [12][13][14]. The phosphorescent oxygen sensor exhibits phosphorescence quenching proportional to the oxygen concentration in the environment and metabolite sensors can be realized by combining these phosphorescent oxygen sensors with oxidase enzyme that consume oxygen during the oxidation of metabolites in the enzymatic reaction.…”

Section: Introductionmentioning

confidence: 99%

NIR Luminescent Oxygen-Sensing Nanoparticles for Continuous Glucose and Lactate Monitoring

et al. 2023

View full text Add to dashboard Cite

A highly sensitive, biocompatible, and scalable phosphorescent oxygen sensor formulation is designed and evaluated for use in continuous metabolite sensors for biological systems. Ethyl cellulose (EC) and polystyrene (PS) nanoparticles (NPs) stabilized with Pluronic F68 (PF 68), Polydimethylsiloxane-b-polyethyleneglycol methyl ether (PDMS-PEG), sodium dodecylsulfate (SDS), and cetyltimethylammonium bromide (CTAB) were prepared and studied. The resulting NPs with eight different surfactant–polymer matrix combinations were evaluated for physical properties, oxygen sensitivity, effect of changes in dispersion matrix, and cytotoxicity. The EC NPs exhibited a narrower size distribution and 40% higher sensitivity than PS, with Stern–Volmer constants (Ksv) 0.041–0.052 µM−1 for EC, compared to 0.029–0.034 µM−1 for PS. Notably, ethyl cellulose NPs protected with PF68 were selected as the preferred formulation, as they were not cytotoxic towards 3T3 fibroblasts and exhibited a wide phosphorescence lifetime response of >211.1 µs over 258–0 µM and ~100 µs over 2.58–0 µM oxygen, with a limit of detection (LoD) of oxygen in aqueous phase of 0.0016 µM. The EC-PF68 NPs were then efficiently encapsulated in alginate microparticles along with glucose oxidase (GOx) and catalase (CAT) to form phosphorescent nanoparticles-in-microparticle (NIMs) glucose sensing microdomains. The fabricated glucose sensors showed a sensitivity of 0.40 µs dL mg−1 with a dynamic phosphorescence lifetime range of 46.6–197.1 µs over 0–150 mg dL−1 glucose, with a glucose LoD of 18.3 mg dL−1 and maximum distinguishable concentration of 111.1 mg dL−1. Similarly, lactate sensors were prepared with NIMs microdomains containing lactate oxidase (LOx) and found to have a detection range of 0–14 mg dL−1 with LoD of 1.8 mg dL−1 and maximum concentration of 13.7 mg dL−1 with lactate sensitivity of 10.7 µs dL mg−1. Owing to its versatility, the proposed NIMs-based design can be extended to a wide range of metabolites and different oxygen-sensing dyes with different excitation wavelengths based on specific application.

show abstract

Section: Introductionmentioning

confidence: 99%

NIR Luminescent Oxygen-Sensing Nanoparticles for Continuous Glucose and Lactate Monitoring

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Multiple studies have shown the direct correlation between pH and lactate, e.g. Atkins et al [17] and Nichols et al [18]. Most research on pH sensing in the body is in the field of blood measurements, since this would make the blood gas analysers and blood tests redundant.…”

Section: Detection Of Ischaemia By Ph Measurementmentioning

confidence: 99%

Opto-Chemical pH Detection of Myocardial Ischaemia Using Fluorescent Hydrogels

et al. 2022

View full text Add to dashboard Cite

“…Here, such sensors can provide data for remote follow-up and allow for greater time between physical visits. For instance, the "Lumee" biosensor allows for long-term monitoring of tissue oxygen levels, helping in the follow-up of peripheral vascular disease, which tends to also be neglected in rural areas (43).…”

Section: The Case For More For Lessmentioning

confidence: 99%

Delivering High-Quality, Equitable Care in India: An Ethically-Resilient Framework for Healthcare Innovation After COVID-19

Ozair

Singh

2021

Front. Public Health

View full text Add to dashboard Cite

Developing countries struggle to provide high-quality, equitable care to all. Challenges of resource allocation frequently lead to ethical concerns of healthcare inequity. To tackle this, such developing nations continually need to implement healthcare innovation, coupled with capacity building to ensure new strategies continue to be developed and executed. The COVID-19 pandemic has made significant demands of healthcare systems across the world—to provide equitable healthcare to all, to ensure public health principles are followed, to find novel solutions for previously unencountered healthcare challenges, and to rapidly develop new therapeutics and vaccines for COVID-19. Countries worldwide have struggled to accomplish these demands, especially the latter two, considering that few nations had long-standing systems in place to ensure processes for innovation were on-going before the pandemic struck. The crisis represents a critical juncture to plan for a future. This future needs to incorporate a vision for the implementation of healthcare innovation, coupled with capacity building to ensure new strategies continue to be developed and executed. In this paper, the case of the massive Indian healthcare system is utilized to describe how it could implement this vision. An inclusive, ethically-resilient framework has been broadly laid out for healthcare innovation in the future, thereby ensuring success in both the short- and the long-term.

show abstract

Long-Term In Vivo Oxygen Sensors for Peripheral Artery Disease Monitoring

Cited by 9 publications

References 11 publications

NIR Luminescent Oxygen-Sensing Nanoparticles for Continuous Glucose and Lactate Monitoring

NIR Luminescent Oxygen-Sensing Nanoparticles for Continuous Glucose and Lactate Monitoring

Opto-Chemical pH Detection of Myocardial Ischaemia Using Fluorescent Hydrogels

Delivering High-Quality, Equitable Care in India: An Ethically-Resilient Framework for Healthcare Innovation After COVID-19

Contact Info

Product

Resources

About