Long-term outcomes of preterm infants in the first 6 years of life: a nationwide population-based study in Korea

Jin, Ju Hyun; Lee, Sung Hee; Youk, Tae Mi; Yoon, Shin Won

doi:10.1007/s00431-022-04728-w

Cited by 8 publications

(3 citation statements)

References 39 publications

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“…These results seem to contradict the well-known fact that prematurity is a risk factor for CP [1,4]. A recent study based on the Korean population showed that a shorter the gestational age was associated with a higher risk for both CP and epilepsy [18]. The discordant results between population-based studies and our study or studies using CP registries could be explained by different study designs.…”

Section: Risk Factors For Epilepsy In Cerebral Palsycontrasting

confidence: 99%

Characteristics of Epilepsy in Children with Cerebral Palsy: A Single Tertiary Center Study

Yeo,

Han,

Kim

2023

Ann Child Neurol

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Purpose: The aim of this study was to describe the characteristics of epilepsy in cerebral palsy (CP) patients and identify risk factors for epilepsy and drug-resistant epilepsy.Methods: CP patients aged 18 years old or younger who visited the pediatric neurology department and/or rehabilitation department of a tertiary care hospital between January 2016 and December 2022 with a minimum follow-up period of 2 years were included. Demographic and clinical data, seizure characteristics, brain imaging, electroencephalography, and genetic evaluation results were reviewed retrospectively.Results: Among 268 patients included in this study, 36.9% had epilepsy and 10.8% had drug-resistant epilepsy. Asphyxia (29.3%), hemorrhage, infarction, and brain infection (25.3%) were associated with epilepsy. Epileptic CP patients were more likely to experience neonatal seizures (18.2% vs. 4.1%, <i>P</i><0.001) and febrile seizures (12.1% vs. 7.1%, <i>P</i>=0.02) than non-epilepsy CP patients. The most common cerebral subtype in patients with epilepsy was spastic quadriplegia (59.6%). Epilepsy patients were more severely impaired in gross motor function, with worse intellectual disability. Patients with macrocephaly or cerebral malformation were more likely to have drug resistance. Valproate (51.7% and 25.7%) and levetiracetam (41.4% and 25.7%) were the two most commonly used antiseizure medications, both in monotherapy and polytherapy.Conclusion: A history of asphyxia, febrile seizure, neonatal seizure, spastic quadriplegia, more severely impaired gross motor function, and intellectual disability were found to be risk factors for epilepsy. Further research with prospective data collection to develop a model for predicting seizures or epilepsy in CP patients is needed.

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Section: Risk Factors For Epilepsy In Cerebral Palsycontrasting

confidence: 99%

Characteristics of Epilepsy in Children with Cerebral Palsy: A Single Tertiary Center Study

Yeo,

Han,

Kim

2023

Ann Child Neurol

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“…In this study, we determined that the reason we found epilepsy and developmental delay more frequently was (20). We discovered that having CP and epilepsy was associated with an abnormal DDST-II test, but we couldn't find any link between decreasing gestational age, epilepsy, and CP.…”

