Long term outcome of benign childhood epilepsy with centrotemporal spikes: Dutch Study of Epilepsy in Childhood

Callenbach, Petra M. C.; Bouma, P.; Geerts, Ada T.; Arts, W. F. M.; Stroink, Hans; Peeters, Els; Donselaar, Cees A. van; Peters, A. C. B.; Brouwer, Oebele F.

doi:10.1016/j.seizure.2010.07.007

Cited by 75 publications

(65 citation statements)

References 29 publications

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“…1,2 The spontaneous remission occurs in almost 90% of patients with BECT before the age of 16 years. 1,3 The distinctive clinical manifestations include shortlasting focal motor or sensory seizures that occur during sleep, 1,3 specific biphasic sharp wave discharges arising from the centrotemporal regions (rolandic spikes).…”

Section: Introductionmentioning

confidence: 99%

“…1,3 The distinctive clinical manifestations include shortlasting focal motor or sensory seizures that occur during sleep, 1,3 specific biphasic sharp wave discharges arising from the centrotemporal regions (rolandic spikes). 2 Ciumas and colleagues illustrated diffusion tensor imaging (DTI) evidence of white matter (WM) abnormalities in patients with BECT, suggesting that the abnormal developmental trajectory of the brain is influenced by epileptic activity. 4 BECT is therefore considered a development disease.…”

Section: Introductionmentioning

confidence: 99%

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Altered Structural and Functional Feature of Striato-Cortical Circuit in Benign Epilepsy with Centrotemporal Spikes

Chen

Zhang

Cao

et al. 2015

Int. J. Neur. Syst.

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Benign epilepsy with centrotemporal spikes (BECT) is the most common form of childhood idiopathic focal epilepsy syndrome. We investigated quantitative evidence regarding brain morphology and functional connectivity features to provide insight into the neuroanatomical foundation of this disorder, using high resolution T1-weighted magnetic resonance imaging (MRI) and resting state functional MRI in 21 patients with BECT and in 20 healthy children. The functional connectivity analysis, seeded at the regions with altered gray-matter (GM) volume in voxel-based morphometry (VBM) analysis, was further performed. Then, the observed structural and functional alteration were investigated for their association with the clinical and behavior manifestations. The increased GM volume in the striatum and fronto-temporo-parietal cortex (striato-cortical circuit) was observed in BECT. The decreased connections were found among the motor network and frontostriatal loop, and between the default mode network (DMN) and language regions. Additionally, the GM of striatum was negatively correlated with age at epilepsy onset. The current observations may contribute to the understanding of the altered structural and functional feature of striato-cortical circuit in patients with BECT. The findings also implied alterations of the motor network and DMN, which were associated with the epileptic activity in patients with BECT. This further suggested that the onset of BECT might have enduring structural and functional effects on brain maturation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Altered Structural and Functional Feature of Striato-Cortical Circuit in Benign Epilepsy with Centrotemporal Spikes

Chen

Zhang

Cao

et al. 2015

Int. J. Neur. Syst.

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“…In benign childhood epilepsy with centrotemporal spikes (BCECTS), the marked agespecific onset and remission of electroclinical features, comorbid behavioral and cognitive problems, and genetic predisposition strongly suggest altered brain maturation [1][2][3][4][5]. To further understand developmental disorders of this nature, magnetic resonance imaging (MRI) analysis techniques have been used to identify the microstructural alterations of the brain in children with idiopathic focal epilepsy including BCECTS [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Structural abnormalities in benign childhood epilepsy with centrotemporal spikes (BCECTS)

Kim

Yum

Shim

et al. 2015

Seizure

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“…It has been reported that antiepileptic drugs cause transient cognitive dysfunction in BECTS children, and BECTS children have normal cognitive function one year after antiepileptic drugs are discontinued due to control of epileptic symptoms [11]. Furthermore, several studies have shown that BECTS children with higher intelligence levels are more likely associated with shorter duration of seizure, and greater reading and writing capabilities, and have parents with higher education levels [3,10,12,13,14,15]. …”

Section: Introductionmentioning

confidence: 99%

Language Dysfunction Is Associated with Age of Onset of Benign Epilepsy with Centrotemporal Spikes in Children

Ma¹,

Chen²,

Wang³

et al. 2015

Eur Neurol

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Aims: To assess the language function of children with benign epilepsy with centrotemporal spikes (BECTS), and investigate associated risk factors. Methods: The language function of 63 children with BECTS and 30 healthy controls was assessed using the language subtest of the Chinese version of the Wechsler Intelligence Scale for Children (C-WISC). Multiple linear regression analysis was applied to assess the risk factors of language dysfunction in children with BECTS. Results: The total score of language test of C-WISC, and the individual scores, were significantly lower in children with BECTS compared with the scores attained by the healthy controls, and were also significantly lower in children with BECTS with onset earlier than 6 years of age compared with those whose disease onset occurred later. There were no significant correlations between language function and treatment, frequency of seizures, lateralization of centrotemporal spikes, or duration of seizures, but there was a positive correlation between language dysfunction and the age at disease onset. Conclusion: Children with BECTS have language difficulties, especially those with earlier disease onset. Early age at seizure onset is a risk factor for language dysfunction in children with BECTS.

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Long term outcome of benign childhood epilepsy with centrotemporal spikes: Dutch Study of Epilepsy in Childhood

Cited by 75 publications

References 29 publications

Altered Structural and Functional Feature of Striato-Cortical Circuit in Benign Epilepsy with Centrotemporal Spikes

Altered Structural and Functional Feature of Striato-Cortical Circuit in Benign Epilepsy with Centrotemporal Spikes

Structural abnormalities in benign childhood epilepsy with centrotemporal spikes (BCECTS)

Language Dysfunction Is Associated with Age of Onset of Benign Epilepsy with Centrotemporal Spikes in Children

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