Long-term Incidence of Kawasaki Disease in a North American Community: A Population-Based Study

Taslakian, Editt N.; Wi, Chung Il; Seol, Hee Yun; Boyce, Thomas G.; Johnson, Jonathan N.; Ryu, Euijung; King, Katherine S.; Juhn, Young J.; 최봉석,

doi:10.1007/s00246-021-02577-2

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…Indeed, 73.50% of the cases included in this review were males. This is in accordance with previous research, which showed that KD is more common in boys, with a male:female ratio of about 1.6:1 [105,106]. Furthermore, according to Nakamura et al, males suffering from cardiac complications caused by KD experience a higher mortality rate in comparison to the general population, whereas the mortality rates for females with complications and for both males and females without complications were not increased [94].…”

Section: Discussionsupporting

confidence: 91%

Autoptic Findings in Cases of Sudden Death Due to Kawasaki Disease

et al. 2023

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Kawasaki disease (KD) is the second-most-common childhood vasculitis, and its etiology is still unknown today. Even though the acute illness is usually self-limiting, sometimes, it can generate complications, such as coronary artery aneurysms (CAA), acute myocardial infarction (AMI), heart failure, or arrhythmias, and can rarely cause sudden or unexpected deaths. We present a review of the literature, which collects autoptic and histopathological data relating to many of the cases of these deaths. On the basis of the titles and abstracts, we selected 54 scientific publications for a total of 117 cases. Among them, as expected, the majority of the deaths were due to AMI (41.03%), arrhythmia (8.55%), acute coronary syndrome (8.55%), and CAA rupture (11.97%), involving mostly 20-year-olds or younger individuls (69.23%). This is not surprising since the CAs are the most involved arteries. Gross autoptic and histopathological findings are reported in the paper. Our work revealed that, when compared with the incidence of KD, only a few cases suffered from sudden death, underwent an autoptic examination, and were then described in the literature. We suggest that researchers should perform autopsies to gain a better understanding of the molecular pathways involved in KD so as to propose further innovative therapeutic protocols or implement more appropriate prevention schemes.

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Section: Discussionsupporting

confidence: 91%

Autoptic Findings in Cases of Sudden Death Due to Kawasaki Disease

et al. 2023

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“…The prevalence of suspected antecedent KD in young adults with suspected ACS is 5% and 7.4% according to Daniels et al and the present study (Table 3), respectively. Given its occurrence in genetically susceptible individuals (18), KD is more prevalent in children younger than 5 years old of the present cohort [20 (19) vs. 80 (4) per million children <5 years old]; however, the prevalence difference of antecedent KD is smaller than expected. This may be due to a multi-factor phenomenon, including genetic diversity, medical source accessibility, diet habits, and self-health management awareness (20).…”

Section: Different Incidence Different Prevalencementioning

confidence: 77%

Prevalence of antecedent Kawasaki disease in young adults with suspected acute coronary syndrome in high incidence cohort

Shyu

et al. 2023

Front. Cardiovasc. Med.

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BackgroundAcute coronary syndrome (ACS) in early adulthood (<40 years old) may be associated with unrevealed diagnoses of Kawasaki disease (KD) in childhood. Daniels et al. showed that 5% of young adults with acute coronary syndrome might have antecedent Kawasaki disease in a cohort with Kawasaki disease incidence rates ranging from about 9 to 20 per 100,000 children under 5 years of age. However, there is no relevant research from the cohort with higher incidence rates (>80–100 per 100,000 children under 5 years of age) of Kawasaki disease.MethodsWe conducted a multicenter, retrospective study by reviewing medical records and angiographic data from two institutions (middle and southern Taiwan, respectively) of adults <40 years of age who underwent coronary angiography for clinically suspected acute coronary syndrome (2009–2019). Angiographic images were independently analyzed by three cardiologists who were blinded to the medical records. Demographic and laboratory data and risk factors of coronary artery disease were integrated to assess the likelihood of antecedent KD.ResultsAll 323 young adults underwent coronary angiography, and 27 had coronary aneurysms. The patients’ clinical and angiographic characteristics were evaluated, and 7.4% had aneurysms likely to be associated with KD. Most subjects were male (23/24), and their low-density lipoprotein (LDL) levels were significantly higher (p = 0.028) than those of subjects unlikely to have KD.ConclusionThis study proposed that the cohort with higher Kawasaki disease incidence rates may have a higher prevalence of young adult ACS associated with antecedent KD. The importance of determining the clinical therapeutic significance of antecedent Kawasaki disease in young adult ACS warrants advanced research. Higher LDL levels may have a long-term cardiovascular impact in KD patients with persistent coronary aneurysms.

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Trends and Resource Utilization in Kawasaki Disease Hospitalizations in the United States, 2008–2017

Vasudeva

Poku

Thommana

et al. 2022

Hospital Pediatrics

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OBJECTIVES: To explore trends in hospitalization rate, resource use, and outcomes of Kawasaki Disease (KD) in children in the United States from 2008 to 2017. METHODS: This was a retrospective, serial cross-sectional analysis of pediatric hospitalizations with International Classification of Disease diagnostic codes for KD in the National Inpatient Sample. Hospitalization rates per 100 000 populations were calculated and stratified by age group, gender, race, and US census region. Prevalence of coronary artery aneurysms (CAA) were expressed as proportions of KD hospitalizations. Resource use was defined in terms of length of stay and hospital cost. Cochran-Armitage and Jonckheere-Terpstra trend tests were used for categorical and continuous variables, respectively. P <.05 was considered significant. RESULTS: A total of 43 028 pediatric hospitalizations identified with KD, yielding an overall hospitalization rate of 5.5 per 100 000 children. The overall KD hospitalization rate remained stable over the study period (P = .18). Although KD hospitalization rates differed by age group, gender, race, and census region, a significant increase was observed among Native Americans (P = .048). Rates of CAA among KD hospitalization increased from 2.4% to 6.8% (P = .04). Length of stay remained stable at 2 to 3 days, but inflation-adjusted hospital cost increased from $6819 in 2008 to $10 061 in 2017 (Ptrend < 0.001). CONCLUSIONS: Hospitalization-associated costs and rates of CAA diagnostic codes among KD hospitalizations increased, despite a stable KD hospitalization rate between 2008 and 2017. These findings warrant further investigation and confirmation with databases with granular clinical information.

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Long-term Incidence of Kawasaki Disease in a North American Community: A Population-Based Study

Cited by 3 publications

References 25 publications

Autoptic Findings in Cases of Sudden Death Due to Kawasaki Disease

Autoptic Findings in Cases of Sudden Death Due to Kawasaki Disease

Prevalence of antecedent Kawasaki disease in young adults with suspected acute coronary syndrome in high incidence cohort

Trends and Resource Utilization in Kawasaki Disease Hospitalizations in the United States, 2008–2017

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