Long‐term outcome of the treatment of high‐risk tenosynovial giant cell tumor/pigmented villonodular synovitis with radiotherapy and surgery

Griffin, Anthony M.; Ferguson, Peter C.; Catton, Charles; Chung, Peter; White, Lawrence M.; Wunder, Jay S.; Bell, Robert S.; O’Sullivan, Brian

doi:10.1002/cncr.26529

Cited by 79 publications

(82 citation statements)

References 40 publications

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“…It was previously called pigmented villonodular synovitis (PVNS). It occurs in two forms -localized, which is characterized by a solitary, pedunculated lesion surrounded by normal synovium, and diffuse, which involves a majority of the synovium [21]. In the knee, the most commonly affected joint, a localized form usually occurs in the anteromedial compartment at the meniscocapsular junction [22,23].…”

Section: Tenosynovial Giant Cell Tumour/pigmented Villonodular Synovitismentioning

confidence: 99%

T2 black lesions on routine knee MRI: differential considerations

et al. 2015

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The majority of abnormal findings or lesions on T2-weighted fast spin-echo (FSE) magnetic resonance imaging (MRI) are hyperintense due to increased perfusion or fluid content, such as infections, tumours or synovitis. Hypointense lesions on T2-weighted images (both fat-suppressed and non-fat-suppressed) are less common and can sometimes be overlooked. Such lesions have limited differential diagnostic possibilities, and include vacuum phenomenon, loose body, tenosynovial giant cell tumour, rheumatoid arthritis, haemochromatosis, gout, amyloid, chondrocalcinosis, hydroxyapetite deposition disease, lipoma arborescens, arthrofibrosis and iatrogenic lesions. These lesions often show characteristic appearances and predilections in the knee. In this article, the authors describe the MRI features of hypointense T2 lesions on routine knee MRI and outline a systematic diagnostic approach towards their evaluation. Key Points • Hypointense lesions on T2 images (T2 Dark Lesions) encompass limited diagnostic possibilities. • T2 Dark lesions often show characteristic appearances and predilections in the knee. • A systematic diagnostic approach will help radiologists make the correct diagnosis.

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Section: Tenosynovial Giant Cell Tumour/pigmented Villonodular Synovitismentioning

confidence: 99%

T2 black lesions on routine knee MRI: differential considerations

et al. 2015

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“…For this reason, the correct diagnosis of the disease is a considerable challenge (2,9,13). Additional auxiliary examinations should be performed, and detailed information from patients should be recorded, which is vital for the confirmation of a therapeutic schedule (4,5,13,15).…”

Section: Discussionmentioning

confidence: 99%

“…The pathogenesis of D-GCTS has not been clarified, and certain studies have concluded that the cause of disease is associated with bleeding subsequent to trauma and lipid metabolism disorders (5,13,15).…”

Section: Discussionmentioning

confidence: 99%

“…Image findings in previous studies reveal these soft tissue masses occur beside small joints (9,11). If the results of image analysis demonstrate that the lesions have invaded the joints, and if there is a concurrent weak signal of T1W and T2W on a magnetic resonance imaging (MRI) scan, D-GCTS should be considered as a probable diagnosis (12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

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Diffuse-type giant cell tumor of the tendon sheath in the temporal region incidentally diagnosed due to a temporal tumor: A report of two cases and review of the literature

