Long-Term Outcomes for Laparoscopic Versus Open Resection of Nonmetastatic Colorectal Cancer

Mirza, Muhammad Shahjehan; Longman, Robert; Farrokhyar, Forough; Sheffield, J. P.; Kennedy, Robin H.

doi:10.1089/lap.2007.0169

Cited by 18 publications

(11 citation statements)

References 25 publications

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“…[3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] The characteristics of each randomized controlled trial are presented in Table 1 The intraoperative blood loss and the number of transfused patients in the laparoscopic group were significantly lower than in the open group. There was no significant difference in the number of harvested lymph nodes.…”

Section: Resultsmentioning

confidence: 99%

“…We treated studies that were part of a series as a single study. [7][8][9]11,19,20 Appropriate data from such study series were used for this meta-analysis. This meta-analysis was prepared in accordance with the Quality of Reporting of Meta-analyses statement 21 (Fig.…”

Section: Literature Searchmentioning

confidence: 99%

“…The use of laparoscopic surgery for rectal cancer has recently become more widespread, and several articles have described long-term outcomes associated with the procedure. [4][5][6][7][8][9] However, the curability of rectal cancer using laparoscopic surgery is controversial because the longterm oncologic outcomes of laparoscopic surgery, such as overall mortality, cancer-related mortality, and recurrence rate, remain uncertain. Laparoscopic surgery for rectal cancer is a technically demanding procedure because the surgical space of the rectum is a narrow pelvic cavity surrounded by solid bones, which prevents the manipulation of laparoscopic instruments.…”

Section: Introductionmentioning

confidence: 99%

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A Meta-analysis of the Short- and Long-Term Results of Randomized Controlled Trials That Compared Laparoscopy-Assisted and Conventional Open Surgery for Rectal Cancer

Oda¹,

Tamamori²,

Azuma³

et al. 2011

Journal of Gastrointestinal Surgery

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Section: Resultsmentioning

confidence: 99%

Section: Literature Searchmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Meta-analysis of the Short- and Long-Term Results of Randomized Controlled Trials That Compared Laparoscopy-Assisted and Conventional Open Surgery for Rectal Cancer

Oda¹,

Tamamori²,

Azuma³

et al. 2011

Journal of Gastrointestinal Surgery

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“…Among these, lymph nodes involvement is the most important prognostic factor in colorectal cancer. Laparoscopic surgery for colorectal resection was first reported in 1991 (1)(2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Oncologic Short Term Results of Laparoscopic Versus Open Surgery of Rectal Cancer

Maddah

Abdollahi

et al. 2015

Ann Colorectal Res

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Background: Today, with improvements in laparoscopy technique, surgery of rectal cancer is performed by laparoscopy. Objectives: This study was performed to evaluate oncologic results of open versus laparoscopic surgery of rectal cancer in terms of resection margins, removal of lymph nodes and recurrence rate. Patients and Methods: This descriptive-analytic study was performed on 88 patients with middle and lower rectal cancer in the two equivalent groups of laparoscopic and open surgery in Mashhad Ghaem and Omid hospitals during 2011 -2013. Information including age, sex, number of removed and involved lymph nodes, proximal, distal, and radial margins, tumor stage and location, recurrence and disease-free survival collected in the questionnaire and analyzed using descriptive statistics and frequency distribution tables and t-test. Results:Both groups of open and laparoscopic surgery had similar characteristics of age, sex, recurrence and disease-free survival, tumor margins and one-year mortality. The number of removed and involved lymph nodes was higher in the laparoscopic group (5.16 vs. 3.55, respectively, with P < 0.050, and 1.74 vs. 0.59 with P = 0.023), but the ratio of involved lymph nodes to the total number of removed lymph nodes was not different between the two groups (LNR) (P = 0.071). Tumor stage was higher in the laparoscopic group and most were in stages II and III (P < 0.001). Conclusions: Laparoscopic surgery is an effective technique for safe margin and removing lymph nodes in rectal cancer.

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“…As several randomized controlled trials (RCTs) have been published, the true assessment of the mortality and recurrence rate of LCS in CRC compared with open colorectal surgery (OCS) is best described in these reports [1,3,[11][12][13][14][15][16][17][18][19][20][21][22][23]. Therefore, a meta-analysis of RCTs seems appropriate to determine whether LCS leads to different mortality and recurrence rates when compared with OCS.…”

Section: Introductionmentioning

confidence: 99%

A meta-analysis of laparoscopy compared with open colorectal resection for colorectal cancer

Yang

Qin

et al. 2010

Med Oncol

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The aim of this study was to compare the outcome of the overall complication, mortality, and recurrence rate between laparoscopic resection and open surgery for colorectal cancer. We searched the Medline, Embase, and Cochrane Library and systematically reviewed the randomized controlled trials by comparing the overall complication, mortality, and recurrence rate between laparoscopic resection and open surgery for colorectal cancer. Fifteen trials with 4,207 patients who reported long-term outcomes of the overall complication, mortality, and recurrence rate were included. The combined results of the individual trials showed no statistically significant difference in the odds ratio (OR) for overall recurrence (OR 0.92, 95% CI, 0.77-1.11, P=0.34), local recurrence (OR 0.81, 95% CI, 0.59-1.12, P=0.20), distant metastasis (OR 1.01, 95% CI, 0.78-1.30, P=0.95), wound-site recurrence (OR 1.97, 95% CI, 0.77-5.02, P=0.16), colorectal cancer-related mortality (OR 0.82, 95% CI, 0.66-1.02, P=0.07), colon cancer-related mortality (OR 0.85, 95% CI, 0.66-1.09, P=0.20), rectal cancer-related mortality (OR 0.76, 95% CI, 0.53-1.11, P=0.16), and overall mortality (OR 0.87, 95% CI, 0.73-1.73, P=0.11) between the laparoscopic surgery and open surgery groups. The overall complications in the laparoscopic surgery group were much lower than that in the open surgery group (OR 0.71, 95% CI, 0.58-0.87, P=0.001). This meta-analysis showed that the successful laparoscopic colorectal resection for colorectal cancer was as effective as open surgery in terms of the oncological outcomes, thereby suggesting that laparoscopic surgery can be continued in patients with colorectal cancer.

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Long-Term Outcomes for Laparoscopic Versus Open Resection of Nonmetastatic Colorectal Cancer

Abstract: Long-term survival data support LS as a safe, effective alternative to conventional surgery for treating potentially curative colorectal cancer. However, the higher cumulative recurrence associated with LS in the colonic cancer group needs further research into its underlying cause.

Cited by 18 publications

References 25 publications

A Meta-analysis of the Short- and Long-Term Results of Randomized Controlled Trials That Compared Laparoscopy-Assisted and Conventional Open Surgery for Rectal Cancer

A Meta-analysis of the Short- and Long-Term Results of Randomized Controlled Trials That Compared Laparoscopy-Assisted and Conventional Open Surgery for Rectal Cancer

Comparison of Oncologic Short Term Results of Laparoscopic Versus Open Surgery of Rectal Cancer

A meta-analysis of laparoscopy compared with open colorectal resection for colorectal cancer

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