Long-Term Influence of Prepubertal Testicular Torsion on Spermatogenesis

Sun, Jie; Liu, Guohua; Zhao, Haiteng; Shi, Cheng-ren

doi:10.1159/000094822

Cited by 12 publications

(8 citation statements)

References 34 publications

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“…TT is a relatively rare urological emergency, most commonly encountered in vulnerable children and adolescents. Torsion of the left testicle is more common than the right one, [6][7][8][9] consistent with findings in the present study. Some abnormalities that occur during development of the male reproductive system have reportedly been associated with TT morbidity.…”

Section: Discussionsupporting

confidence: 92%

Effect of unilateral testicular torsion at different ages on male fertility

Zhang

Cai

et al. 2020

J Int Med Res

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Objective To investigate the effect of early-life unilateral testicular torsion on adult male fertility. Methods Clinical information was collected for 122 patients who had experienced unilateral testicular torsion at a median age of 15.5 years. The recent pregnancy rate and time to pregnancy experienced by the patients’ female partners were assessed by structured interviews. Data were analyzed by the chi-squared test and Student’s t-test. Results Seventy-two patients with testicular torsion met the criteria for inclusion in our analyses; 49 had undergone orchiectomy, while 23 had undergone surgical repositioning/orchiopexy. The pregnancy rate and median time to pregnancy were 83.67% (41/49) and 1.6 years, respectively, in the orchiectomy group, whereas they were 91.30% (21/23) and 0.75 years, respectively, in the repositioning/orchiopexy group. The recent pregnancy rate was higher in patients with torsion in childhood than in patients with torsion in adolescence; it was lowest in patients with torsion in adulthood. Surgical repositioning/orchiopexy yielded a significantly better recent pregnancy rate among the three groups, based on age at the time of torsion, and a shorter time to pregnancy than orchiectomy in patients with torsion in adolescence. Conclusion Onset of unilateral testicular torsion early in life has a negligible effect on adult male fertility.

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Section: Discussionsupporting

confidence: 92%

Effect of unilateral testicular torsion at different ages on male fertility

Zhang

Cai

et al. 2020

J Int Med Res

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“…It was shown that testicular torsion definitely caused testicular damage and this damage was related to the duration of torsion [7,8,9]. Most of the studies evaluated the effect of testicular torsion on spermatogenesis.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Testicular Torsion Duration on Testicular Steroidogenesis in the Rat Model

Kurt¹,

Yazıcı²,

Gevher³

et al. 2016

Urol Int

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Background: Testicular torsion is an emergency condition in which spermatogenesis may be irreversibly damaged. There have been controversial results about the effect of testicular torsion on steroidogenesis. We aimed at investigating the effect of testicular torsion on steroidogenesis. Material and Methods: A total of 40 adult male rats were divided into 4 groups. Left testicles were removed in all groups. Right testicles were torsioned and remained in the torsion position for 1, 3 and 5 h in study groups, whereas no torsion was performed in control. Serum luteinizing hormone (LH) and total testosterone (TT) levels were measured on the 3rd and 30th days of surgery and orchiectomy was performed on the 30th day of testicular torsion for histopathological evaluation. Results: TT levels of study groups were significantly lower than that of the control group on the 3rd day of torsion. LH of study groups was higher than that of the control group, but the difference was significant only in the 5 h-torsion group. The total number of Leydig cells increased in 1- and 3-h groups, whereas it decreased in the 5-hour group. Conclusion: Testosterone production and Leydig cell functions significantly decreased after 5 h torsion in the rat model. The duration of torsion less than 5 h yielded partial dysfunction on steroidogenesis.

