Long-term nebivolol administration reduces renal fibrosis and prevents endothelial dysfunction in rats with hypertension induced by renal mass reduction

Pires, Maria dos Anjos; Rodríguez-Peña, Ana B.; Arévalo, Miguel; Cenador, Begoña García; Evangelista, Stefano; Esteller, A; Sánchez‐Rodríguez, Ángel; Colaço, Aura; López‐Novoa, José M.

doi:10.1097/hjh.0b013e3282efeecb

Cited by 32 publications

(41 citation statements)

References 58 publications

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“…It leads to an increase in renal NO excretion and a significant increase in renal plasma flow and GFR, 37 reduces endothelin-1, 38 and has an antioxidant effect, 39 all of which are related to the pathogenesis of CN. Based on these characteristics of nebivolol, Toprak et al conducted an experimental study to investigate nebivolol's protective effects, 11 finding that nebivolol decreased medullary congestion, proteinaceous casts, and tubular necrosis caused by CM.…”

Section: Discussionmentioning

confidence: 99%

The usefulness of carvedilol and nebivolol in preventing contrast nephropathy in rats

et al. 2015

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Background: Oxidative stress and vasoconstriction appear to be important components of contrast nephropathy (CN) pathogenesis, and both carvedilol and nebivolol are known to have vasodilatory and antioxidant effects. Aims: This study aimed to investigate whether carvedilol and nebivolol play preventive roles against developing CN and to compare the effects of each. Materials and methods: Wistar albino rats were divided into control (C, n ¼ 6), contrast material (CM, n ¼ 6), carvedilol (CV, n ¼ 7), carvedilol + contrast material (CV + CM, n ¼ 7), nebivolol (N, n ¼ 7), and nebivolol + contrast (N + CM, n ¼ 7) groups. Following 3 days of dehydration, 6 mL/kg diatrizoate was administered to each rat. Carvedilol was given at a dose of 2 mg/kg and nebivolol at a dose of 1 mg/kg by way of oral gavage. After scarification, total antioxidant capacity (TAC), malondialdehyde (MDA), and superoxide dismutase (SOD) were studied in renal tissue. Histopathological findings were graded as mild (+), moderate (++), and severe (+++). Results and discussion: Most of the histopathological findings and MDA levels were significantly higher in the CM group than that in the C, CVCM, and NVCM groups, whereas there was no significant difference between the C, CVCM and NVCM groups. TAC level in the CM group was significantly lower than in all other groups. There was no difference in SOD among groups. Conclusions: Carvedilol and nebivolol both prevent development of nephropathy related to CMs by decreasing oxidative stress. Neither is superior to the other.

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Section: Discussionmentioning

confidence: 99%

The usefulness of carvedilol and nebivolol in preventing contrast nephropathy in rats

et al. 2015

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“…Hence, this model is used to study different aspects of CKD, namely to assess the potential renoprotective effects of new drugs (8,9). Detection of renal damage and fibrosis in this model is very important in chronic studies and finding a noninvasive means of its detection would provide tremendous utility in experimental studies.…”

Section: Discussionmentioning

confidence: 99%

“…RMR was performed in 17 rats. The animals were subjected to right nephrectomy and surgical removal of the left kidney poles (8). A sham operation was performed on 13 additional rats as a nonnephrectomized control (sham-operated; SO).…”

Section: Methodsmentioning

confidence: 99%

Ultrasonographic Evaluation of the Kidney in 5/6 Nephrectomized Rats: Correlation with Biochemical and Histopathological Findings

Nogueira

Faustino-Rocha

Ginja

et al. 2016

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“…[9] It is reported to possess antihypertensive, anti-oxidant activity, and also reduces renal fibrosis and prevents endothelial dysfunction. [10,11] So far, no report has proved that treatment with nebivolol could improve the survival rate after renal warm I/R injury. The present study examined whether treatment with nebivolol improve the survival rate in a renal warm I/R injury using a rat model, as renal I/R injury is due to the over-activation of sympathetic β1 receptor activity that ultimately leads to a functional deficiency of NO.…”

Section: Introductionmentioning

confidence: 99%

Nebivolol Reduces Experimentally Induced Warm Renal Ischemia Reperfusion Injury in Rats

2008

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Ischemia/reperfusion injury, which is commonly seen in the field of renal surgery or transplantation, is a major cause of acute renal failure. The objective of the present study was to examine the role of nebivolol in modulating peroxynitrite species-induced inflammation and apoptosis after renal warm ischemia/ reperfusion injury in rats. The present study was designed to investigate the effects of nebivolol on the renal warm ischemia/ reperfusion injury in rats treated with the nitric oxide synthase inhibitor, N ω -nitro-L-arginine methyl ester. After right nephrectomy, nebivolol was administered for 15 days. On the 16 th day, ischemia was induced in contra lateral kidney for 45 min, followed by reperfusion for 24 hr. Renal function, inflammation, and apoptosis were estimated at the end of 24 hr reperfusion. Nebivolol improved the renal dysfunction and reduced inflammation and apoptosis after renal ischemia/reperfusion injury. In conclusion, nebivolol shows potent anti-apoptotic and anti-inflammatory properties due to its NO-releasing property. These findings may have major implications in the treatment of human ischemic acute renal failure.

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Long-term nebivolol administration reduces renal fibrosis and prevents endothelial dysfunction in rats with hypertension induced by renal mass reduction

Abstract: Nebivolol protects against renal fibrosis, oxidative stress and endothelial dysfunction better than equivalent doses, in terms of arterial pressure reduction, of atenolol in a hypertensive model of renal damage induced by RMR.

Cited by 32 publications

References 58 publications

The usefulness of carvedilol and nebivolol in preventing contrast nephropathy in rats

The usefulness of carvedilol and nebivolol in preventing contrast nephropathy in rats

Ultrasonographic Evaluation of the Kidney in 5/6 Nephrectomized Rats: Correlation with Biochemical and Histopathological Findings

Nebivolol Reduces Experimentally Induced Warm Renal Ischemia Reperfusion Injury in Rats

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