Long-term oncological outcomes after robotic partial nephrectomy for renal cell carcinoma: a prospective multicentre study

Beauval, Jean-Baptiste; Peyronnet, B.; Benoit, T.; Seisen, Thomas; Roumiguié, M.; Pradère, Benjamin; Khene, Z.; Manach, Q.; Verhoest, G.; Thoulouzan, M.; Parra, J.; Doumerc, N.; Mathiéu, Romain; Vaessen, Christophe; Soulié, M.; Rouprêt, Morgan; Bensalah, Karim

doi:10.1007/s00345-018-2208-8

Cited by 27 publications

(19 citation statements)

References 25 publications

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“…However, oncologic survival data is not reported. Several contemporary studies have reported excellent five-year oncologic outcomes for RAPN; however, these studies document outcomes for smaller patient cohorts compared to the present study and do not report oncologic outcomes with respect to surgical margin status (21)(22)(23)(24). In the current study we present longterm oncologic outcomes for a larger cohort of patients with renal cortical neoplasms exclusively managed by RAPN.…”

Section: Discussioncontrasting

confidence: 55%

Long-term oncologic outcomes of positive surgical margins following robot-assisted partial nephrectomy

Rothberg¹,

Peak²,

Reynolds³

et al. 2020

Transl Androl Urol

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Background: Previous reports on positive surgical margin (PSM) after robot-assisted partial nephrectomy (RAPN) have reached inconsistent conclusions as to the impact of a PSM on oncologic outcomes. We sought to determine the effect of PSM on long-term cancer recurrence and survival outcomes. Methods: We queried our renal oncology database for patients having undergone RAPN and compared recurrence-free survival (RFS) and overall survival (OS) between patients with PSM and negative surgical margin (NSM). Kaplan-Meier analysis was also performed for RFS and OS for PSM versus NSM. Results: Of the 432 patients who underwent RAPN we identified 29 (6.7%) patients with PSM and 403 (93.3%) patients with NSM. Median follow-up for the overall cohort was 45.1 months. Three of the 29 patients with PSM and fourteen of the 403 patients with NSM had disease recurrence (P=0.09).RFS at 24, 48, and 72 months was 95.8%, 90%, and 85.5% for patients with NSM and 96.6%, 86.6%, and 80.4% for patients with PSM, respectively (log-rank P value =0.382). OS at 24, 48, and 72 months was 98%, 93.1%, and 89.7% for patients with NSM and 96.3%, 91.2%, and 85.2% for patients with PSM, respectively (log-rank P value =0.584).Conclusions: While PSM are relatively uncommon, their presence still serves as a potential risk factor for worse oncologic outcomes. In instances of PSM, immediate secondary intervention is most likely unnecessary and more attentive long-term clinical follow-up, especially in patients with high-risk features, may be more advisable.

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Section: Discussioncontrasting

confidence: 55%

Long-term oncologic outcomes of positive surgical margins following robot-assisted partial nephrectomy

Rothberg¹,

Peak²,

Reynolds³

et al. 2020

Transl Androl Urol

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“…Although we began our robotic surgery experience with cases classified as "very difficult", such as partial nephrectomy and radical prostatectomy, our complication rate in the first 18 months was consistent with the literature (17,18). As the surgeons gained experience, they began to perform the cases classified as "extremely difficult" and their complication rates were decreased.…”

Section: Discussionsupporting

confidence: 77%

Complications of Robotic Surgery in Urology: Our Experience of 342 Procedures Including the Learning Curve

İslamoğlu¹,

Anıl²,

Karamık³

et al. 2018

jus

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“…The efficacy and safety of RAPN have been extensively investigated. This procedure reportedly achieves promising intermediate and long‐term outcomes 3,4 . However, few studies have examined the QOL after RAPN.…”

Section: Introductionmentioning

confidence: 99%

Robot‐assisted partial nephrectomy with minimum follow‐up of 5 years: A multi‐center prospective study in Japan

et al. 2022

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Objectives: Robot-assisted partial nephrectomy is widely performed for small renal masses, achieving excellent perioperative and intermediate oncological outcomes. However, long-term oncological, functional, and quality of life outcomes after robotassisted partial nephrectomy remain unclear. In this study, we aimed to evaluate quality of life at 1 year and oncological and functional outcomes of robot-assisted partial nephrectomy after a minimum follow-up of 5 years. Methods: Personal, perioperative, postoperative, functional, oncological, and quality of life data were evaluated. The EQ-5D-5L tool, which incorporates health profiles and a EuroQol Visual Analog Scale, was used to assess quality of life preoperatively and 365 days postoperatively. Regarding oncological and functional outcomes, overall survival, recurrence-free survival, and changes in estimated glomerular filtration rate were calculated. Results: There were few changes in levels between the two time points for all EQ-5D dimensions. The mean change in EQ-5D-5L was 0.020 (95% confidence interval 0.006-0.033, P = 0.006), and in EuroQol Visual Analog Scale score 4.60 (95% confidence interval 2.17-7.02, P = 0.0003). Overall and recurrence-free survival 5 years after robot-assisted partial nephrectomy were 97.9% and 92.8%, respectively. After an early postoperative decrease, the estimated glomerular filtration rate remained stable over time. Conclusions: Robot-assisted partial nephrectomy in patients with a T1 renal tumor is safe, feasible, and effective from the perspective of quality of life and survival, even after 5 years. When making treatment decisions, perioperative and quality of life outcomes should be considered together with long-term oncological outcomes.

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Long-term oncological outcomes after robotic partial nephrectomy for renal cell carcinoma: a prospective multicentre study

Abstract: In this multicenter series, long-term OS, DFS and CSS after RPN appeared comparable to large series of open partial nephrectomy, with no port-site metastasis and one case of peritoneal carcinomatosis.

Cited by 27 publications

References 25 publications

Long-term oncologic outcomes of positive surgical margins following robot-assisted partial nephrectomy

Long-term oncologic outcomes of positive surgical margins following robot-assisted partial nephrectomy

Complications of Robotic Surgery in Urology: Our Experience of 342 Procedures Including the Learning Curve

Robot‐assisted partial nephrectomy with minimum follow‐up of 5 years: A multi‐center prospective study in Japan

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