Long-Term Multimodal Therapy (Verapamil Associated with Propolis, Blueberry, Vitamin E and Local Diclofenac) on Patients with Peyronie's Disease (Chronic Inflammation of the Tunica Albuginea). Results of a Controlled Study

Paulis, Gianni; Cavallini, Giorgio; Giorgio, Giovanni De; Quattrocchi, Salvatore; Brancato, Tommaso; Alvaro, Rosaria

doi:10.2174/1871528112666131205112432

Cited by 34 publications

(23 citation statements)

References 32 publications

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“…A previous job shows that the anthocyanins isolated from bilberries and black currants, can prevent and treat chronic inflammatory diseases by inhibiting NF-kappaB transactivation and decreasing the concentrations of pro-inflammatory chemokines and cytokines (Karlsen et al 2007). On the other hand, blueberries have been already successfully used (combination therapy) in other chronic inflammatory diseases, such as Peyronie's disease (PD) (Paulis et al 2012(Paulis et al , 2013: a long-term combination therapy with blueberries is the best treatment for PD.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, it is necessary to push the work forward using these criteria. Blueberry, a kind of small fruits with fewer side effects, may have perfect health effects on JIA due to its anti-inflammatory activities (Paulis et al 2013;Johnson et al 2013;Esposito et al 2014). However, the role of blueberry for JIA therapy remains unknown, and the therapeutic effects are still needed to be determined.…”

Section: Introductionmentioning

confidence: 99%

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Blueberry Improves the Therapeutic Effect of Etanercept on Patients with Juvenile Idiopathic Arthritis: Phase III Study

Zhong

Wang

Guo

et al. 2015

Tohoku J. Exp. Med.

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Juvenile idiopathic arthritis (JIA) is the most common arthritis in the adolescents under the age of 16. Etanercept, an inhibitor of tumor necrosis factor, is often used to treat JIA despite its significant side effects. Homeopathic remedies, such as blueberries, have anti-inflammatory properties with fewer unwanted effects and should be considered as a primary treatment. We aimed to explore the efficacy and safety of combination therapy of blueberry and etanercept for JIA. Two hundred and one JIA patients were selected, and randomly and evenly assigned to three groups: ETA (50 mg of etanercept twice weekly), ETABJ (matched etanercept and 50 ml blueberry juice daily) and ETAPJ (matched etanercept and placebo juice). The severity of JIA was measured using American College of Rheumatology scales (ACR) 20, 50 and 70. The levels of pro-inflammatory cytokines, interleukin-1 (IL1) alpha and IL1 beta, and interleukin-1 receptor antagonist (IL1RA) were measured by qRT-PCR and ELISA. After a 6-month follow-up, the ACR20, ACR50 and ACR70 in an ETABJ group were higher than those in other two groups (P < 0.05), suggesting clinically meaningful improvement in JIA. Meanwhile, the symptoms and side effects were reduced significantly or absent in an ETABJ group, including mental diseases, retrobulbar optic neuritis, gaining weight, infection, cutaneous vasculitis, diarrhea, uveitis and pancytopenia. Blueberries reduced the levels of IL1 alpha and beta, and increased the level of IL1RA. Thus, a combination therapy of blueberry and etanercept can reduce the severity of JIA and should be developed as a new method for JIA therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Blueberry Improves the Therapeutic Effect of Etanercept on Patients with Juvenile Idiopathic Arthritis: Phase III Study

Zhong

Wang

Guo

et al. 2015

Tohoku J. Exp. Med.

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“…The theoretical benefit of blueberry juice as a salvage therapy is associated with the anti-inflammation capacity (30,31) and ability to prevent the progression of various types of cancer (32,33). However, the molecular mechanism of the inhibition of OC by blueberries remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Blueberries inhibit cyclooxygenase-1 and cyclooxygenase-2 activity in human epithelial ovarian cancer

