Long-term inhibition of dipeptidyl-peptidase 4 reduces islet infiltration and downregulates IL-1β and IL-12 in NOD mice

He, Xianghui; Li, Wangen; Xie, Yunliang; Zhao, Yunjuan

doi:10.1016/j.intimp.2020.106945

Cited by 6 publications

(1 citation statement)

References 41 publications

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“…Moreover, DPP4 gene deletion caused increased T cell proliferation and type 1 cytokine production in mice [ 27 ]. In NOD mice, long-term inhibition of DPP-4 decreased the infiltration of CD4 + T cells in islets, alleviated insulitis and reduced serum levels of IL-1β and IL-12 [ 28 ]. When comparing the results from human and mice, it is important to consider that DPP4 expression in blood is different between humans and mice.…”

Section: Discussionmentioning

confidence: 99%

The serum concentration and activity of DPP4 is positively related with the severity of hyperthyroidism in patients with Graves’ disease

et al. 2023

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Objective Graves’ disease (GD) is an organ-specific autoimmune disease. The production of anti-thyrotropin receptor antibodies (TRAb) is associated with a loss of immune tolerance. Dipeptidyl peptidase-4 (DPP-4) is expressed on multiple immune cells. This study aimed to investigate the relationship between serum concentration/activity of DPP4 and the severity of hyperthyroidism in GD patients. Methods A total of 82 newly diagnosed drug-naive patients with GD hyperthyroidism, 20 patients with non-autoimmune thyrotoxicosis and 122 age- and sex- matched healthy controls were enrolled. The clinical parameters and serum concentration and activity of DPP4 were measured. Results The GD group had increased serum concentration and activity of DPP4 than the healthy controls and patients with non-autoimmune thyrotoxicosis, while no significant difference was observed in the latter two groups. Multivariate linear regression indicated that the serum concentration/activity of DPP4 were positively associated with FT3, FT4 and TRAb levels in the GD patients. And the positive association between serum concentration/activity of DPP4 and TRAb was remained even after adjustment for confounding factors (all p < 0.05). Conclusions The GD patients had significantly increased serum concentration/activity of DPP4. And the serum concentration/activity of DPP4 was positively associated with the severity of hyperthyroidism in GD patients. Key messages The activity and concentration of DPP4 in patients with Graves’ disease were higher than those in healthy controls. There was a significant positive correlation between serum DPP4 concentration and TRAb levels in patients with Graves’ disease. In patients with Graves ‘disease, serum DPP4 activity was positively correlated with TRAb levels.

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Section: Discussionmentioning

confidence: 99%

The serum concentration and activity of DPP4 is positively related with the severity of hyperthyroidism in patients with Graves’ disease

et al. 2023

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Roseburia intestinalis‐derived extracellular vesicles ameliorate colitis by modulating intestinal barrier, microbiome, and inflammatory responses

Han,

Hwang,

Choi

et al. 2024

J of Extracellular Vesicle

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Inflammatory bowel disease (IBD) is a chronic disorder characterized by recurrent gastrointestinal inflammation, lacking a precise aetiology and definitive cure. The gut microbiome is vital in preventing and treating IBD due to its various physiological functions. In the interplay between the gut microbiome and human health, extracellular vesicles secreted by gut bacteria (BEVs) are key mediators. Herein, we explore the role of Roseburia intestinalis (R)‐derived EVs (R‐EVs) as potent anti‐inflammatory mediators in treating dextran sulfate sodium‐induced colitis. R was selected as an optimal BEV producer for IBD treatment through ANCOM analysis. R‐EVs with a 76 nm diameter were isolated from R using a tangential flow filtration system. Orally administered R‐EVs effectively accumulated in inflamed colonic tissues and increased the abundance of Bifidobacterium on microbial changes, inhibiting colonic inflammation and prompting intestinal recovery. Due to the presence of Ile‐Pro‐Ile in the vesicular structure, R‐EVs reduced the DPP4 activity in inflamed colonic tissue and increased the active GLP‐1, thereby downregulating the NFκB and STAT3 via the PI3K pathway. Our results shed light on the impact of BEVs on intestinal recovery and gut microbiome alteration in treating IBD.

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Arachidonic acid alleviates autoimmune diabetes in NOD mice

Zhao,

Chen,

Xiao

et al. 2024

International Immunopharmacology

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Long-term inhibition of dipeptidyl-peptidase 4 reduces islet infiltration and downregulates IL-1β and IL-12 in NOD mice

Abstract: Highlight: DPP-4 inhibition reduced CD4+T cells infiltration and ameliorated insulitis. DPP-4 inhibition downregulated serum IL-1β and IL-12. LPS increased CD11b+ cells to infiltrate into islets.

Cited by 6 publications

References 41 publications

The serum concentration and activity of DPP4 is positively related with the severity of hyperthyroidism in patients with Graves’ disease

The serum concentration and activity of DPP4 is positively related with the severity of hyperthyroidism in patients with Graves’ disease

Roseburia intestinalis‐derived extracellular vesicles ameliorate colitis by modulating intestinal barrier, microbiome, and inflammatory responses

Arachidonic acid alleviates autoimmune diabetes in NOD mice

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