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“…There are few experimental studies in the literature in regard to the long-term effects of testicular torsion on the spermatogenesis of the contralateral testis, and the value of the orchiepididymectomy of the twisted testis to prevent them [10][11][12][13][14][15] . Using unilateral testicular torsion of 720 degrees in adult rats for one, two or four hours, Turner 10 observed no injury to the contralateral spermatogenesis testis after seven, 30 and 60 days, evaluating its testis weight, spermatogenesis status only subjectively classified as normal or abnormal and the concentration and motility of the spermatozoids in the tail of the epididymis.…”

Section: Discussionmentioning

confidence: 99%

“…However, there are few and conflicting results in the literature as to whether the testicular torsion causes permanent damage (long-term effects) to the spermatogenesis of the contralateral testis, and whether the orchiepididymectomy of the twisted testis could prevent this damage [10][11][12][13][14][15] . Many theories have been suggested to explain the contralateral injuries to the spermatogenesis, such as auto-immunization induced by the necrotic haploid germ cells of the twisted testis 16 , production of reactive oxygen species 11,14 and contralateral sympathetic reflex 13 .…”

Section: Introductionmentioning

confidence: 99%

Long-term effects of the testicular torsion on the spermatogenesis of the contralateral testis and the preventive value of the twisted testis orchiepididymectomy

Lorenzini

Filho

Gomes³

et al. 2012

Acta Cir. Bras.

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-ORIGINAL ARTICLE EXPERIMENTAL UROLOGYLong-term effects of the testicular torsion on the spermatogenesis of the contralateral testis and the preventive value of the twisted testis orchiepididymectomy 1 Efeitos tardios da torção testicular sobre a espermatogênese do testículo contralateral e o valor preventivo da orquiepididimectomia do testículo torcido ABSTRACT PURPOSE: To determine whether the testicular torsion causes long-term effects on the spermatogenesis of the contralateral testis, and whether the orchiepididymectomy of the twisted testis could prevent them, using specific spermatogenesis parameters to elucidate the conflicting results in the literature. METHODS: Seventy-four pubertal male Wistar rats were randomly selected. The experimental group consisted of 40 rats, divided into four subgroups, submitted to 1.080 degrees counterclockwise left testicular torsion and its scrotal fixation at the beginning of the experiment, and left orchiepididymectomy at one, five, ten and 90 days, respectively. The control group consisted of 24 rats, divided into four sham operation control subgroups. An additional control subgroup consisted of the ten remaining rats, submitted only to the left orchiepididymectomy at the beginning. At 90 days, the contralateral testes of the experimental and control subgroups were collected for the evaluation of their spermatogenesis parameters: testicular weight, seminiferous tubular diameter, Johnsen score and differential counting of the germ cells. RESULTS:No statistically significant differences were observed among the experimental and control subgroups for all of the spermatogenesis parameters of the contralateral testes. CONCLUSIONS: Testicular torsion does not cause long-term effects on the spermatogenesis of the contralateral testis in pubertal rats, and the orchiepididymectomy of the twisted testis is not necessary for preventive purposes for the contralateral spermatogenesis. Key words: Spermatic Cord Torsion. Spermatogenesis. Testis. Rats. RESUMO OBJETIVO:Determinar se a torção testicular causa efeitos tardios sobre a espermatogênese do testículo contralateral e se a orquiepididimectomia do testículo torcido poderia preveni-los, usando parâmetros específicos da espermatogênese para elucidar os resultados conflitantes na literatura. MÉTODOS: Foram selecionados aleatoriamente 74 ratos machos púberes da linhagem Wistar. O grupo experimental foi composto por 40 ratos divididos em quatro subgrupos, submetidos à torção anti-horária de 1,080 graus do testículo esquerdo e sua fixação escrotal no início do experimento e à orquiepidimectomia esquerda com um, cinco, dez e 90 dias, respectivamente. O grupo controle foi composto por 24 ratos divididos em quatro subgrupos de cirurgias simuladas. Um subgrupo controle adicional foi constituído pelos dez ratos restantes submetidos unicamente à orquiepididimectomia esquerda no início do experimento. Aos 90 dias, os testículos contralaterais dos subgrupos experimentais e controles foram coletados para avaliação dos parâmetros de suas espermat...

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Long-Term Influence of Prepubertal Testicular Torsion on Spermatogenesis

Cited by 12 publications

References 34 publications

Effect of unilateral testicular torsion at different ages on male fertility

Effect of unilateral testicular torsion at different ages on male fertility

The Effect of Testicular Torsion Duration on Testicular Steroidogenesis in the Rat Model

Long-term effects of the testicular torsion on the spermatogenesis of the contralateral testis and the preventive value of the twisted testis orchiepididymectomy

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