Lin

2017

Oncology Letters

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Abstract. Ovarian cancer (OC) is the sixth and eighth leading cause of cancer mortality among women in developed and developing countries, respectively. Medical therapy is the main method for the treatment of OC. However, drug toxicity and the marked side effects of chemotherapy limit the usage and therapeutic results of the treatments. Therefore, the identification of multi-target agents with few side effects and high effectiveness is required. Traditional Chinese medicine has been used clinically to treat various types of cancer for thousands of years and is considered to possess multiple components and agents, which exert efficient therapeutic functions with few side effects. Although blueberries have previously been used to treat various types of cancer, the effect on OC and precise molecular mechanism of function of the fruit remains unknown. Cyclooxygenase (COX)-1 and COX-2 have been reported to be the biomarkers of OC. Blueberries may affect the progression of OC by affecting COX levels. To investigate the issue, COX-1 and COX-2 were overexpressed or silenced in ovarian cancer SKOV3 cells. The effect of blueberries on SKOV3 cell viability was determined by an MTT assay. Furthermore, a mouse model for OC was established. The results indicated that blueberries inhibited the proliferation of OC cells by downregulating the levels of COX-1 and COX-2. Blueberry (400 mg daily) consumption reduced tumor size significantly in mice with OC compared with the control without blueberry treatment (P<0.05). The results suggest that blueberries should be used to develop a potential non-pharmaceutical therapy for OC.

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“…Several studies have evaluated the effectiveness of the mentioned antioxidants in the treatment of PD [17,[22][23][24][47][48][49][50]. The properties of NSAID's, including the anti-inflammatory activity of Diclofenac, are already known, and it has been already used in the multimodal treatment of PD [17,22,24]. The significant improvements obtained in group A and B concern the basic parameters of the disease: plaque size, degree of penile curvature and penile rigidity (if erectile dysfunction was present).…”

Section: Discussionmentioning

confidence: 99%

“…Nonsurgical treatments include: potaba, Vitamin E, colchicine, tamoxifen, propolis, verapamil, interferons, collagenase, cortisone, pentoxifylline, iloprost, iontophoresi, Extracorporeal Shock Wave Therapy (ESWT) and Capacitive Resistive Energy Transfer (Tcare or TECAR therapy) [15][16][17][18][19][20][21]. Since we have already experienced the effectiveness of conservative treatment in the early phase of PD [17,[22][23][24], we implemented a controlled study on patients with PD treated in association with several drugs: Pentoxifylline plus several antioxidants (Vitamin E, blueberries and propolis) and topical Diclofenac.…”

Section: Introductionmentioning

confidence: 99%

Pentoxifylline Associated with Other Antioxidants (Multimodal Therapy) on Patients with Peyronie's Disease. Results of a Controlled Study

Paulis¹,

Farina²,

Cavallini³

et al. 2014

Andrology(Los Angel)

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Objective: The study was made mainly to investigate the possible benefits of multimodal treatment using Pentoxifylline (PTX) with other antioxidants, in patients with PD enrolled for a conservative medical management. Methods: We carried out a controlled study on 240 patients diagnosed with Peyronie's Disease (PD). We have divided two treatment groups, which differ from each other only for the association with PTX-penile injection. Two groups (A and B) were totally composed by 160 PD patients (80 patients for each group): Group A=PTX injection (penile and peri-lesional) 100 mg, every two weeks for six months + PTX 400 mg /oral/ twice daily + propolis 600 mg / oral / daily + blueberries 160 mg /oral/ daily + Vitamin E 600 mg / oral / daily + topical Diclofenac sodium 4% gel / twice a day, for a period of 6 months. Group B=the same therapy of group A but without PTX penile injection. Patients who refused treatment, for various reasons, were included in the control group=Group C (80 patients). Results: In groups A and B after 6 months of treatment a reduction of penile plaque volume of 50.3% and 25.9% respectively was observed, while in group C a mean increase in plaque volume of 131% was observed. Furthermore, in groups A and B, the mean curvature decrease was -11.07° and -4.4° respectively, while in group C a mean increase of curvature =+14.09° was observed. Conclusion: Our results showed that multimodal treatment with PTX associated with antioxidants and topical Diclofenac is significantly effective in treating PD. Treatment outcomes obtained in the treatment-group A are statistically more significant than those achieved in group B. Pentoxifylline is more effective when the treatment program includes both routes of administration: oral + perilesional injection.

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Long-Term Multimodal Therapy (Verapamil Associated with Propolis, Blueberry, Vitamin E and Local Diclofenac) on Patients with Peyronie's Disease (Chronic Inflammation of the Tunica Albuginea). Results of a Controlled Study

Cited by 34 publications

References 32 publications

Blueberry Improves the Therapeutic Effect of Etanercept on Patients with Juvenile Idiopathic Arthritis: Phase III Study

Blueberry Improves the Therapeutic Effect of Etanercept on Patients with Juvenile Idiopathic Arthritis: Phase III Study

Blueberries inhibit cyclooxygenase-1 and cyclooxygenase-2 activity in human epithelial ovarian cancer

Pentoxifylline Associated with Other Antioxidants (Multimodal Therapy) on Patients with Peyronie's Disease. Results of a Controlled Study

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