Section: Discussionmentioning

confidence: 80%

Neurodevelopmental Outcomes in Preterm Infants

Ekici,

Yurdagül,

Aghazada

et al. 2024

esmj

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ÖZET Giriş: Yenidoğan yoğun bakım ünitelerinin (YYBÜ) artan teknolojik donanımı, deneyimli yoğun bakım ekibi ve destekleyici tedavilerin (antenatal kortikosteroid, sürfaktan) kullanılması, prematüre bebeklerin hayatta kalma oranlarını ve dolayısıyla morbidite oranlarını artırdı. Prematüre bebeklerde (≤ 34 hafta) en sık görülen nörolojik problem olan serebral palsi (SP) ve epilepsi sıklığının değerlendirilmesi amaçlandı. Yöntem: Bu çalışmaya 2016-2020 yılları arasında 34 hafta ve altı doğan ve takip edilen 253 prematüre bebek dahil edildi. Hastaların gebelik yaşı, doğum kilosu, mekanik ventilasyonu, nöbet durumu, YYBÜ’de kalış süresi, nörolojik muayeneleri ve Denver gelişimsel tarama testi (DGTT- II) incelendi. Bulgular: Ortalama gebelik yaşı 29,44 (24-34) hafta, doğum ağırlığı ise 1225 (990-1607) gramdı. YYBÜ’de kaldığı süre boyunca 26 hastada (%10,3) nöbet görüldü. Nöbetler en sık 28-31 haftalık prematürelerde görüldü (%57,7; p=0,02). Elli beş (%21,7) hastada anormal DDSTII vardı. Yenidoğan dönemindeki nöbetler ve içselleştirme süresi ile anormal DGTT- II arasında anlamlı fark vardı (sırasıyla p<0,001, p<0,05). Hastaların 46’sında (%15,8) nörogelişimsel gecikme, dokuzunda (%3,6) SP vardı (beşinde hemiparetik SP, ikisinde spastik parapleji ve ikisinde spastik tetraparezi vardı). On altı (%6,3) hastada epilepsi vardı; 9’unda (%3,6) konuşma bozukluğu vardı; 3’ünde (%1,2) hidrosefali vardı; 1’inde (%0,4) mikrosefali vardı; ve 1’inde (%0,4) makrosefali vardı. Yenidoğan nöbeti geçiren hastalarda epilepsi daha sık görüldü (p<0,001). Sonuç: Sürekli gelişimsel izleme ve değerlendirme, erken doğmuş bebeklerde gelişimsel gecikmelerin erken tespitine olanak sağlar. Erken tanı ve rehabilitasyon programlarına yönlendirme sekel düzeyini azaltabilir. En sık nörogelişimsel gecikme, SP, epilepsi ve konuşma bozukluğuyla karşılaştık. Anahtar Kelimeler: serebral palsi, DGTT- II, epilepsi, erken doğmuş bebekler

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“…Preventing preterm birth and low birth weight could be a fundamental intervention to improve the health outcomes of children born to cancer survivors. We also assessed the risk of epilepsy, language disorder, and hearing impairment, which are known to be increased in children born preterm 22 ; however, these diseases did not show a significant increase among children of female cancer survivors. We followed the children for approximately 6 years, but a longer follow-up study would be able to evaluate other diseases whose prevalence rate increase with age.…”

Section: Discussionmentioning

confidence: 99%

Perinatal and childhood outcomes of children born to female cancer survivors in South Korea

Jin,

Youk,

Yun

et al. 2024

Sci Rep

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Despite the increasing number of female cancer survivors, uncertainty remains regarding potential adverse health outcomes for their offspring. Comprehensive population-based studies would be invaluable for female cancer survivors in making decisions about their future. This study uses the National Health Information Database to investigate perinatal and long-term outcomes of offspring born to mothers with a history of cancer. In a South Korean cohort of 95,264 women aged 15–40 diagnosed with cancer between 2007 and 2010, we evaluated the outcomes of 15,221 children born to 11,092, cancer survivors. We selected 147,727 women without a history of cancer and 201,444 children as a control group. Our study found that children of female cancer survivors have a significantly higher odds ratio of primary outcomes including preterm birth, low birth weight, neonatal intensive care unit admission, and death. While there was no difference in the rate of death within 1 year of birth between the two groups, the total death rate during the follow-up period was significantly higher in children born to mothers with cancer. After adjusting for gestational age and birth weight, there was no statistically significant increased hazard ratio of secondary outcomes including cancer, chromosomal abnormalities, cerebral palsy, delayed development, epilepsy, language disorder, or hearing impairment.

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Long-term outcomes of preterm infants in the first 6 years of life: a nationwide population-based study in Korea

Cited by 8 publications

References 39 publications

Characteristics of Epilepsy in Children with Cerebral Palsy: A Single Tertiary Center Study

Characteristics of Epilepsy in Children with Cerebral Palsy: A Single Tertiary Center Study

Neurodevelopmental Outcomes in Preterm Infants

Perinatal and childhood outcomes of children born to female cancer survivors in South Korea

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