Qin

Jin

et al. 2015

Oncology Letters

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Abstract. Diffuse-type tenosynovial giant cell tumor (D-GCTS) is a rare benign lesion that not only frequently occurs in the fingers, but also along the tendon sheaths of the foot and ankle. The present study reports the cases of two middle-aged patients that were diagnosed with D-GCTS. The presentation of the D-GCTS lesions was extremely rare, as the tumors were located in the temporal fossa and threatened the skull base and external auditory canal. There were similarities and differences between the two patients in their clinical symptoms, disease progressions and invading sites. The patients' disease course occurred unnoticed with the absence of pain, was protracted and became infiltrative. However, the female patient was admitted to the hospital due to the occurrence of pain in the left temporal region, and the male patient presented at the doctor due to a painless left temporal mass and external auditory canal bleeding. Therefore, the operation area of the two patients was not the same. This type of illness should be considered in the differential diagnosis for masses occurring in the temporal region. Total tumor removal is the best treatment for D-GCTS, and the careful monitoring of recurrence can achieve a good clinical outcome subsequent to the surgical resection. IntroductionGiant cell tumor of the tendon sheath (GCTS) was initially described by Chassaignac in 1852 (1), and the lesion was defined as a malignant tumor at that time (2). Subsequently, Heurteux produced a detailed description of GCTS (3). It was found that the disease occurs more frequently in middle-aged women compared with men (4). According to the position (large or facet joint; intra-or extra-articular), characteristics (benign or malignant) and growth pattern (diffuse or localized) of the tumor, GCTS may be classified as one of four types: Localized-type tenosynovial giant cell tumor (L-GCTS); diffuse-type tenosynovial giant cell tumor (D-GCTS); pigmented villonodular synovitis (PVNS) (5,6); and malignant tenosynovial giant cell tumor (M-GCTS) (7,8).D-GCTS demonstrates invasive growth in the local region, which is considerably different from L-GCTS. D-GCTS usually develops in the synovium, and often invades the surrounding knee and soft tissue (2,9). Since it arises mainly from the soft tissue outside the joints, Weiss et al (10) regarded D-GCTS as a type of PVNS that appears in the soft tissue outside the joints, and also presents with intra-articular lesions (2,5). L-GCTS mainly occurs in the small joints, including the hand, foot and ankle. Image findings in previous studies reveal these soft tissue masses occur beside small joints (9,11). If the results of image analysis demonstrate that the lesions have invaded the joints, and if there is a concurrent weak signal of T1W and T2W on a magnetic resonance imaging (MRI) scan, D-GCTS should be considered as a probable diagnosis (12-15).GCTS usually occurs in individuals between the ages of 30 and 50 years (5). As a painless and slow-growing disease, it has been termed an innocent tumor ...

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“…Functional results after surgical treatment for PVNS have been reported (Table 5) [3,[18][19][20][21][22][23][24][25][26][27][28][29][30][31][32], but comparison is difficult, as functional results were not specified for diffuse and localized disease, type of surgery, primary or recurrent disease and different localizations. In this study, there was no difference in functional outcome and QOL between patients who underwent primary arthroscopic or open synovectomy.…”

Section: Discussionmentioning

confidence: 99%

Pigmented villonodular synovitis: a crowdsourcing study of two hundred and seventy two patients

Heijden

Piner

Sande

2016

International Orthopaedics (SICOT)

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Purpose We aimed to ascertain the feasibility of crowdsourcing via Facebook for medical research purposes; by investigating surgical, oncological and functional outcome and quality-of-life (QOL) in patients with pigmented villonodular synovitis (PVNS) enrolled in a Facebook community (1112 members). Methods Patients completed online open surveys on demographics, surgery and clinical outcomes (group 1); and patient-reported outcome measures (PROMs) including knee-injury osteoarthritis outcome score (KOOS), hipdisability osteoarthritis outcome score (HOOS), Toronto extremity salvage score (TESS) and SF-36 (group 2). Mean follow-up was 70 months (12-374). Consistency checks were performed with Cohen's kappa statistic for intra-rater agreement. Results The first survey was completed by 272 patients (group 1) and 72 patients completed the second (group 2). In group 1, recurrence-rate was 58 % (69/118) after Conclusion Local recurrence-risk was higher for diffusetype disease and arthroscopic synovectomy. Functional outcome and QOL were comparable for both types of surgery. Gathering data via crowdsourcing seems a promising and innovative way of evaluating rare diseases including PVNS.

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Long‐term outcome of the treatment of high‐risk tenosynovial giant cell tumor/pigmented villonodular synovitis with radiotherapy and surgery

Cited by 79 publications

References 40 publications

T2 black lesions on routine knee MRI: differential considerations

T2 black lesions on routine knee MRI: differential considerations

Diffuse-type giant cell tumor of the tendon sheath in the temporal region incidentally diagnosed due to a temporal tumor: A report of two cases and review of the literature

Pigmented villonodular synovitis: a crowdsourcing study of two hundred and seventy two patients

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