Long-term Observations of Proton-Irradiated Monkey Eyes

Gragoudas, Evangelos S.; Zakov, Nicholas; Albert, Daniel M.; Constable, Ian

doi:10.1001/archopht.1979.01020020502020

Cited by 47 publications

(6 citation statements)

References 16 publications

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“…65 Further, normal retinal architecture as close as 1 mm from the edge of such lesions was observed over 3 years after proton irradiation. 66 Once the concept of the utility of proton beam irradiation for ocular melanoma had been established, further research was performed to improve the accuracy with which this therapy could be delivered. This concept was substantiated by the results we observed after treatment in our earliest patients.…”

Section: Charged-particle Irradiation With Protonsmentioning

confidence: 40%

Proton Beam Irradiation of Uveal Melanomas: The First 30 Years The Weisenfeld Lecture

Gragoudas¹

2006

Invest. Ophthalmol. Vis. Sci.

104

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Section: Charged-particle Irradiation With Protonsmentioning

confidence: 40%

Proton Beam Irradiation of Uveal Melanomas: The First 30 Years The Weisenfeld Lecture

Gragoudas¹

2006

Invest. Ophthalmol. Vis. Sci.

104

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“…A marked effect of fractionation was seen: 125 Gy/5 fx produced the same effect at 24 hours and at 1 year as 30 Gy in a single pulse [19]. Chorioretinal changes persisted within the irradiated area at 42 to 51 months, while normal retinal architecture was preserved immediately outside the discrete retinal scar produced by the proton beam [20].…”

Section: Pre-clinical Studiessupporting

confidence: 39%

Proton therapy for uveal melanomas and other eye lesions

Munzenrider

1999

Strahlenther Onkol

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Charged particle beams are ideal for treating intra-ocular lesions, since they can be made to deposit their dose in the target, while significantly limiting dose received by non-involved ocular and orbital structures. Proton beam treatment of large numbers of uveal melanoma patients consistently achieves local control rates in excess of 95%, and eye retention rates of approximately 90%. Visual preservation is related to initial visual acuity, tumor size and location, and dose received by the macula, disc, and lens. The probability of distant metastasis is increased by larger tumor diameter, more anterior tumor location, and older patient age. Proton therapy is also effective treatment for patients with ocular angiomas, hemangiomas, metastatic tumors, and retinoblastomas, and may be beneficial for patients with exudative ("wet") age-related macular degeneration.

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“…Histologically, there is occlusion of vessels within the choroidocapillaris, pigment dispersion with reduced numbers of melanocytes and corresponding areas devoid of photoreceptor cells. Attenuation of photoreceptors and the nerve fibre layer, invasion of retinal tissue with macrophages, and subretinal fibrosis have also been reported (Gragoudas et al. 1979; Krebs et al.…”

Section: Complications Of Ocular and Periocular Radiotherapymentioning

confidence: 99%

Ophthalmic and adnexal complications of radiotherapy

Durkin

Roos

Higgs

et al. 2006

Acta Ophthalmologica Scandinavica

136

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ABSTRACT.The role of radiotherapy in ophthalmic practice continues to grow. This growth has seen an expansion of indications for radiotherapy, a refinement of the modalities that can be used and a reduction in the ocular and adnexal complications that result from this form of therapy. The compendium of indications for radiotherapy in ophthalmology continues to grow and now includes many conditions such as the treatment of lid and adnexal disease, ocular surface disorders and both benign and malignant disease of the posterior segment and optic pathways. The radiotherapeutic modalities employed to manage these conditions are numerous and include both radioactive plaques (brachytherapy) and external beam radiation techniques. New techniques such as stereotactic radiosurgery are delivering benefits in the management of conditions such as optic nerve sheath meningioma, where the treatment of this blinding and occasionally life-threatening intracranial neoplasm now results in fewer adverse affects. The purpose of this review is to give a brief overview of the indications and treatment modalities, and a more in-depth discussion of the potential side-effects when radiotherapy is used for ocular and periorbital disease.

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Long-term Observations of Proton-Irradiated Monkey Eyes

Cited by 47 publications

References 16 publications

Proton Beam Irradiation of Uveal Melanomas: The First 30 Years The Weisenfeld Lecture

Proton Beam Irradiation of Uveal Melanomas: The First 30 Years The Weisenfeld Lecture

Proton therapy for uveal melanomas and other eye lesions

Ophthalmic and adnexal complications of radiotherapy

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