Long-Term Outcomes after Surgery for Appendiceal Mucinous Tumours

Dulskas, Audrius; Poškus, Tomas; Poškus, Eligijus; Strupas, Kęstutis

doi:10.1159/000485092

Cited by 9 publications

(7 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is no consensus on the optimal treatment of appendiceal mucocele regarding the type and approach of surgery. Appendicectomy and right hemicolectomy have been proposed for cases of an unruptured appendix, while Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) are proposed in ruptured cases with PMP [ 24 ]. A laparoscopic approach is considered to increase the risk of intraoperative rupture and mucus spread [ 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…Appendicectomy and right hemicolectomy have been proposed for cases of an unruptured appendix, while Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) are proposed in ruptured cases with PMP [ 24 ]. A laparoscopic approach is considered to increase the risk of intraoperative rupture and mucus spread [ 24 , 25 ]. Overall, the 5-year recurrence rate of LAMN has been estimated at 54% following CRS/HIPEC, compared with other epithelial pathologies and given that low-intensity surveillance is recommended [ 23 , 24 , 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Low-Grade Appendiceal Mucinous Neoplasm (LAMN) Primarily Diagnosed as an Ovarian Mucinous Tumor

Perivoliotis

Christodoulidis

Samara

et al. 2021

Case Reports in Surgery

View full text Add to dashboard Cite

Background. Low-grade appendiceal mucinous neoplasms (LAMN) are detected in 0.7 to 1.7% of all appendicectomies. The diagnosis can be challenging, particularly in female patients where the differential diagnosis of primary appendiceal and ovarian mucinous neoplasms is unclear. Case Presentation. A 71-year-old female was referred to our tertiary hospital with the working diagnosis of a right ovarian cystic tumor. The lesion was identified through a transvaginal ultrasound performed for vague lower abdominal pain symptoms. CT scan confirmed these findings. Intraoperatively, an appendiceal mucocele was identified and a right hemicolectomy was performed. The histopathology examination revealed a LAMN. Six months later, the patient remains disease-free. A close biannual oncological follow-up has been suggested. Conclusion. This case underlines the difficulty in determining the origin of mucinous neoplasms of the right pelvic area. Mucocele of the appendix should be considered in the differential diagnosis of a mass in the right iliac fossa.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Low-Grade Appendiceal Mucinous Neoplasm (LAMN) Primarily Diagnosed as an Ovarian Mucinous Tumor

Perivoliotis

Christodoulidis

Samara

et al. 2021

Case Reports in Surgery

View full text Add to dashboard Cite

show abstract

“…In general, ANMA patients suffer significantly poor prognosis than their AMA counterparts. Multiple studies have reported on advances in AMA treatment (24)(25)(26). Currently, CRS and hyperthermic intraperitoneal chemotherapy (HIPEC) have been shown to offer best treatment for AMA (27)(28)(29).…”

Section: Discussionmentioning

confidence: 99%

Post-operative chemotherapy improves the survival of patients with well differentiated widespread metastatic appendiceal non-mucinous adenocarcinomas

Fan

et al. 2021

Ann Palliat Med

View full text Add to dashboard Cite

Background: Appendiceal adenocarcinoma is a very rare type of tumor, often asymptomatic in the early stages of development. Surgical resection is the most preferred intervention against appendiceal nonmucinous adenocarcinoma, but the efficacy of post-operative adjuvant chemotherapy is still unclear because the cancer is rare. Accordingly, we sought to characterize appendiceal non-mucinous adenocarcinoma profile that confers a better survival advantage for post-operative chemotherapy.Methods: We analyzed patients with appendiceal non-mucinous adenocarcinoma in the Surveillance, Epidemiology and End Results database, histologically diagnosed for the cancer between 2004 and 2015.Nearly half of the patients first underwent surgery and thereafter received post-operative chemotherapy.Logistic regression, Kaplan-Meier, univariate and multivariate Cox analysis were performed to evaluate the odds ratio for the propensity of patients underweening chemotherapy, whereas hazard ratios were used to evaluate the overall as well as cancer-specific survival.Results: Of the 724 patients with appendiceal non-mucinous adenocarcinoma who underwent surgery, 301 (41.6%) received post-operative chemotherapy. Notably, patients with metastatic appendiceal nonmucinous adenocarcinoma were more likely to receive chemotherapy (OR =7.42, 95% CI: 5.34-10.39, P<0.001), similar to those with poor pathologically differentiated cancer types (OR =2.10, 95% CI: 1.49-3.00, P<0.001). However, univariate and multivariable Cox regression analyses found no significant overall survival and cancer-specific survival advantage for patients put on postoperative post-operative chemotherapy. In the disease stage and pathological differentiation groups, only patients with widespread metastatic (Stage IV) but well differentiated tumors displayed better 3-year (11.9% in overall survival, 11.5% in cancer-specific survival) and 5-year survival rate (7.8% in overall survival, 6.8% in cancer-specific survival) to post-operative chemotherapy.Conclusions: Staging and grading of appendiceal non-mucinous adenocarcinoma is invaluable in guiding the rationale of post-operative chemotherapy. Findings of this research support the view that only patients with both of widespread metastatic but well differentiated appendiceal non-mucinous adenocarcinoma should be considered for post-operative chemotherapy. Nonetheless, further prospective multidisciplinary clinical trials are necessary to further discern the use chemotherapy after surgery in appendiceal non-mucinous adenocarcinoma patients.

show abstract

“…Likewise, high-grade tumors benefit from debulking surgery and HIPEC, with or without preoperative chemotherapy. 5,12…”

Section: Discussionmentioning

confidence: 99%

Low Grade Appendiceal Mucinous Neoplasm: A Report of Three Cases

Sharma

Karna

Jha

2020

Journal of Institute of Medicine

View full text Add to dashboard Cite

Low-grade appendiceal mucinous neoplasm (LAMN) is an uncommon malignancy with varied clinical features. The most alarming complication of this neoplasm is seeding of mucin into the adjacent peritoneum leading to pseudomyxoma peritonei (PMP). We report three cases of LAMN. Two cases were seen post appendicectomy in 23-year old and 36-year old females. The third case was seen in 53-year-old male post Whipple procedure and hemicolectomy. LAMNs are often diagnosed incidentally, as clinical presentation is barely specific and resembles acute appendicitis. Hence it is imperative to examine all appendicectomy specimens not to miss cases of appendiceal mucinous neoplasm which can have implications on the further management of the patient.

show abstract

Long-Term Outcomes after Surgery for Appendiceal Mucinous Tumours

Cited by 9 publications

References 25 publications

Low-Grade Appendiceal Mucinous Neoplasm (LAMN) Primarily Diagnosed as an Ovarian Mucinous Tumor

Low-Grade Appendiceal Mucinous Neoplasm (LAMN) Primarily Diagnosed as an Ovarian Mucinous Tumor

Post-operative chemotherapy improves the survival of patients with well differentiated widespread metastatic appendiceal non-mucinous adenocarcinomas

Low Grade Appendiceal Mucinous Neoplasm: A Report of Three Cases

Contact Info

Product

Resources

About