Long-term outcome of children with congenital toxoplasmosis

Berrébi, Alain; Assouline, Corinne; Bessières, Marie-Hélène; Lathiere, M.; Cassaing, Sophie; Minville, Vincent; Ayoubi, Jean-Marc

doi:10.1016/j.ajog.2010.06.002

Cited by 99 publications

(81 citation statements)

References 34 publications

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“…39,40 Although none of the neonates in this study showed any detectable symptoms (100%, 27/27), with the relatively small sample size of T. gondii positive neonates, this is not significantly different from 80-90% found in the previously reported studies. 39,40 One of the limitations of this study is that detection is based on PCR and this means that it is possible that it does not represent living parasites, but parasite DNA molecules. While this has to be acknowledged, PCR is used widely as a diagnostic tool for Toxoplasma 1 and a wide range of other protozoan parasitic diseases.…”

Section: Discussioncontrasting

confidence: 71%

High frequency detection ofToxoplasma gondiiDNA in human neonatal tissue from Libya

Haq

Abushahama

Gerwash

et al. 2016

Trans R Soc Trop Med Hyg

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Background: Toxoplasma gondii is a parasite that causes significant disease in humans. Toxoplasmosis is normally asymptomatic, unless associated with congenital transmission, or in immunocompromised people. Congenital transmission generally occurs at low frequencies. In this study, we use PCR to investigate possible congenital transmission of T. gondii during pregnancy in a cohort of mothers from Libya.Methods: Two hundred and seventy two pregnant women (producing 276 neonates) were recruited to obtain umbilical cord tissue from their neonates at birth; DNA was extracted from that tissue and tested for T. gondii DNA using two specific PCR protocols based on the sag 1 and sag 3 genes.Results: Toxoplasma gondii DNA was detected in the umbilical cord DNA from 27 of the 276 neonates giving a prevalence of 9.9% (95% CI 6.8-13.9%). Compared with more commonly reported rates of congenital transmission of 0.1% of live births, this is high. There was no association of infection with unsuccessful pregnancy.Conclusions: This study shows a high frequency presence of T. gondii DNA associated with neonatal tissue at birth in this cohort of 276 neonates from Libya. Although PCR cannot detect living parasites, there is the possibility that this indicates a higher than usual frequency of congenital transmission.

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Section: Discussioncontrasting

confidence: 71%

High frequency detection ofToxoplasma gondiiDNA in human neonatal tissue from Libya

Haq

Abushahama

Gerwash

et al. 2016

Trans R Soc Trop Med Hyg

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show abstract

“…Head ultrasonography has been used mainly in cohorts in Europe, 97,129,184 where the rate of symptomatic CT cases is very low compared with the United States. (Limited comparative data have shown that ultrasonography of the head had lower sensitivity than computed tomography of the head for intracranial calcifi cations 96 ; published empirical data on the comparative performance of MRI, ultrasonography, or computed tomography of the head are lacking, but brain MRI could also be considered for the initial evaluation because it obviates the risk of radation associated with head CT.) • Abdominal ultrasonography at birth for intrahepatic calcifi cations and/or hepatosplenomegaly 185 Montoya et al, 186 and Montoya et al 152 an eventual diagnosis of eye disease had lesions detected at their fi rst examination.…”

Section: • If Maternal Serologic Test Results Was Suggestive Of An Acumentioning

confidence: 99%

“…97,133 In a large French cohort study by Berrebi et al 129 137 This proportion increased to almost 50% when the follow-up was extended to 18 years of age. The eye lesions were first seen at a median age of 3 years (range: 0.0-20.7 years).…”

Section: Long-term Risk Of Eye Diseasementioning

confidence: 95%

Diagnosis, Treatment, and Prevention of Congenital Toxoplasmosis in the United States

Maldonado¹,

Read²,

et al. 2017

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“…Conversely maternal infection in the third trimester often results in asymptomatic newborns. However, if not treated appropriately, these newborns might develop retinochoroiditis and neurological deficits like delayed motor skillness, feeding difficulty, hearing impairment, vision problems, seizures and mild to severe mental retardation during the first two decades of life in childhood or early adulthood 11 . Therefore, early and rapid diagnosis of toxoplasmosis is essential in pregnancy to prevent these fatal bad obstetric outcomes.…”

Section: Discussionmentioning

confidence: 99%

Toxoplasma gondii specific IgG avidity assay: Role and implication in the confirmatory diagnosis of acute toxoplasmosis in seropositive pregnant women

Naheen

Tarafder

Sattar

et al. 2016

Bangabandhu Sheikh Mujib Medical University Journal

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This study was undertaken to apply Toxoplasma gondii specific IgG avidity test in seropositive pregnant women to differentiate acute and past infection. T. gondii specific IgG avidity test was conducted in 39 seropositive pregnant women and their pregnancy outcomes were observed later on. Out of 39 T. gondii seropositive pregnant women 33 (84%) were only IgG positive and 6 (15.4%) were both IgG-IgM positive. All the IgG positive cases (100%) and 2(33.3%) IgG-IgM positive cases had high avidity antibodies and they gave birth to healthy babies. Rest of the 4 (66.7%) IgG-IgM positive women had low avidity and 50% of them had abortion and 50% gave birth to unhealthy babies. This reveals that the seropositive mothers having high IgG avidity had past infection and no risk of congenital transmission. Seropositive mothers having low IgG avidity had acute infection and so congenital transmission occurred. Presence of T. gondii specific IgG and IgM antibody does not indicate acute infection always. IgG-IgM positive pregnant women should be further evaluated by IgG avidity assay to confirm acute infection.

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Long-term outcome of children with congenital toxoplasmosis

Cited by 99 publications

References 34 publications

High frequency detection ofToxoplasma gondiiDNA in human neonatal tissue from Libya

High frequency detection ofToxoplasma gondiiDNA in human neonatal tissue from Libya

Diagnosis, Treatment, and Prevention of Congenital Toxoplasmosis in the United States

Toxoplasma gondii specific IgG avidity assay: Role and implication in the confirmatory diagnosis of acute toxoplasmosis in seropositive pregnant women

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