Long-Term Oral Appliance Therapy Improves Daytime Function and Mood in Upper Airway Resistance Syndrome Patients

Abstract

Efficacy of Oral Appliance for Upper Airway Resistance Syndrome: Randomized, Parallel, Placebo-Controlled Study, NCT02636621.

To compare different non-surgical treatment modalities on treatment of obstructive sleep apnea: A systematic review and meta-analysis

“…Summary of characteristic of the included studies is presented in Table 1 . Out of 21 studies,[ 17 19 22 23 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 ] 11 studies compared MAD and CPAP, while 10 studies compared MAD and sham.…”

“…In sequence generation, 70% of studies showed low risk of bias and 30% showed unclear risk of bias. Methods of sequence generation were computer-generated random number,[ 23 38 42 48 52 53 54 56 59 62 65 68 69 73 74 ] block randomization,[ 16 22 43 44 47 60 71 ] and block of four. [ 40 67 ] Many studies did not mention method of sequence generation.…”

“…Methods of allocation concealment used were sealed opaque envelope,[ 16 23 47 52 65 66 68 ] telephonic allocation,[ 69 ] flipping card,[ 50 ] sequence of arrival,[ 48 ] software,[ 45 ] and method not mentioned. [ 17 19 20 22 38 39 40 41 42 43 44 46 49 51 53 54 55 58 59 60 61 62 63 64 67 70 71 72 73 ]…”

“…Few studies mentioned trial registry number and published studies followed trial document. [ 17 23 38 48 52 57 60 65 68 71 73 ]…”

“…Forest plot comparing AHI between MAD and sham included nine studies having 237 patients in the MAD group and 233 patients in the sham group [ Figure 2 ]. Out of nine studies, 5 studies[ 59 62 65 66 70 ] favored the MAD, but 4 studies[ 63 64 69 71 ] gave unclear result. Compared with sham, MAD significantly decreased AHI (weighted mean difference: 8.39, 95% confidence level [CI]: 10.90–5.88).…”