Long-term low-dose exposure of permethrin induces liver and kidney damage in rats

Sun, Ying-Jian; Liang, Yujie; Lin, Yang; Long, Dongyang; Wang, Huiping; Wu, Yi‐Jun

doi:10.1186/s40360-022-00586-2

Cited by 11 publications

(5 citation statements)

References 29 publications

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“…This study concurs with the findings of Danaei et al [21] regarding the effect of diazinon on the liver and kidneys of rodents. In addition to what was observed in the case study, similar changes in heterotrophy, degeneration, and swelling were observed in Sun et al [22] investigation on the effect of permethrin on rat liver cells and kidneys.…”

Section: Resultssupporting

confidence: 87%

Effect of Sub Lethal Dose of Pyrethroids Insecticide on Hepatocyte of Female Albino Mice

Ali¹,

Zain²

2023

IJDNE

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Agricultural pesticides play an important and pivotal role in agricultural production processes in all their stages, and the superior success shown by agricultural pesticides in controlling agricultural pests has led to greater dependence on them. Pesticides accumulate in the food chain and the human environment over time in both cases, including the overuse or misuse of many of them in various fields at times. However, they are also used to treat agricultural biting and sucking insects. The current paper aims to investigate the effect of a sub lethal dose of pyrethiored insecticide on the hepatocytes of male albino mice. Based on the current results, the hepatocyte structure and tissues section clarify the effect of Permethrin insecticide, including changes such as necrosis, venous hypertrophy, and increased vacuoles. The hepatic portal and vacuoles show vacuolar degeneration, which means that the changes are severe and an indication of the toxicity of insecticide, and this difference appears to be significant compared to the control.

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Section: Resultssupporting

confidence: 87%

Effect of Sub Lethal Dose of Pyrethroids Insecticide on Hepatocyte of Female Albino Mice

Ali¹,

Zain²

2023

IJDNE

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“…Similar results were observed when rats were treated with 50 mg.kg -1 b.wt. of cypermethrin orally for six weeks [8].…”

Section: Hematological Parametersmentioning

confidence: 99%

“…Toxicity of insecticides in man, animal and aquatic organism may occur through oral, inhalation and dermal route. Many oral/dermal toxicity studies have been performed for different pyrethroids insecticides in the past by different scientists [5][6][7][8]. Nevertheless, the impact of repeated dermal exposure to permethrin on hemato-biochemistry has not been conducted yet.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Permethrin Toxicity Following Subacute Dermal Exposure in Rats

Patel,

Dewangan,

Rajput

et al. 2024

JSRR

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Permethrin is an insecticide in the pyrethroid family, used for control of pests in veterinary and agriculture sector. Present study was planned to evaluate the toxicity of permethrin following daily dermal application in Albino rats for 28 days. Thirty six rats were divided in to three groups, each group containing six animals. Group I was treated as control and rats in groups II and III were dermally exposed to permethrin at dose 100 and 200 mg.kg-1 b.wt., respectively daily for 28 days. Hematological and biochemical parameters were assessed at 0, 14th and 28th day of exposure. Significant changes in level of haemoglobin, total erythrocyte count and packed cell volume was observed at both the doses of permethrin during exposure period. The present investigation also resulted in significant elevation in aspartate amino transaminase, alanine amino transaminase, alkaline phosphatase, lactate dehydrogenase activities and significant increase in blood urea nitrogen and creatinine level in permethrin treated rats at both dose levels which indicated liver and kidney. Present study suggests that permethrin may be harmful when repeated dermal exposure occurs.

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“…Permethrin exposure disrupts the balance of the antioxidant system in non-target organisms and causes oxidative damage to DNA, lipids, and proteins (Weidinger and Kozlov 2015 ). Sun et al ( 2022 ) reported that long-term and low-dose exposure to permethrin caused liver and kidney damages in non-target rats. Davoodi et al ( 2012 ) found that high mortality rates were observed in juvenile Cyprinus carpio treated with permethrin in the dose range of 10–125 mg/L.…”

Section: Introductionmentioning

confidence: 99%

In-vivo and in-silico studies to identify toxicity mechanisms of permethrin with the toxicity-reducing role of ginger

Himtaş,

Yalçin,

Çavuşoğlu

et al. 2024

Environ Sci Pollut Res

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In this study, the toxic effects of permethrin on Allium cepa L. and the protective role of Zingiber officinale rhizome extract (Zoex) were investigated. In this context, 6 different groups were formed. While the control group was treated with tap water, the groups II and III were treated with 10 µg/mL and 20 µg/mL Zoex, respectively, and the group IV was treated with 100 µg/L permethrin. The protective effect of Zoex against permethrin toxicity was studied as a function of dose, and groups V and VI formed for this purpose were treated with 10 µg/mL Zoex + 100 µg/L permethrin and 20 µg/mL Zoex + 100 µg/L permethrin, respectively. After 72 h of germination, cytogenetic, biochemical, physiological, and anatomical changes in meristematic cells of A. cepa were studied. As a result, permethrin application decreased the mitotic index (MI) and increased the frequency of micronuclei (MN), and chromosomal abnormalities. The increase in malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) and the decrease in glutathione (GSH) indicate that permethrin causes oxidative damage. Compared to the control group, a 68.5% decrease in root elongation (p < 0.05) and an 81.8% decrease (p < 0.05) in weight gain were observed in the permethrin-treated group. It was found that the application of Zoex together with permethrin resulted in regression of all detected abnormalities, reduction in the incidence of anatomical damage, MN and chromosomal aberrations, and improvement in MI rates. The most significant improvement was observed in group VI treated with 20 µg/mL Zoex, and Zoex was also found to provide dose-dependent protection. The toxicity mechanism of permethrin was also elucidated by molecular docking and spectral studies. From the data obtained during the study, it was found that permethrin has toxic effects on A. cepa, a non-target organism, while Zoex plays a protective role by reducing these effects.

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Long-term low-dose exposure of permethrin induces liver and kidney damage in rats

Cited by 11 publications

References 29 publications

Effect of Sub Lethal Dose of Pyrethroids Insecticide on Hepatocyte of Female Albino Mice

Effect of Sub Lethal Dose of Pyrethroids Insecticide on Hepatocyte of Female Albino Mice

Assessment of Permethrin Toxicity Following Subacute Dermal Exposure in Rats

In-vivo and in-silico studies to identify toxicity mechanisms of permethrin with the toxicity-reducing role of ginger

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